An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection

Autor: Carly G. K. Ziegler, Anna H. Owings, Michelle Galeas-Pena, Samuel W. Kazer, Vincent N. Miao, Andrew W. Navia, Ying Tang, Joshua D. Bromley, Peter Lotfy, Meredith Sloan, Hannah Laird, Haley B. Williams, Micayla George, Riley S. Drake, Yilianys Pride, George E. Abraham, Michal Senitko, Tanya O. Robinson, Gill Diamond, Michail S. Lionakis, Alex K. Shalek, Jose Ordovas-Montanes, Bruce H. Horwitz, Sarah C. Glover

Publikováno v: Microbiology Spectrum, Vol 12, Iss 6 (2024)

ABSTRACT Recent case reports and epidemiological data suggest that fungal infections represent an underappreciated complication among people with severe COVID-19. However, the frequency of fungal colonization in patients with COVID-19 and association

Externí odkaz: https://doaj.org/article/a7e7a9fbe87a46db9ef1b7216c890566

Expanding the HDAC druggable landscape beyond enzymatic activity

Autor: Julien Olivet, Soon Gang Choi, Salvador Sierra, Tina M. O’Grady, Mario de la Fuente Revenga, Florent Laval, Vladimir V. Botchkarev, Christoph Gorgulla, Paul W. Coote, Jérémy Blavier, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song, Zoe C. Yeoh, Bin Hu, Anthony C. Varca, Jonathan Bruyr, Samira Ibrahim, Tasneem Jivanjee, Joshua D. Bromley, Sarah K. Nyquist, Aaron Richardson, Hong Yue, Yang Wang, Natalia Calonghi, Alessandra Stefan, Kerstin Spirohn, Didier Vertommen, Maria F. Baietti, Irma Lemmens, Hyuk-Soo Seo, Mikhail G. Dozmorov, Luc Willems, Jan Tavernier, Kalyan Das, Eleonora Leucci, Alejandro Hochkoeppler, Zhen-Yu Jim Sun, Michael A. Calderwood, Tong Hao, Alex K. Shalek, David E. Hill, Andras Boeszoermenyi, Haribabu Arthanari, Sara J. Buhrlage, Sirano Dhe-Paganon, Javier González-Maeso, Franck Dequiedt, Jean-Claude Twizere, Marc Vidal

Enzymatic pockets such as those of histone deacetylases (HDACs) are among the most favored targets for drug development. However, enzymatic inhibitors often exhibit low selectivity and high toxicity due to targeting multiple enzyme paralogs, which ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8635e9e2aa438eb8f00e273e12bf49c9
https://doi.org/10.1101/2022.12.07.519454

Enriching and Characterizing T-Cell Repertoires from 3' Barcoded Single-Cell Whole Transcriptome Amplification Products

Autor: Tasneem Jivanjee, Samira Ibrahim, Sarah K. Nyquist, G. James Gatter, Joshua D. Bromley, Swati Jaiswal, Bonnie Berger, Samuel M. Behar, J. Christopher Love, Alex K. Shalek

Publikováno v: Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071627112

Antigen-specific T cells play an essential role in immunoregulation and diseases such as cancer. Characterizing the T cell receptor (TCR) sequences that encode T cell specificity is critical for elucidating the antigenic determinants of immunological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35388076d2c9051ad2167e8112e35028
http://arxiv.org/abs/2203.11266

Meta-genomic detection of Candida spp. in the nasopharynx and upper airway of patients with severe COVID-19

Autor: Sarah C Glover, Vincent N Miao, Anna H Owings, Andrew W Navia, Ying Ting, Joshua D Bromley, Peter Lotfy, Meredith Sloan, Hannah Laird, Haley Williams, Micayla N George, Riley D Drake, Taylor Christian, Adam Parker, Campbell Sindel, Molly Burger, Mohammad Hasan, George Abraham, Michal Senitko, Alex N Shalek, Bruce Horwitz, Carly N Ziegler

Publikováno v: The Journal of Immunology. 208:114.11-114.11

Recent case reports and epidemiological data suggest fungal infections represent an under-appreciated respiratory co-infection among people with severe COVID-19, however the frequency and clinical impact is currently unknown. We have previously gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d75b35303b1b9c982fd1999af5c95ea
https://doi.org/10.4049/jimmunol.208.supp.114.11

Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis).

Autor: Jaiswal, Swati¹ (AUTHOR), Nyquist, Sarah K.^2,3,4,5,6,7 (AUTHOR), Boyce, Shayla¹ (AUTHOR), Jivanjee, Tasneem^2,3,4 (AUTHOR), Ibrahim, Samira^2,3,4 (AUTHOR), Bromley, Joshua D.^2,3,4,8 (AUTHOR), Gatter, G. James^2,3,4 (AUTHOR), Gideon, Hannah⁹ (AUTHOR), Patel, Kush⁹ (AUTHOR), Ganchua, Sharie Keanne⁹ (AUTHOR), Berger, Bonnie^5,6 (AUTHOR), Fortune, Sarah M.^10,11 (AUTHOR), Flynn, JoAnne L.⁹ (AUTHOR), Shalek, Alex K.^{2,3,4,10,11,12} (AUTHOR), Behar, Samuel M.¹ (AUTHOR) samuel.behar@umassmed.edu

Publikováno v: BMC Genomics. 9/12/2022, Vol. 23 Issue 1, p1-15. 15p.