Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joshua Crapser"'
Autor:
Hai Zhang, Lujia Chen, Kevin G. Johnston, Joshua Crapser, Kim N. Green, Nicole My-Linh Ha, Andrea J. Tenner, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu
Publikováno v:
Neurobiology of Disease, Vol 176, Iss , Pp 105939- (2023)
A key challenge in developing diagnosis and treatments for Alzheimer's disease (AD) is to detect abnormal network activity at as early a stage as possible. To date, behavioral and neurophysiological investigations in AD model mice have yet to conduct
Externí odkaz:
https://doaj.org/article/94f303bca8164062b3c45e8aa6ad71c0
Autor:
Lindsay A Hohsfield, Allison R Najafi, Yasamine Ghorbanian, Neelakshi Soni, Joshua Crapser, Dario X Figueroa Velez, Shan Jiang, Sarah E Royer, Sung Jin Kim, Caden M Henningfield, Aileen Anderson, Sunil P Gandhi, Ali Mortazavi, Matthew A Inlay, Kim N Green
Publikováno v:
eLife, Vol 10 (2021)
Microglia, the brain’s resident myeloid cells, play central roles in brain defense, homeostasis, and disease. Using a prolonged colony-stimulating factor 1 receptor inhibitor (CSF1Ri) approach, we report an unprecedented level of microglial depleti
Externí odkaz:
https://doaj.org/article/57a85a00af094a2eb7af5592fc186f1a
Autor:
Elizabeth Spangenberg, Paul L. Severson, Lindsay A. Hohsfield, Joshua Crapser, Jiazhong Zhang, Elizabeth A. Burton, Ying Zhang, Wayne Spevak, Jack Lin, Nicole Y. Phan, Gaston Habets, Andrey Rymar, Garson Tsang, Jason Walters, Marika Nespi, Parmveer Singh, Stephanie Broome, Prabha Ibrahim, Chao Zhang, Gideon Bollag, Brian L. West, Kim N. Green
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Genetics implicate microglia in Alzheimer’s disease pathogenesis, but their roles remain unclear. Here, the authors find that microglial depletion in a mouse model of Alzheimer’s disease impairs plaque formation and that Aβ-induced changes in ne
Externí odkaz:
https://doaj.org/article/ab83dec7482d44a28b96b168ea75f0ff
Autor:
Rodney M. Ritzel, Abdullah Al Mamun, Joshua Crapser, Rajkumar Verma, Anita R. Patel, Brittany E. Knight, Nia Harris, Nickolas Mancini, Meaghan Roy-O’Reilly, Bhanu Priya Ganesh, Fudong Liu, Louise D. McCullough
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-16 (2019)
Abstract Background Ischemic stroke results in a robust inflammatory response within the central nervous system. As the immune-inhibitory CD200-CD200 receptor 1 (CD200R1) signaling axis is a known regulator of immune homeostasis, we hypothesized that
Externí odkaz:
https://doaj.org/article/bd41130a382a4de5a03d5632a95c4100
Autor:
Hai, Zhang, Lujia, Chen, Kevin G, Johnston, Joshua, Crapser, Kim N, Green, Nicole My-Linh, Ha, Andrea J, Tenner, Todd C, Holmes, Douglas A, Nitz, Xiangmin, Xu
A key challenge in developing diagnosis and treatments for Alzheimer's disease (AD) is to detect abnormal network activity at as early a stage as possible. To date, behavioral and neurophysiological investigations in AD model mice have yet to conduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c742778d70ca1ad41f7a7612d1085e34
https://escholarship.org/uc/item/4xs9b7xc
https://escholarship.org/uc/item/4xs9b7xc
Autor:
Joshua Crapser, Anthony Patrizz, Anna Schrecengost, Julia Kofler, Yun-Ju Lai, Nickolas S. Mancini, Evan R. Jellison, Anita Patel, Rodney M. Ritzel, Fudong Liu, Diego Morales-Scheihing, Jeremy M. Grenier, Venugopal Reddy Venna, Rajkumar Verma, Louise D. McCullough
Publikováno v:
Acta Neuropathologica
The peripheral immune system plays a critical role in aging and in the response to brain injury. Emerging data suggest inflammatory responses are exacerbated in older animals following ischemic stroke; however, our understanding of these age-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dce14b13aacb9326dc0f9677d7c2784
https://doi.org/10.1007/s00401-018-1859-2
https://doi.org/10.1007/s00401-018-1859-2
Autor:
Venugopal Reddy Venna, Rodney M. Ritzel, Kendra Maas, Joshua Crapser, Anita Patel, Anjali Chauhan, Rajkumar Verma, Edward C. Koellhoffer, Joerg Graf, Fudong Liu, Austin Ricker, Louise D. McCullough
Publikováno v:
Scopus-Elsevier
Aging (Albany NY)
Aging (Albany NY)
Aging is an important risk factor for post-stroke infection, which accounts for a large proportion of stroke-associated mortality. Despite this, studies evaluating post-stroke infection rates in aged animal models are limited. In addition, few studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d48dd565ca7eda9784ffac80e8664c
https://doi.org/10.18632/aging.100952
https://doi.org/10.18632/aging.100952
Autor:
Joshua Crapser, Abdullah Al Mamun, B. Knight, Nickolas S. Mancini, Rodney M. Ritzel, Meaghan Roy-O'Reilly, Anita Patel, Rajkumar Verma, Fudong Liu, Louise D. McCullough, Nia M. Harris, Bhanu P. Ganesh
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-16 (2019)
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-16 (2019)
Background Ischemic stroke results in a robust inflammatory response within the central nervous system. As the immune-inhibitory CD200-CD200 receptor 1 (CD200R1) signaling axis is a known regulator of immune homeostasis, we hypothesized that it may p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e8944eda33ebcff23d8624af18292d
https://pubmed.ncbi.nlm.nih.gov/30777093
https://pubmed.ncbi.nlm.nih.gov/30777093
Autor:
Joshua Crapser, Fudong Liu, Louise D. McCullough, B. Knight, Rodney M. Ritzel, Abdullah Al Mamun, Nia M. Harris, Nickolas S. Mancini, Rajkumar Verma, Anita Patel
Publikováno v:
Stroke. 49
Introduction: In ischemic stroke, central nervous system homeostasis is dysregulated, leading to a significant inflammatory response, cell death, and impaired neuronal survival. The immune-inhibitory CD200-CD200 Receptor 1 signaling axis is a key reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f6607bace2659b6df879b333343203d
https://doi.org/10.1161/str.49.suppl_1.tmp35
https://doi.org/10.1161/str.49.suppl_1.tmp35
Publikováno v:
Transl Stroke Res
Sirtuins (Sirt) are a family of NAD+ dependent histone deacetylase (HDAC) proteins implicated in aging, cell cycle regulation, and metabolism. These proteins are involved in the epigenetic modification of neuromodulatory proteins after strokevia acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c92876e58386394512dec46e088cf19
https://pubmed.ncbi.nlm.nih.gov/29302794
https://pubmed.ncbi.nlm.nih.gov/29302794