Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Joshua D. McManus"'
Autor:
Tanya Armstrong, Thomas W. von Geldern, Sen Z. Wang, Bradley Berven, Michael J. Abbott, Ivan Scandale, Susan A. Charman, Jason H. Chaplin, Andrea Khong, Joshua D. McManus, Eric Chatelain, Adriana Botero, Wayne M. Best, Julia Morizzi, Maria Kerfoot, Tien Nguyen, Paul W. Alexander, Karen L. White, R.C. Andrew Thompson, Martine Keenan, Eileen Ryan
Publikováno v:
Journal of Medicinal Chemistry. 55:4189-4204
We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma cruzi ( T. cruzi ), the causative agent of Chagas disease, and the results of structure-activity investigations leading to potent analogues with low nM IC(50)s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a30d423509261689188e5175fe646b
https://doi.org/10.1021/jm2015809
https://doi.org/10.1021/jm2015809
Autor:
Robin G. F. Giles, Joshua D. McManus
Publikováno v:
Tetrahedron Letters. 50:6361-6363
The rearrangement of (2′S,4′R,5′S)-2-(2′,5′-dimethyl-1′,3′-dioxolan-4′-yl)-4,5,7-trimethoxynaphthalen-1-yl 4″-methylbenzenesulfonate with titanium(IV) chloride affords (1R,3S,4R)-10-chloro-6,7,9-trimethoxy-1,3-dimethyl-3,4-dihydro-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00342395493e104105ce20631daaa8ea
https://doi.org/10.1016/j.tetlet.2009.08.107
https://doi.org/10.1016/j.tetlet.2009.08.107