Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joshua D Eaton"'
Publikováno v:
eLife, Vol 13 (2024)
RNA polymerase II (RNAPII) transcription initiates bidirectionally at many human protein-coding genes. Sense transcription usually dominates and leads to messenger RNA production, whereas antisense transcription rapidly terminates. The basis for this
Externí odkaz:
https://doaj.org/article/2c3f24c7b7a5449b86eaae485b5c2a3b
Autor:
Benjamin H. Jenkins, Finlay Maguire, Guy Leonard, Joshua D. Eaton, Steven West, Benjamin E. Housden, David S. Milner, Thomas A. Richards
Publikováno v:
Royal Society Open Science, Vol 8, Iss 4 (2021)
Endosymbiosis was fundamental for the evolution of eukaryotic complexity. Endosymbiotic interactions can be dissected through forward- and reverse-genetic experiments, such as RNA-interference (RNAi). However, distinguishing small (s)RNA pathways in
Externí odkaz:
https://doaj.org/article/5797075f445f481589d370f2df1e2706
Autor:
Lee Davidson, Laura Francis, Ross A. Cordiner, Joshua D. Eaton, Chris Estell, Sara Macias, Javier F. Cáceres, Steven West
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2779-2791.e5 (2019)
Summary: Cell-based studies of human ribonucleases traditionally rely on methods that deplete proteins slowly. We engineered cells in which the 3′→5′ exoribonucleases of the exosome complex, DIS3 and EXOSC10, can be rapidly eliminated to assess
Externí odkaz:
https://doaj.org/article/d371ae4c1a99434ea1385794f47c8f8f
Autor:
Joshua D. Eaton, Steven West
Publikováno v:
Trends in Genetics. 36:664-675
RNA polymerase II (Pol II) transcribes hundreds of thousands of transcription units - a reaction always brought to a close by its termination. Because Pol II transcribes multiple gene types, its termination occurs in a variety of ways, with the polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a7b55157adeb994e0861d958c95b3d
https://doi.org/10.1016/j.tig.2020.05.008
https://doi.org/10.1016/j.tig.2020.05.008
Autor:
Steve West, Benjamin E. Housden, Guy Leonard, Finlay Maguire, Thomas A. Richards, Joshua D. Eaton, Benjamin H. Jenkins, S. Milner David
Eukaryote-eukaryote endosymbiosis was responsible for the spread of chloroplast (plastid) organelles. Stability is required for the metabolic and genetic integration that drives the establishment of new organelles, yet the mechanisms which act to sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2a7eaa922ca531118274bd78e12cf2c
https://doi.org/10.1101/2021.04.11.439338
https://doi.org/10.1101/2021.04.11.439338
Autor:
Steven West, David S. Milner, Thomas A. Richards, Benjamin H. Jenkins, Joshua D. Eaton, Guy Leonard, Benjamin E. Housden, Finlay Maguire
Publikováno v:
Royal Society Open Science, Vol 8, Iss 4 (2021)
Royal Society open science
Royal Society open science
Endosymbiosis was fundamental for the evolution of eukaryotic complexity. Endosymbiotic interactions can be dissected through forward- and reverse-genetic experiments, such as RNA-interference (RNAi). However, distinguishing small (s)RNA pathways in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca073cf975e837b79ae7481c4266dc2d
https://doi.org/10.1098/rsos.210140
https://doi.org/10.1098/rsos.210140
Autor:
Steven West, Benjamin H. Jenkins, Finlay Maguire, David S. Milner, Guy Leonard, Thomas A. Richards, Benjamin E. Housden, Joshua D. Eaton
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Stable endosymbiosis between eukaryotic microbes has driven the evolution of further cellular complexity. Yet the mechanisms that can act to stabilize an emergent eukaryote–eukaryote endosymbiosis are unclear. Using the model facultati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c2a642608dc00e2477774763af055e
Autor:
David S. Milner, Finlay Maguire, Steven West, Guy Leonard, Thomas A. Richards, Benjamin H. Jenkins, Benjamin E. Housden, Joshua D. Eaton
Endosymbiosis was fundamental for the evolution of eukaryotic complexity. Endosymbiotic interactions can be dissected through forward and reverse-genetic experiments, such as RNA-interference (RNAi). However, distinguishing small (s)RNA pathways in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2022e274ad103d373708c470493d3a
https://doi.org/10.1101/2020.12.16.423098
https://doi.org/10.1101/2020.12.16.423098
Publikováno v:
Cell Reports
Summary Many RNA polymerases terminate transcription using allosteric/intrinsic mechanisms, whereby protein alterations or nucleotide sequences promote their release from DNA. RNA polymerase II (Pol II) is somewhat different based on its behavior at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4814f6c3215defa4eb10a173dccc8be9
https://pubmed.ncbi.nlm.nih.gov/33113359
https://pubmed.ncbi.nlm.nih.gov/33113359
A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes
The allosteric and torpedo models have been used for 30 yr to explain how transcription terminates on protein-coding genes. The former invokes termination via conformational changes in the transcription complex and the latter proposes that degradatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fac8deace04b180cbf8aa77a3b5e56
https://europepmc.org/articles/PMC6938672/
https://europepmc.org/articles/PMC6938672/