Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joshua C. Rosen"'
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Kirsten rat sarcoma viral oncogene homolog mutations are observed in 25% of lung adenocarcinoma and 40% of these are G12C mutations. Historically, no approved targeted agents were available for patients with any KRAS mutation, and response rates to s
Externí odkaz:
https://doaj.org/article/a72cd08431844f868d2e8b1e1cddf4db
Autor:
Joshua C. Rosen, Jessica Weiss, Nhu-An Pham, Quan Li, Sebastiao N. Martins-Filho, Yuhui Wang, Ming-Sound Tsao, Nadeem Moghal
Publikováno v:
Translational Oncology, Vol 14, Iss 10, Pp 101179- (2021)
Gain-of-function Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations occur in 25% of lung adenocarcinomas, and these tumors are challenging to treat. Some preclinical work, largely based on cell lines, suggested KRASmut lung cancers are espec
Externí odkaz:
https://doaj.org/article/89a26fc9aa484300990da8508907c577
Autor:
Ming-Sound Tsao, Nadeem Moghal, Geoffrey Liu, Benjamin Haibe-Kains, Nhu-An Pham, Laura Tamblyn, Yu-Hui Wang, Ming Li, Joshua C. Rosen, Arvind Singh Mer, Quan Li, Vibha Raghavan, Sebastiao N. Martins-Filho, Michael Cabanero, Hirotsugu Notsuda, Ni Liu, Christine Ng, Nikolina Radulovich, Ruoshi Shi
Supplementary Data Table S1, 3-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad664809adbc53e2b5a1f2cb59afe6a8
https://doi.org/10.1158/1078-0432.22474499.v1
https://doi.org/10.1158/1078-0432.22474499.v1
Autor:
Ming-Sound Tsao, Nadeem Moghal, Geoffrey Liu, Benjamin Haibe-Kains, Nhu-An Pham, Laura Tamblyn, Yu-Hui Wang, Ming Li, Joshua C. Rosen, Arvind Singh Mer, Quan Li, Vibha Raghavan, Sebastiao N. Martins-Filho, Michael Cabanero, Hirotsugu Notsuda, Ni Liu, Christine Ng, Nikolina Radulovich, Ruoshi Shi
Purpose:Non–small cell lung cancer (NSCLC) is the most common cause of cancer-related deaths worldwide. There is an unmet need to develop novel clinically relevant models of NSCLC to accelerate identification of drug targets and our understanding o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048c8862d3e9f390a18a9389b4defa6f
https://doi.org/10.1158/1078-0432.c.6528803
https://doi.org/10.1158/1078-0432.c.6528803
Autor:
Ming-Sound Tsao, Nadeem Moghal, Geoffrey Liu, Benjamin Haibe-Kains, Nhu-An Pham, Laura Tamblyn, Yu-Hui Wang, Ming Li, Joshua C. Rosen, Arvind Singh Mer, Quan Li, Vibha Raghavan, Sebastiao N. Martins-Filho, Michael Cabanero, Hirotsugu Notsuda, Ni Liu, Christine Ng, Nikolina Radulovich, Ruoshi Shi
Supplementary Data Figure S1-5, Table S2, 5-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f872d0d89cfa35e487960741dd208633
https://doi.org/10.1158/1078-0432.22474502.v1
https://doi.org/10.1158/1078-0432.22474502.v1
Autor:
Sebastiao N. Martins-Filho, Nadeem Moghal, Nhu-An Pham, Joshua C. Rosen, Jessica Weiss, Yuhui Wang, Ming-Sound Tsao, Quan Li
Publikováno v:
Translational Oncology, Vol 14, Iss 10, Pp 101179-(2021)
Translational Oncology
Translational Oncology
Highlights • The XPO1 inhibitor Selinexor inhibits growth of KRASmut lung cancer PDXs. • Selinexor is effective in G12C and non-G12C KRASmut lung cancers. • Selinexor Is more effective than the MEK inhibitor trametinib in KRASmut lung cancers.
Autor:
Sebastiao N. Martins-Filho, Nadeem Moghal, Hirotsugu Notsuda, Nikolina Radulovich, Geoffrey Liu, Laura Tamblyn, Benjamin Haibe-Kains, Ming Li, Yuhui Wang, Michael Cabanero, Ruoshi Shi, Joshua C. Rosen, Christine Ng, Ming-Sound Tsao, Arvind Singh Mer, Vibha Raghavan, Nhu An Pham, Ni Liu, Quan Li
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(5)
Purpose: Non–small cell lung cancer (NSCLC) is the most common cause of cancer-related deaths worldwide. There is an unmet need to develop novel clinically relevant models of NSCLC to accelerate identification of drug targets and our understanding