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pro vyhledávání: '"Joshua Bolger"'
Autor:
David R. Snead, Yonghong Gan, Thomas Scattolin, Dinesh J. Paymode, Michal Achmatowicz, Duane E. Rudisill, Ephraim S. Vidal, Tawfik Gharbaoui, Phil Roberts, Jianbo Yang, Zhangbing Shi, Wei Liu, Joshua Bolger, Zhen Qiao, Cheng-yi Chen
Publikováno v:
Organic Process Research & Development. 27:530-538
A commercial route to MRTX849 (adagrasib) was developed to support clinical and commercial needs. Yield was improved to 32% over six chemical steps. A doubly regioselective SNAr reduced consumption of an expensive chiral intermediate, reaction optimi
Autor:
Joshua Bolger, Marvin J. Miller
Publikováno v:
ChemInform. 42
Regioselective copper-catalyzed ring-opening alkylation of cycloadducts such as (I) with chloride (II) is optimized and applied to the synthesis of the phenolic intermediate (V), which serves as starting material for a series of potential inhibitors
Publikováno v:
Organicbiomolecular chemistry. 9(8)
Acylnitroso cycloadducts have proven to be valuable intermediates in the syntheses of a plethora of biologically active molecules. Recently, organometallic reagents were shown to open bicyclic acylnitroso cycloadducts and, more interestingly, the pro