Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Joshua Beilke"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population can develop in the thymus and in the peripheral tissues of the immune
Externí odkaz:
https://doaj.org/article/fd9bc801b57a4ba9a6794b2dcbbd0420
Autor:
Andrew Dervan, Matthew Trotter, Christopher Mark Hill, Brian Fox, Hamid Bolouri, Alexander V. Ratushny, Anne-Renee van der Vuurst de Vries, Joshua Beilke, Pallavur Sivakumar, Paul Shannon, Rebecca Johnson, Mary Young, Lu Huang, Douglas Bassett, C.C. Santini
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Failure to clear antigens causes CD8+ T cells to become increasingly hypo-functional, a state known as exhaustion. We combined manually extracted information from published literature with gene expression data from diverse model systems to infer a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c710102aeb2ce4874d47ec577d38fe37
Autor:
Ramesh Natarajan, Mohammad Afzal Khan, Joshua Beilke, Mervin C. Yoder, Mark R. Nicolls, Gregg L. Semenza, Xinguo Jiang, Jon C. Kosek, Wen Tian
Publikováno v:
Journal of Clinical Investigation. 121:2336-2349
Chronic rejection, manifested as small airway fibrosis (obliterative bronchiolitis [OB]), is the main obstacle to long-term survival in lung transplantation. Recent studies demonstrate that the airways involved in a lung transplant are relatively hyp
Publikováno v:
Proceedings of the National Academy of Sciences. 107:15844-15849
Resting natural killer (NK) cells in nonobese diabetic (NOD) mice have impaired immune functions compared with NK cells from other mouse strains. Here we investigated how NOD NK cells respond after mouse cytomegalovirus (MCMV) infection, using NOD mi
Autor:
Jing He, Joshua Beilke, Suzanne Bertera, Hubert M. Tse, Rita Bottino, Ronald G. Gill, Massimo Trucco, James D. Crapo, Jon D. Piganelli, Martha M. Sklavos, Marilyne Coulombe
Publikováno v:
Diabetes
OBJECTIVEBecause of reduced antioxidant defenses, β-cells are especially vulnerable to free radical and inflammatory damage. Commonly used antirejection drugs are excellent at inhibiting the adaptive immune response; however, most are harmful to isl
Publikováno v:
Nature
In an adaptive immune response, naïve T cells proliferate during infection and generate long-lived memory cells that undergo secondary expansion following re-encounter with the same pathogen. Although Natural Killer cells traditionally have been cla
Autor:
Ronald G. Gill, Joshua Beilke
Publikováno v:
Journal of the American Society of Nephrology. 18:2262-2267
Natural killer (NK) cells are recognized for providing an important early innate immune response to viral and bacterial pathogens and for the surveillance of stressed and transformed autologous cells. However, with the exception of a pronounced role
Autor:
Ronald G. Gill, George S. Eisenbarth, Joshua Beilke, Maki Nakayama, Marcella Li, John F. Elliott, Jean Jasinski, Masakazu Kobayashi, Edwin Liu, Dongmei Miao, Marilyne Coulombe
Publikováno v:
Journal of Clinical Investigation. 117:1835-1843
NOD mice with knockout of both native insulin genes and a mutated proinsulin transgene, alanine at position B16 in preproinsulin (B16:A-dKO mice), do not develop diabetes. Transplantation of NOD islets, but not bone marrow, expressing native insulin
Autor:
Rene Kupfer, Diane G Gutches, Joshua Beilke, Dale R. Wegmann, Robert I. Scheinman, William Wheat, Gina R. Rayat
Publikováno v:
European Journal of Immunology. 34:1395-1404
Type 1 diabetes results from the breakdown of peripheral tolerance. As regulators of T cell activation, antigen-presenting cells (APC) modulate peripheral tolerance and hence contribute to the immune dysregulation characteristic of insulin-dependent
Autor:
Christopher J. Hogan, Jing W. Zhu, Jeffery S. Tessem, Joshua Beilke, Jan Jensen, James DeGregori, Marileila Varella-Garcia, Feng X. Li
Publikováno v:
Proceedings of the National Academy of Sciences. 100:12935-12940
Our studies of mice deficient for the E2F1 and E2F2 transcription factors have revealed essential roles for these proteins in the cell cycle control of pancreatic exocrine cells and the regulation of pancreatic beta cell maintenance. Pancreatic exocr