Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Joshua D. Gregorio"'
Autor:
Hai Li, Andrew Luo, Steven J. Chapin, Shelley Erin Ackerman, Marcin Kowanetz, Michael N. Alonso, Po Y. Ho, Arthur Lee, Karla Henning, Samuel C. Kimmey, Benjamin Ackerman, Joshua D. Gregorio, Brian Safina, Vishnu C. Ramani, David Dornan, Lauren Y. Sheu, Jennifer Melrose, Cecelia Pearson, Richard P. Laura, Bruce H. Devens, Justin A. Kenkel, Edgar G. Engleman, Lisa Blum, David Y. Jackson, Heidi N. Leblanc, Joseph C. Gonzalez, Grant Yonehiro, Yaron Carmi, Felix J. Hartmann, Sean C. Bendall, Murray L. Nguyen, Angela Luo, Jason C. Paik
Publikováno v:
Nat Cancer
Innate pattern recognition receptor agonists, including Toll-like receptors (TLRs), alter the tumor microenvironment and prime adaptive antitumor immunity. However, TLR agonists present toxicities associated with widespread immune activation after sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436acc59b100dcb9f23295f5a324b4fb
https://europepmc.org/articles/PMC9012298/
https://europepmc.org/articles/PMC9012298/
Autor:
Po Ho, Matthew Zhou, Lisa Blum, Justin A. Kenkel, Joshua D. Gregorio, Cecelia Pearson, Shelley Erin Ackerman, Richard P. Laura, Andrew Luo, Angela Luo, Marcin Kowanetz, Brian Safina, Michael N. Alonso, David Dornan, Heidi LeBlanc
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Immune-stimulating antibody conjugates (ISACs) covalently attach immune stimulants to tumor-targeting antibodies such as trastuzumab. We have shown that HER2-targeted TLR7/8 ISACs elicit robust myeloid activation and tumor eradication in a