Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joshua D. Deschamps"'
A handheld platform for target protein detection and quantification using disposable nanopore strips
Autor:
Trevor J. Morin, William L. McKenna, Tyler D. Shropshire, Dustin A. Wride, Joshua D. Deschamps, Xu Liu, Reto Stamm, Hongyun Wang, William B. Dunbar
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Accessible point-of-care technologies that can provide immunoassay and molecular modalities could dramatically enhance diagnostics, particularly for infectious disease control in low-resource settings. Solid-state nanopores are simple and du
Externí odkaz:
https://doaj.org/article/d4eef1c81879446f87836983db6d0976
Autor:
Theodore R. Holman, Chakrapani Kalyanaraman, Jennyfer Tena, Matthew P. Jacobson, Gabriella Alvarez, Wan-Chen Tsai, Ansari Mukhtar Aleem, Joshua D. Deschamps
Publikováno v:
Biochemistry
Biochemistry, vol 58, iss 6
Biochemistry, vol 58, iss 6
Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f546fac581c1f96f8ac1a03aa67ffd
https://europepmc.org/articles/PMC7270147/
https://europepmc.org/articles/PMC7270147/
A handheld platform for target protein detection and quantification using disposable nanopore strips
Autor:
Stamm Reto, Joshua D. Deschamps, Trevor J. Morin, Xu Liu, William B. Dunbar, Tyler Shropshire, Mckenna William, Hongyun Wang, Dustin A. Wride
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Accessible point-of-care technologies that can provide immunoassay and molecular modalities could dramatically enhance diagnostics, particularly for infectious disease control in low-resource settings. Solid-state nanopores are simple and durable sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9632bdccc87ad50f1ffb4990bbcbbb05
http://europepmc.org/articles/PMC6172217
http://europepmc.org/articles/PMC6172217
Autor:
Jennifer M. Bomberger, Becca A. Flitter, Adam Yasgar, Joshua D. Deschamps, Anton Simeonov, J. Brian Jameson, David J. Maloney, Theodore R. Holman, Cody J. Freedman, Ajit Jadhav, Jeffrey A. Melvin, Abiola F. Ogunsola, Jason V. M. H. Nguyen
Publikováno v:
Biochemistry, vol 55, iss 23
Biochemistry
Biochemistry
Pseudomonas aeruginosa is an opportunistic pathogen that can cause nosocomial and chronic infections in immunocompromised patients. P. aeruginosa secretes a lipoxygenase, LoxA, but the biological role of this enzyme is currently unknown. LoxA is poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fce8bc937cebf7f2eda3ee8c95afb04
https://escholarship.org/uc/item/4kz0h0rg
https://escholarship.org/uc/item/4kz0h0rg
Publikováno v:
Biochemistry. 47:7364-7375
Human lipoxygenases (hLO) are a family of structurally related enzymes that catalyze the hydroperoxidation of polyunsaturated fatty acids using molecular oxygen (Scheme 1) (1). There are three main isozymes of pharmacological interest: 5-hLO, 12-hLO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b5dd3b1c6668579284c58ecd638dce
https://doi.org/10.1021/bi800550n
https://doi.org/10.1021/bi800550n
Autor:
Joshua D. Deschamps, Barbara N. Timmermann, Maria-Teresa Gutierrez-Lugo, Theodore R. Holman, Enrique Suarez
Publikováno v:
Planta Medica. 70:263-265
Chemical investigation of the aerial parts of Anadenanthera colubrina led to the isolation of a new flavonoid named anadanthoflavone ( 1), along with 11 known compounds: alnusenol, lupenone, lupeol, betulinic acid, alpha-amyrin, beta-amyrin, beta-sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca568bacd1d3ef515115fc9ce61a6518
https://doi.org/10.1055/s-2004-818920
https://doi.org/10.1055/s-2004-818920
Autor:
Joshua D. Deschamps, Wilfred A. van der Donk, Aaron T. Wecksler, Natalie K. Garcia, Theodore R. Holman, Victor Kenyon
Publikováno v:
Biochemistry. 48(36)
Allosteric regulation of human lipoxygenase (hLO) activity has recently been implicated in the cellular biology of prostate cancer. In the current work, we present isotope effect, pH, and substrate inhibitor data of epithelial 15-hLO-2, which probe t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82152aa0afaafab199aef0cc5f1376e
https://pubmed.ncbi.nlm.nih.gov/19645454
https://pubmed.ncbi.nlm.nih.gov/19645454
Autor:
Theodore R. Holman, Joshua D. Deschamps, Stephanie Whitman, Jeffrey T. Gautschi, Phillip Crews, Tyler A. Johnson, Nadine C. Gassner
Human lipoxygenases (hLO) have been implicated in a variety of diseases and cancers and each hLO isozyme appears to have distinct roles in cellular biology. This fact emphasizes the need for discovering selective hLO inhibitors for both understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1968d946091eaf4485081907467fd947
https://europepmc.org/articles/PMC2203963/
https://europepmc.org/articles/PMC2203963/
Publikováno v:
Bioorganicmedicinal chemistry. 14(12)
Lipoxygenases (LO) have been implicated in asthma, immune disorders, and various cancers and as a consequence, there is great interest in isolating selective LO isozyme inhibitors. Currently, there is much use of baicalein as a selective human platel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da910f6c153383cbcf28104836394e41
https://pubmed.ncbi.nlm.nih.gov/16500106
https://pubmed.ncbi.nlm.nih.gov/16500106
Autor:
Jocelyn R. Flanary, Xiaolin Cao, Victor Kenyon, Peter Rygaard Lassen, Robert H. Cichewicz, Theodore R. Holman, Phillip Crews, Laura J. Clifford, Teresa B. Freedman, Joshua D. Deschamps, Laurence A. Nafie
Publikováno v:
Bioorganicmedicinal chemistry. 13(19)
Electrospray ionization mass spectrometry-guided isolation of extracts from Didiscus aceratus led to the discovery of several new derivatives of the bioactive bisabolene-type sponge metabolite (S)-(+)-curcuphenol (1). The compounds obtained by this m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e5829973e2f3ccdf326ca110c8e9c4
https://pubmed.ncbi.nlm.nih.gov/16039133
https://pubmed.ncbi.nlm.nih.gov/16039133