Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Joshua Ballard"'
Autor:
Geoffrey R. Oxnard, Satoshi Yoda, Bruce G. Robinson, Eliana B. Gomez, Sarah-Jane Dawson, S. Michael Rothenberg, Justin F. Gainor, Dahlia Henry, Oliver Gautschi, Christine Khoo, Stephen Q. Wong, Edward Y. Zhu, Andrew T. Metcalf, Louis Stancato, Brian B. Tuch, Barbara J. Brandhuber, Steve Andrews, Jessica J. Lin, Lavinia Tan, Kevin Ronald Condroski, Vivek Subbiah, Lecia V. Sequist, Wayne Blosser, James F. Blake, Joshua Ballard, Kolakowski Gabrielle R, Kevin Ebata, Alexander Drilon, Benjamin Solomon, Michele Nguyen, Sebastian Hollizeck
Publikováno v:
Journal of Thoracic Oncology. 15:541-549
Introduction Novel rearranged in transfection (RET)-specific tyrosine kinase inhibitors (TKIs) such as selpercatinib (LOXO-292) have shown unprecedented efficacy in tumors positive for RET fusions or mutations, notably RET fusion-positive NSCLC and R
Autor:
Joshua Ballard, Harrah Chiang, James G. Christensen, Kenneth Hee, Tony Pisal Tang, Brian R. Baer, Peter Olson, Henry J. Zecca, David Briere, Mark Joseph Chicarelli, Laurence E. Burgess, Karyn Bouhana, Jill Hallin, Matthew A. Marx, Lauren Hanson, Barbara J. Brandhuber, Michael Burkard, Fell Jay Bradford, Pavel Savechenkov, James F. Blake, John P. Fischer, Guy Vigers, Hicken Erik James, Niranjan Sudhakar, Kevin Davidson, Ronald Jay Hinklin, Macedonio J. Mejia, John Gaudino
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1230-1234
[Image: see text] KRAS is the most frequently mutated driver oncogene in human cancer, and KRAS mutations are commonly associated with poor prognosis and resistance to standard treatment. The ability to effectively target and block the function of mu
Autor:
James G. Christensen, Macedonia J. Mejia, Tony Pisal Tang, Joshua Ballard, Pavel Y. Savechenkov, Mark Joseph Chicarelli, Guy Vigers, Niranjan Sudhakar, James F. Blake, Peter D. Olson, Brian R. Baer, David Briere, Matthew A. Marx, Fell Jay Bradford, Michael R. Burkhard, Karyn Bouhana, Laurence E. Burgess, Jill Hallin, Harrah Chiang, John P. Fischer
Publikováno v:
Molecular Cancer Research. 18:B30-B30
The ability to effectively target mutated KRAS has remained elusive despite decades of research. By solving a highly informative set of ligand-complexed co-crystal structures coupled with iterative structure-based drug design, substituted tetrahydrop
Autor:
Kevin Ronald Condroski, Kolakowski Gabrielle R, Thomas C. Irvin, Nisha A. Patel, Manoj Kumar, Joshua Ballard, Erin D. Anderson, Andrews Steven W, Eliana B. Gomez, Barbara J. Brandhuber, Faith D. Watson
Publikováno v:
Cancer Research. 81:1464-1464
In May 2020, selpercatinib became the first FDA-approved selective RET inhibitor, indicated for patients (pts) with RET fusion-positive NSCLC and thyroid cancer as well as RET-mutant medullary thyroid cancer. Despite the durable activity of selpercat
Autor:
Ruben J. Fair, Joshua Ballard, Renuka Rajput-Ghoshal, Latifa Elouadrhiri, Robert A. Legg, J. Hogan, W. Schneider, C. H. Rode, George H. Biallas, Cesar Luongo, Glenn Young, Probir K. Ghoshal, Mark Wiseman, D. Kashy
Publikováno v:
IEEE Transactions on Applied Superconductivity. 25:1-5
As part of the Jefferson Lab 12 GeV accelerator upgrade project, Hall B requires two conduction cooled superconducting magnets. One is a magnet system consisting of six superconducting trapezoidal racetrack-type coils assembled in a toroidal configur
Autor:
Leonid Beigelman, Hailong Zhang, Benjamin T. Woodard, Christine Lemieux, Guy Vigers, Vlad Serebryany, Brad O. Buckman, Bin Wang, Scott D. Seiwert, Barbra J. Brandhuber, Steve Wenglowsky, Stengel Peter J, Andrews Steven W, Lawrence M. Blatt, Kennedy April L, Doherty George Andrew, John A. Josey, Joshua Ballard, Mary Geck Do, Madduru Machender R, Jiang Yutong, Kevin Ronald Condroski, Michael Lyon
Publikováno v:
Journal of Medicinal Chemistry. 57:1753-1769
HCV serine protease NS3 represents an attractive drug target because it is not only essential for viral replication but also implicated in the viral evasion of the host immune response pathway through direct cleavage of key proteins in the human inna
Publikováno v:
Fair Disclosure Wire (Quarterly Earnings Reports). 05/01/2024.
