Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Joshua D. Bernstock"'
Autor:
Jian Li, Shengxin Jia, Dengfeng Li, Lung Chow, Qiang Zhang, Yiyuan Yang, Xiao Bai, Qingao Qu, Yuyu Gao, Zhiyuan Li, Zongze Li, Rui Shi, Binbin Zhang, Ya Huang, Xinyu Pan, Yue Hu, Zhan Gao, Jingkun Zhou, WooYoung Park, Xingcan Huang, Hongwei Chu, Zhenlin Chen, Hu Li, Pengcheng Wu, Guangyao Zhao, Kuanming Yao, Muhamed Hadzipasic, Joshua D. Bernstock, Ganesh M. Shankar, Kewang Nan, Xinge Yu, Giovanni Traverso
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Dynamic tracking of spinal instrumentation could facilitate real-time evaluation of hardware integrity and in so doing alert patients/clinicians of potential failure(s). Critically, no method yet exists to continually monitor the integrity o
Externí odkaz:
https://doaj.org/article/26c38ccb1a0549659df0d255e707733d
Autor:
Yasir Durrani, Jakob V. E. Gerstl, Danielle Murphy, Ashley Harris, Imane Saali, Toby Gropen, Shashank Shekhar, Ari D. Kappel, Nirav J. Patel, Rose Du, Rodolfo E. Alcedo Guardia, Juan C. Vicenty‐Padilla, Adam A. Dmytriw, Vitor Mendes Pereira, Saef Izzy, Allauddin Khan, Mohammed A. Aziz‐Sultan, David S. Liebeskind, Jason M. Davies, Adnan H. Siddiqui, Edoardo Gaude, Joshua D. Bernstock
Publikováno v:
Stroke: Vascular and Interventional Neurology, Vol 4, Iss 4 (2024)
Background Large‐vessel occlusion (LVO) ischemic stroke is responsible for significant morbidity and mortality. We have previously described a novel tool for acute LVO detection that combines blood‐based biomarkers (glial fibrillary acidic protei
Externí odkaz:
https://doaj.org/article/ed933c25860f4c98b046fd01360e10dc
Autor:
Joshua D. Bernstock, Paramesh V. Karandikar, Jason A. Chen, Jakob Seidlitz, Gregory K. Friedman, David M. Meredith, Kevin X. Liu, Daphne Haas-Kogan, David A. Reardon, Pier Paolo Peruzzi
Publikováno v:
Frontiers in Surgery, Vol 11 (2024)
Intrinsic, expansile pontine tumors typically occur in the pediatric population. These tumors characteristically present as diffuse intrinsic pontine glioma (DIPG), which is now considered as diffuse midline glioma (DMG), H3K27-mutated of the pons. D
Externí odkaz:
https://doaj.org/article/79300f13b94a4f41a858aa026805f109
Autor:
Christopher Chang, Velina S. Chavarro, Jakob V. E. Gerstl, Sarah E. Blitz, Lennard Spanehl, Daniel Dubinski, Pablo A. Valdes, Lily N. Tran, Saksham Gupta, Luisa Esposito, Debora Mazzetti, Florian A. Gessler, Omar Arnaout, Timothy R. Smith, Gregory K. Friedman, Pierpaolo Peruzzi, Joshua D. Bernstock
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6733 (2024)
Glioblastoma is the most common and lethal central nervous system malignancy with a median survival after progression of only 6–9 months. Major biochemical mechanisms implicated in glioblastoma recurrence include aberrant molecular pathways, a recu
Externí odkaz:
https://doaj.org/article/e0a140c945b448e5aa9825558a68042e
Autor:
Hadi Abou-El-Hassan, Joshua D. Bernstock, Joshua I. Chalif, Taha Yahya, Rafael M. Rezende, Howard L. Weiner, Saef Izzy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The neuroimmunology of traumatic brain injury (TBI) has recently gained recognition as a crucial element in the secondary pathophysiological consequences that occur following neurotrauma. Both immune cells residing within the central nervous system (
