Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joshua C Wallington"'
Autor:
Grace E Cooper, Zoe C Pounce, Joshua C Wallington, Leidy Y Bastidas-Legarda, Ben Nicholas, Chiamaka Chidomere, Emily C Robinson, Kirstin Martin, Anna S Tocheva, Myron Christodoulides, Ratko Djukanovic, Tom M A Wilkinson, Karl J Staples
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163889 (2016)
Macrophages are essential to maintaining lung homoeostasis and recent work has demonstrated that influenza-infected lung macrophages downregulate their expression of the scavenger receptor CD36. This receptor has also been shown to be involved in pha
Externí odkaz:
https://doaj.org/article/e639ce5ada424e8988e2486263a2fc68
Autor:
Karl J Staples, Ben Nicholas, Richard T McKendry, C Mirella Spalluto, Joshua C Wallington, Craig W Bragg, Emily C Robinson, Kirstin Martin, Ratko Djukanović, Tom M A Wilkinson
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121527 (2015)
Lung macrophages are an important defence against respiratory viral infection and recent work has demonstrated that influenza-induced macrophage PDL1 expression in the murine lung leads to rapid modulation of CD8+ T cell responses via the PD1 recepto
Externí odkaz:
https://doaj.org/article/7d746146d0234b05942328a759da58d1
Autor:
Daniel Horowitz, Peter H. Howarth, Joshua C. Wallington, Ratko Djukanovic, Timothy S. C. Hinks, Christopher H. Woelk, Stephan D. Gadola, Karl J. Staples, Caroline Smith, Akul Singhania
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:261-270
Asthma arises from the complex interplay of inflammatory pathways in diverse cell types and tissues. We sought to undertake a comprehensive transcriptomic assessment of the epithelium and airway T cells that remain understudied in asthma and investig
Publikováno v:
Respiratory Infections.
Non-typeable Haemophilus influenzae (NTHi) is an important respiratory pathogen and is highly associated with exacerbations of chronic obstructive pulmonary disease (COPD). Cell-mediated immunity may be key to controlling infection, but the responses
Publikováno v:
Respiratory Infections.
Infection by certain bacterial species can predispose an individual to developing asthma and trigger asthmatic exacerbations. Moraxella catarrhalis is one such organism, yet there is little data on the innate immune responses to this pathogen. Alveol
Publikováno v:
The Journal of allergy and clinical immunology. 141(6)
Background Bacterial respiratory tract infections and exacerbations of chronic lung diseases are commonly caused by nontypeable Haemophilus influenzae (NTHi). Cell-mediated cytotoxicity might be key to controlling infection, but the responses of NTHi
Autor:
Ratko Djukanovic, Tom Wilkinson, Timothy S. C. Hinks, Karl J. Staples, Anthony P. Williams, Joshua C. Wallington
RATIONALE: Mucosal-associated invariant T (MAIT) cells are a recently described abundant, proinflammatory T-cell subset with unknown roles in pulmonary immunity. Nontypeable Haemophilus influenzae (NTHi) is the leading bacterial pathogen during chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc88ce63ef71ef1ff61ef753564fe90d
https://eprints.soton.ac.uk/393511/
https://eprints.soton.ac.uk/393511/
Publikováno v:
10.1 Respiratory Infections.
The airways of patients with COPD are commonly colonised by non-typeable Haemophilus influenzae (NTHi). Despite being increased in the COPD airway, CD8+ T cells appear unable to clear NTHi infection, contributing to exacerbations of COPD and promotin
Autor:
Karl J. Staples, C. Mirella Spalluto, Joshua C. Wallington, Tom Wilkinson, Jane Warner, Andrew J. Hutton, Chris Pickard, Marta E Polak
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 198(1)
Lung fibroblasts are key structural cells that reside in the submucosa where they are in contact with large numbers of CD4+ Th cells. During severe viral infection and chronic inflammation, the submucosa is susceptible to bacterial invasion by lung m
Autor:
Richard T. McKendry, Karl J. Staples, Anthony P. Williams, Joshua C. Wallington, Tom Wilkinson
Publikováno v:
10.1 Respiratory Infections.
Non-typeable Haemophilus influenzae (NTHi) is frequently found in the COPD airway and is strongly associated with recurrent exacerbations. Although increased numbers of CD8+ T cells are present in the COPD airway, the response of NTHi-specific CD8+ p