Výsledky vyhledávání - "Joshua C. Bunger"

Akademický článek

Reduced Toxicity of Shiga Toxin (Stx) Type 2c in Mice Compared to Stx2d Is Associated with Instability of Stx2c Holotoxin

Autor: Joshua C. Bunger, Angela R. Melton-Celsa, Ernest L. Maynard, Alison D. O'Brien

Publikováno v: Toxins, Vol 7, Iss 6, Pp 2306-2320 (2015)

Shiga toxin (Stx) is an AB5 ribotoxin made by Stx-producing Escherichia coli (STEC). These organisms cause diarrhea, hemorrhagic colitis and the hemolytic uremic syndrome. STEC make two types of Stxs, Stx1 and/or Stx2. Stx2 has one prototype (a) and

Externí odkaz: https://doaj.org/article/cf9e0ffa42d5448091014797f8f09e4b

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Akademický článek

Shiga Toxin Type 2dact Displays Increased Binding to Globotriaosylceramide in vitro and Increased Lethality in Mice after Activation by Elastase

Autor: Alison D. O'Brien, Angela R. Melton-Celsa, Joshua C. Bunger

Publikováno v: Toxins, Vol 5, Iss 11, Pp 2074-2092 (2013)

Shiga toxin type 2dact (Stx2dact), an Stx2 variant originally identified from Escherichia coli O91:H21 strain B2F1, displays increased cytotoxicity after activation by elastase present in intestinal mucus. Activation is a result of cleavage of two am

Externí odkaz: https://doaj.org/article/52e016e3c7c74d66abb701a48a88a5e1

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Drug-associated changes in amino acid residues in Gag p2, p7NC, and p6Gag/p6Pol in human immunodeficiency virus type 1 (HIV-1) display a dominant effect on replicative fitness and drug response

Autor: Joshua C. Bunger, Isabel Munoz, Maureen M. Goodenow, Stephanie L. Rose, Roxana M. Coman, Patricia O. O'Brien, Sarah K. Ho, John W. Sleasman, Ben M. Dunn

Publikováno v: Virology. 378(2):272-281

Regions of HIV-1 gag between p2 and p6(Gag)/p6(Pol), in addition to protease (PR), develop genetic diversity in HIV-1 infected individuals who fail to suppress virus replication by combination protease inhibitor (PI) therapy. To elucidate functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46edc04ac91096a06191e6901725521

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Shiga toxin type 2dact displays increased binding to globotriaosylceramide in vitro and increased lethality in mice after activation by elastase

Autor: Joshua C. Bunger, Angela R. Melton-Celsa, Alison D. O'Brien

Publikováno v: Toxins
Toxins, Vol 5, Iss 11, Pp 2074-2092 (2013)
Volume 5
Issue 11
Pages 2074-2092

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2979f129079d4167b1b4ad3b0217e7a
https://pubmed.ncbi.nlm.nih.gov/24217397

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HIV-1 primes macrophages while evading Toll-Like Receptor (TLR) signaling: A systems biology approach

Autor: Joshua C. Bunger, John W. Sleasman, Mark A. Wallet, Maureen M. Goodenow, Joseph N. Brown

Publikováno v: Cytokine. 48:9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f074b80bb92151e2a026ba6fadb2ecb
https://doi.org/10.1016/j.cyto.2009.07.036

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