Externí odkaz:
https://doaj.org/article/2ea49716601344ab965324de08bf8528
Autor:
Joshua D. Bernstock, Joshua I. Chalif, Rohan Jha, Ashley Brown, Walid I. Essayed, Arthur Caplan, Pierpaolo Peruzzi
Publikováno v:
Frontiers in Transplantation, Vol 2 (2023)
Under what circumstances, is it ethical to perform tumor surgery on a brain-dead individual? The neurosurgeons at Brigham and Women's Hospital were recently faced with such a question when asked to operate on a 28-year-old man who was pronounced brai
Externí odkaz:
https://doaj.org/article/9ddf811494f744c9b203708e566fe88b
Autor:
Jakob Seidlitz, Travis T. Mallard, Jacob W. Vogel, Younga H. Lee, Varun Warrier, Gareth Ball, Oskar Hansson, Leanna M. Hernandez, Ayan S. Mandal, Konrad Wagstyl, Michael V. Lombardo, Eric Courchesne, Joseph T. Glessner, Theodore D. Satterthwaite, Richard A.I. Bethlehem, Joshua D. Bernstock, Shinya Tasaki, Bernard Ng, Chris Gaiteri, Jordan W. Smoller, Tian Ge, Raquel E. Gur, Michael J. Gandal, Aaron F. Alexander-Bloch
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113439- (2023)
Summary: Human brain size changes dynamically through early development, peaks in adolescence, and varies up to 2-fold among adults. However, the molecular genetic underpinnings of interindividual variation in brain size remain unknown. Here, we leve
Externí odkaz:
https://doaj.org/article/64ee1401f7fc44968f6a52b884af8318
Autor:
Zhuoran Wang, Qiang Li, Brad J. Kolls, Brian Mace, Shu Yu, Xuan Li, Wei Liu, Eduardo Chaparro, Yuntian Shen, Lihong Dang, Ángela del Águila, Joshua D. Bernstock, Kory R. Johnson, Junjie Yao, William C. Wetsel, Scott D. Moore, Dennis A. Turner, Wei Yang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
XBP1s is a key effector of the unfolded protein response. Neuron-specific overexpression of Xbp1s in the brain leads to impaired GABAergic signaling and recurrent spontaneous seizures in mice.
Externí odkaz:
https://doaj.org/article/41145015ec054931bd78b62feab0a1cb
Autor:
Ari D. Kappel, Rohan Jha, Saibaba Guggilapu, William J. Smith, Abdullah H. Feroze, Adam A. Dmytriw, Juan Vicenty-Padilla, Rodolfo E. Alcedo Guardia, Florian A. Gessler, Nirav J. Patel, Rose Du, Alfred P. See, Pier Paolo Peruzzi, Mohammad A. Aziz-Sultan, Joshua D. Bernstock
Publikováno v:
Cancers, Vol 16, Iss 8, p 1594 (2024)
High-grade gliomas (HGGs) have a poor prognosis and are difficult to treat. This review examines the evolving landscape of endovascular therapies for HGGs. Recent advances in endovascular catheter technology and delivery methods allow for super-selec
Externí odkaz:
https://doaj.org/article/32dcbf63d5e94c4db7f6d9cc7544e16f
Autor:
Paramesh V. Karandikar, Lyle Suh, Jakob V. E. Gerstl, Sarah E. Blitz, Qing Rui Qu, Sae-Yeon Won, Florian A. Gessler, Omar Arnaout, Timothy R. Smith, Pier Paolo Peruzzi, Wei Yang, Gregory K. Friedman, Joshua D. Bernstock
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Oncolytic viral (OV) therapies are promising novel treatment modalities for cancers refractory to conventional treatment, such as glioblastoma, within the central nervous system (CNS). Although OVs have received regulatory approval for use in the CNS
Externí odkaz:
https://doaj.org/article/93e5eb42bcf84400ba4a33156b733708