Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Joshua C. Cyktor"'
Autor:
Dennis C. Copertino Jr., Carissa S. Holmberg, Jared Weiler, Adam R. Ward, J. Natalie Howard, Callie Levinger, Alina P.S. Pang, Michael J. Corley, Friederike Dündar, Paul Zumbo, Doron Betel, Rajesh T. Gandhi, Deborah K. McMahon, Ronald J. Bosch, Noemi Linden, Bernard J. Macatangay, Joshua C. Cyktor, Joseph J. Eron, John W. Mellors, Colin Kovacs, Erika Benko, Alberto Bosque, R. Brad Jones, for the AIDS Clinical Trials Group (ACTG) A5321 Team
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
IL-15 is under clinical investigation toward the goal of curing HIV infection because of its abilities to reverse HIV latency and enhance immune effector function. However, increased potency through combination with other agents may be needed. 3-Hydr
Externí odkaz:
https://doaj.org/article/ed18029fbf2043e591567763be3f9138
Autor:
Melissa A. Tosiano, Hanna Mar, Dianna Hoeth, Joseph J. Eron, Rajesh T. Gandhi, Deborah K. McMahon, Ronald J. Bosch, John W. Mellors, Joshua C. Cyktor
Publikováno v:
Journal of Virus Eradication, Vol 8, Iss 4, Pp 100095- (2022)
Background: The ability of automated, FDA-cleared plasma HIV-1 RNA assays to detect low-level viremia, compared to manual, highly sensitive research-only methods, is not well-defined. We therefore tested paired plasma samples from people with HIV-1 (
Externí odkaz:
https://doaj.org/article/8ab1738fb15a4690a699c45cc74ef7b0
Publikováno v:
Journal of Virus Eradication, Vol 8, Iss 2, Pp 100073- (2022)
Antiretroviral therapy (ART) for HIV-1 has dramatically improved outcomes for people living with HIV-1 but requires life-long adherence and can be associated with short and long-term toxicity. Numerous pre-clinical and clinical investigations are und
Externí odkaz:
https://doaj.org/article/dc8732fdc9a6406c97de2dd88c8e4ae0
Autor:
Geoffrey T. Ivison, Elena Vendrame, Giovanny J. Martínez-Colón, Thanmayi Ranganath, Rosemary Vergara, Nancy Q. Zhao, Maureen P. Martin, Sean C. Bendall, Mary Carrington, Joshua C. Cyktor, Deborah K. McMahon, Joseph Eron, R. Brad Jones, John W. Mellors, Ronald J. Bosch, Rajesh T. Gandhi, Susan Holmes, Catherine A. Blish, The ACTG 5321 Team
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
The latent HIV-1 reservoir represents a major barrier to achieving a long-term antiretroviral therapy (ART)-free remission or cure for HIV-1. Natural Killer (NK) cells are innate immune cells that play a critical role in controlling viral infections
Externí odkaz:
https://doaj.org/article/c25a0532cc3d486983f8f67d814dd06a
Autor:
Michael J. Bale, Mary Grace Katusiime, Daria Wells, Xiaolin Wu, Jonathan Spindler, Elias K. Halvas, Joshua C. Cyktor, Ann Wiegand, Wei Shao, Mark F. Cotton, Stephen H. Hughes, John W. Mellors, John M. Coffin, Gert U. Van Zyl, Mary F. Kearney
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
HIV-1 integrates its genome into the DNA of host cells. Consequently, HIV-1 genomes are copied with the host cell DNA during cellular division.
Externí odkaz:
https://doaj.org/article/24168db87d274281ba8cf37cddd5815b
Autor:
Eva M. Stevenson, Adam R. Ward, Ronald Truong, Allison S. Thomas, Szu-Han Huang, Thomas R. Dilling, Sandra Terry, John K. Bui, Talia M. Mota, Ali Danesh, Guinevere Q. Lee, Andrea Gramatica, Pragya Khadka, Winiffer D. Conce Alberto, Rajesh T. Gandhi, Deborah K. McMahon, Christina M. Lalama, Ronald J. Bosch, Bernard Macatangay, Joshua C. Cyktor, Joseph J. Eron, John W. Mellors, R. Brad Jones, for the AIDS Clinical Trials Group A5321 Team
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Antiretroviral therapies (ARTs) abrogate HIV replication; however, infection persists as long-lived reservoirs of infected cells with integrated proviruses, which reseed replication if ART is interrupted. A central tenet of our current understanding
Externí odkaz:
https://doaj.org/article/fb50f24e6e51492997ce0b7e07385aef
Autor:
Adam R, Ward, Allison S, Thomas, Eva M, Stevenson, Szu-Han, Huang, Sheila M, Keating, Rajesh T, Gandhi, Deborah K, McMahon, Ronald J, Bosch, Bernard J, Macatangay, Joshua C, Cyktor, Joseph J, Eron, John W, Mellors, R Brad, Jones
Publikováno v:
AIDS. 36:1617-1628
People with HIV (PWH) have persistently elevated levels of inflammation and immune activation despite suppressive antiretroviral therapy (ART), with specific biomarkers showing associations with non-AIDS-defining morbidities and mortality. We investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ef5b5bac209cedcce6bfe8e1b20f4e
https://doi.org/10.1097/qad.0000000000003301
https://doi.org/10.1097/qad.0000000000003301
Autor:
Ronald J, Bosch, Rajesh T, Gandhi, Hanna, Mar, Joseph J, Eron, Joshua C, Cyktor, Deborah K, McMahon, John W, Mellors
Publikováno v:
J Infect Dis
Clinical research to achieve antiretroviral therapy-free remission requires quantitative assays of the HIV-1 reservoir. Intact proviral DNA (IPD) measurement has greater throughput than the quantitative viral outgrowth assay (QVOA). In 25 individuals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625d053047f88615a26278e4ee919a98
https://doi.org/10.1093/infdis/jiac030
https://doi.org/10.1093/infdis/jiac030
Autor:
Curtis Dobrowolski, Michael F. Para, Jonathan Karn, Joshua C. Cyktor, Edward P. Acosta, Ronald T. Mitsuyasu, Joseph Hesselgesser, Joan Dragavon, Evgenia Aga, Rajesh T. Gandhi, Bernard J.C. Macatangay, John W. Mellors, Deborah McMahon, Catherine Godfrey, Lu Zheng
Publikováno v:
J Infect Dis
Background Romidepsin (RMD) is a histone deacetylase inhibitor reported to reverse HIV-1 latency. We sought to identify doses of RMD that were safe and induced HIV-1 expression. Methods Enrollees had HIV-1 RNA Results In the single-dose cohorts 1–3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a234f1b2b2d2524ea5ab6ea78e5f3f29
https://doi.org/10.1093/infdis/jiaa777
https://doi.org/10.1093/infdis/jiaa777
Autor:
Du-San Baek, Ye-Jin Kim, Wei Li, Bernard JC Macatangay, Joshua C. Cyktor, Margaret G. Hines, John W. Mellors, Dimiter S. Dimitrov
NK and CD8+ T cells are important cells for cytolysis of cancer cells. The tumor microenvironment can upregulate surface expression on these cells of NKG2A, an inhibitory receptor that can dampen immune responses to cancer leading to immune evasion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::493b1b47c2832a10ae7878c723d11b91
https://doi.org/10.1101/2022.05.18.492494
https://doi.org/10.1101/2022.05.18.492494
