Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joshua D Kidd"'
Autor:
Fernando G Vieira, Valerie R Tassinari, Joshua D Kidd, Andrew Moreno, Kenneth Thompson, Steven Perrin, Alan Gill, Theo Hatzipetros
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0292190 (2024)
Amyotrophic lateral sclerosis (ALS) has been linked to overactivity of the protein kinase RNA-like ER kinase (PERK) branch of the unfolded protein response (UPR) pathway, both in ALS patients and mouse models. However, attempts to pharmacologically m
Externí odkaz:
https://doaj.org/article/3f43e16213ce47a18658414260f2a41c
Autor:
Fernando G Vieira, Qinggong Ping, Andy J Moreno, Joshua D Kidd, Kenneth Thompson, Bingbing Jiang, John M Lincecum, Monica Z Wang, Gerard S De Zutter, Valerie R Tassinari, Beth Levine, Theo Hatzipetros, Alan Gill, Steven Perrin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135570 (2015)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons. The mechanisms leading to motor neuron degeneration in ALS are unclear. However, there is evidence for involvement of endoplasmic r
Externí odkaz:
https://doaj.org/article/f052d1fb3a364d89b9b51dacb83c5f26
Autor:
Fernando G Vieira, Eva LaDow, Andy Moreno, Joshua D Kidd, Beth Levine, Kenneth Thompson, Alan Gill, Steven Finkbeiner, Steven Perrin
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e91608 (2014)
Treatment options for people living with amyotrophic lateral sclerosis (ALS) are limited and ineffective. Recently, dexpramipexole (RPPX) was advanced into human ALS clinical trials. In the current studies, we investigated RPPX in two parallel screen
Externí odkaz:
https://doaj.org/article/b2f5a8bfa5d94825bb4e8c5d5954e8a7
Autor:
Alan Gill, Fernando G. Vieira, Beth Levine, Kenneth Thompson, Theo Hatzipetros, Valerie R. Tassinari, Joshua D. Kidd, Andy J. Moreno, Steven Perrin
Publikováno v:
IBRO Reports
IBRO Reports, Vol 2, Iss C, Pp 47-53 (2017)
IBRO Reports, Vol 2, Iss C, Pp 47-53 (2017)
A copper chelator known as diacetylbis(N(4)-methylthiosemicarbazonato) copper II (CuATSM), has been reported to be efficacious in multiple transgenic SOD1 models of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder affecting mot
Autor:
Cindy Gill, Theo Hatzipetros, Beth Levine, Valerie R. Tassinari, Monica Z. Wang, Joshua D. Kidd, Marcel Maier, Alan Gill, Fernando G. Vieira, Andrew Moreno, James P. Phelan, Jan Grimm, Kenneth Thompson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Non-natively folded variants of superoxide dismutase 1 (SOD1) are thought to contribute to the pathogenesis of familial amyotrophic lateral sclerosis (ALS), however the relative toxicities of these variants are controversial. Here, we aimed to deciph
Autor:
Melissa Osborne, Andrew Austin, Cathleen M. Lutz, Joshua D. Kidd, Andy J. Moreno, Crystal Davis, Valerie R. Tassinari, Theo Hatzipetros, Laurent P. Bogdanik, Fernando G. Vieira, Steve Perrin
Publikováno v:
Brain Research. 1584:59-72
ALS therapy development has been hindered by the lack of rodent animal models. The discovery of TDP-43, a transcription factor that accumulates in the cytoplasm of motor neurons (MNs) in most cases of ALS, prompted attempts to develop TDP-43-based mo
Publikováno v:
The Journal of Gemmology. 34:334-343
A fundamental task for gemmologists is determining whether an emerald is natural or synthetic. Within the laser-excited photoluminescence spectrum of emerald, the peak positions and relative intensities of two emissions in the 680–685 nm range, kno
Autor:
Andy J. Moreno, Kenneth Thompson, Alan Gill, Fernando G. Vieira, Joshua D. Kidd, Theo Hatzipetros
Publikováno v:
Journal of Visualized Experiments.
The SOD1-G93A transgenic mouse is the most widely used animal model of amyotrophic lateral sclerosis (ALS). At ALS TDI we developed a phenotypic screening protocol, demonstrated in video herein, which reliably assesses the neuromuscular function of S
Autor:
Alan Gill, Steven Perrin, Fernando G. Vieira, Kenneth Thompson, Andy J. Moreno, Steven Finkbeiner, Beth Levine, Joshua D. Kidd, Eva S. LaDow
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e91608 (2014)
PLoS ONE
Finkbeiner, Steven; Vieira, FG; LaDow, E; Moreno, A; Kidd, JD; Levine, B; et al.(2014). Dexpramipexole is ineffective in two models of ALS related neurodegeneration. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8dh6j77j
PLoS ONE
Finkbeiner, Steven; Vieira, FG; LaDow, E; Moreno, A; Kidd, JD; Levine, B; et al.(2014). Dexpramipexole is ineffective in two models of ALS related neurodegeneration. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8dh6j77j
Treatment options for people living with amyotrophic lateral sclerosis (ALS) are limited and ineffective. Recently, dexpramipexole (RPPX) was advanced into human ALS clinical trials. In the current studies, we investigated RPPX in two parallel screen
Autor:
Ricardo Sanchez, John M. Lincecum, Isarelis J Carrion, Joshua D. Kidd, Beth Levine, Andrew Moreno, Gerald S De Zutter, Kenneth Thompson, Alan Gill, Shawn M Sullivan, Fernando G. Vieira, Monica Z. Wang, Bashar M. Al‐Nakhala, Steven Perrin
Publikováno v:
Nature genetics. 42(5)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motor neurons. Using unbiased transcript profiling in an ALS mouse model, we identified a role for the co-stimulatory pathway, a key regulat