Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joshua Broyde"'
Autor:
Kaja Kostyrko, Marta Román, Alex G. Lee, David R. Simpson, Phuong T. Dinh, Stanley G. Leung, Kieren D. Marini, Marcus R. Kelly, Joshua Broyde, Andrea Califano, Peter K. Jackson, E. Alejandro Sweet-Cordero
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract KRAS is a frequent driver in lung cancer. To identify KRAS-specific vulnerabilities in lung cancer, we performed RNAi screens in primary spheroids derived from a Kras mutant mouse lung cancer model and discovered an epigenetic regulator Ubiq
Externí odkaz:
https://doaj.org/article/bfd9eceda508466c9e02d6a2c91e89f7
Autor:
Kaja Kostyrko, Alex Lee, Marta Román, David Simpson, Phuong Dinh, Stanley Leung, Kieren Marini, Marcus Kelly, Joshua Broyde, Andrea Califano, Peter Jackson, Alejandro Sweet-Cordero
KRAS is one of the most frequently mutated oncogenes in lung cancer. To identify novel KRAS-specific vulnerabilities, we performed RNAi screens in spheroid cultures of primary tumor cells derived from a mouse model of lung cancer driven by activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c97373194352df4bcd17d3bacafaeddb
https://doi.org/10.21203/rs.3.rs-1651106/v1
https://doi.org/10.21203/rs.3.rs-1651106/v1
Autor:
Barry Honig, Diana Murray, Alexander Lachmann, Peter K. Jackson, David R. Simpson, Andrea Califano, E. Alejandro Sweet-Cordero, Sunny J. Jones, Somnath Tagore, Brennan Chu, Evan O. Paull, Federico M. Giorgi, Joshua Broyde, Aaron T. Griffin
Publikováno v:
Nature biotechnology, vol 39, iss 2
Nat Biotechnol
Nat Biotechnol
Tumor-specific elucidation of physical and functional oncoprotein interactions could improve tumorigenic mechanism characterization and therapeutic response prediction. Current interaction models and pathways, however, lack context specificity and ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d750cb705059dd4f64232fd4130928bd
http://hdl.handle.net/11585/785854
http://hdl.handle.net/11585/785854
Autor:
Andrea Califano, Federico M. Giorgi, E. Alejandro Sweet-Cordero, Barry Honig, Diana Murray, Peter K. Jackson, David R. Simpson, Alexander Lachmann, Joshua Broyde
The largely incomplete and tissue-independent nature of cancer pathways represents a key limitation to the ability to elucidate mechanistic determinants of cancer phenotypes and to predict adaptive response to targeted therapy. To address these chall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe04232ca62dc4f17af0362a313792cc
https://doi.org/10.1101/289538
https://doi.org/10.1101/289538
Autor:
Raymond F. Schinazi, James H. Nettles, Steven J. Coats, Hongwang Zhang, Tamara R. McBrayer, Longhu Zhou, Joshua Broyde, Richard A. Stanton, Junxing Shi, James J. Kohler, Tony Whitaker, Franck Amblard
Publikováno v:
Journal of Medicinal Chemistry
Symmetric, dimeric daclatasvir (BMS-790052) is the clinical lead for a class of picomolar inhibitors of HCV replication. While specific, resistance-bearing mutations at positions 31 and 93 of domain I strongly suggest the viral NS5A as target, struct
Autor:
Xiaowei Chen, Courtney W. Houchen, Helen Remotti, Andrea Califano, Richard A. Friedman, Yoku Hayakawa, Yoshihiro Takemoto, Marina Macchini, Gloria H. Su, Zhengyu Jiang, Bernhard W. Renz, Youngjin Cho, Daniel L. Worthley, Karan Nagar, Samuel Asfaha, Anil K. Rustgi, Maximilian Reichert, Steffen Ormanns, Barry Honig, Joshua Broyde, Aleksandra M. Urbanska, Timothy C. Wang, Takayuki Tanaka, Michael Quante, C. Benedikt Westphalen, Kenneth P. Olive, Randal May, Prem S. Subramaniam, Yagnesh Tailor
Publikováno v:
Paediatrics Publications
Colorectal carcinogenesis is a multi-step process. While ~25% of colorectal cancers (CRCs) arise in patients with a family history (genetic predisposition), ~75% of CRCs are due to age-associated accumulation of epigenetic alterations which can resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea9711b10bf0cc35d89e0fc8ee0f24b
https://ir.lib.uwo.ca/context/paedpub/article/1710/viewcontent/S1934_5909_16_30003_0.pdf
https://ir.lib.uwo.ca/context/paedpub/article/1710/viewcontent/S1934_5909_16_30003_0.pdf
Autor:
Barry Honig, David R. Simpson, Kaja Kostyrko, Joshua Broyde, Marcus R. Kelly, Andrea Califano, Peter K. Jackson, Alejandro Sweet-Cordero
Publikováno v:
Molecular Cancer Therapeutics. 16:A27-A27
Lung cancer is the number one cause of cancer-related deaths worldwide. The most prevalent type of lung cancer is Non-Small Cell Lung Cancer (NSCLC). A significant number of patients with NSCLC carry oncogenic KRAS mutations. However, the efforts to
Autor:
Andrea Califano, Barry Honig, David L. Simpson, Alexander Lachmann, Joshua Broyde, Alejandro Sweet-Cordero, Federico M. Giorgi, Diana Murray
Publikováno v:
Cancer Research. 77:LB-289
Elucidation of the full complement of members of oncogenic signaling pathways is critical for understanding dysregulated function in cancers. Our knowledge of experimentally verified human gene-regulatory networks and protein-protein interactions rem
Autor:
David R. Simpson, Alexander Lachmann, Alejandro Sweet-Cordero, Joshua Broyde, Antonina Silkov, Marc Vidal, Andrea Califano, David E. Hill, Donald Petrey, Mariano J. Alvarez, Federico M. Giorgi, Barry Honig, David A. Wah, Peter K. Jackson
Publikováno v:
Cancer Research. 75:PR13-PR13
Activated KRAS interacts directly and indirectly with numerous downstream effector pathways that are still elusive or poorly characterized. Furthermore, it has become clear over the past few years that the KRAS regulatory gene network (interactome) i