Autor:
Lori Friedman, Nicholas J. Skelton, Kui Lin, Susan L. Gloor, Joshua Ballard, Guy Vigers, Wen-I Wu, Tony Morales, Barbara J. Brandhuber, Jie Lin, Brian Lee
Publikováno v:
Science Signaling. 5
The protein serine-threonine kinase Akt undergoes a substantial conformational change upon activation, which is induced by the phosphorylation of two critical regulatory residues, threonine 308 and serine 473. Paradoxically, treating cells with adeno
Autor:
Joshua Ballard, Thomas Carstens, Yi Qiang, J. Creel, Mark Stevens, Mark Wissmann, George H. Biallas, Paul Brindza, F. Martin, Hovanes Egiyan, Elliott Wolin, Scot Spiegel
Publikováno v:
AIP Conference Proceedings.
Thomas Jefferson National Accelerator Facility (JLab) refurbished the Large Aperture Solenoid Spectrometer (LASS) [1], 1.85 m bore solenoid, consisting of four superconducting coils to act as the principal analysis magnet for nuclear physics in the n
Autor:
Aykut Üren, Stephen G. Brohawn, Eva Muñoz, Kenneth Miller, Mike Scott, Heather Hughes, Yasmina Noubia Abdiche, Rohn Lee Millican, Anne W Emerick, Jonathan Brooks, Michael B. Murphy, Charlene S. Lee, Carmelo Di Primo, Joshua Ballard, Quyhn Trinh, Giuseppe A. Papalia, Cynthia S. Hinck, Kevin Thompson, Peter Flynn, Joshua S. Klein, Martin A. Wear, Mark Toews, Richard N. Bohnsack, Mohammed Yousef, Daniel Malashock, Gaetano Barbato, Jill Raymond, Alison Joyce, Min Hsiang Yang, Julie Rothacker, Patrick England, Ashique Rafique, Jacinto López-Sagaseta, Scott L. Klakamp, Daulet Satpaev, Monica Dines, Danny Terwey, Islay Campbell, Joshua Thompson, Ben Busby, Tanmoy Ganguly, Gerardo Gutierrez-Sanchez, Sergei Shikov, Kevin Lindquist, Momchilo Vuyisich, Asya Grinberg, Krista Witte, Yun Hee Cho, Yue Ji Li, Hubert Mantz, Ewa Pol, Gonzalo Obal, Brian J. Pak, María J. Hernáiz, Peter Kainz, Erk Gedig, Mary M. Murphy, Tsafir Bravman, Janus Krarup, Gabrielle Zeder-Lutz, John Quinn, Thomas E. Ryan, Pietro Brandani, Dawn Kernaghan, Anca Clabbers, M. Brent Waddell, Agnes Puskas, Petr Skládal, Sanjay Nilapwar, Kara Herlihy, Gregor Anderluh, Federico Torta, Eric Hommema, Andrej Bavdek, Rejane Guimaraes, Anthony M. Giannetti, Eric Fang, Henrik Anderson, Anne Birgitte Bagge Hagel, Schuyler B Corry, Mark R. Witmer, Phillippe Neuner, Sébastien Wieckowski, Nico Dankbar, Alanna Pinkerton, Suparna Mundodo, Trevor D. Chapman, Sylvie Canepa, Satya P. Yadav, Rostislav Skrabana, Oleksandr Kalyuzhniy, Phini S Katsamba, Vidya Chandrasekaran, Eugene G. Chomey, Dana Reichmann, Katy McGirr, Dotzlaf Joe Edward, Mireille Baltzinger, Ite A. Laird-Offringa, Liann Wang, Erica Boni, Tiffany Tsang, Zaneta Nikolovska-Coleska, Andreas Schoenemann, Yuki Abe, Jamie Furneisen, Kenneth T. Lewis, Eileen M. Lafer, John Corbin, Satyen Gautam, Yuguo Feng, Olan Dolezal, Sylviane Hoos, James R. Horn, Bianca Beusink, Jinlin Peng, Otto Pritsch, Kristian H. Schlick, Ryan James Darling, Malgorzata Mikolajczyk, Quincy L. Carter, Jason T. Schuman, Yang Liu, Abdelkrim Khadir, Loïc Martin, Mark Alan Lewis, Ganeshram Krishnamoorthy, Andrew W. Drake, Jason Baardsnes, George Korza, Jesper Pass, Judie Berlier, Melicia Gainey, Nguyen Ly, James R. Partridge, Rosy Calvert, Roberta D'Agata, Rebecca L. Rich, Monica E. Ferreira, Phillip Page, Frank John Podlaski, Jay Duffner, Ruchira Das Gupta, Melanie Wong, Sergei Bibikov, Jiejin Li, Paola Torreri, Bruce A. Andrien, Peter Spies, Christina Boozer, David G. Myszka
Publikováno v:
Analytical Biochemistry
Analytical Biochemistry, Elsevier Masson, 2009, 386 (2), pp.194-216. ⟨10.1016/j.ab.2008.11.021⟩
Analytical biochemistry, 386(2):10.1016/j.ab.2008.11.021, 194-216. Academic Press Inc.
Analytical Biochemistry, 2009, 386 (2), pp.194-216. ⟨10.1016/j.ab.2008.11.021⟩
Rich, R L, Papalia, G A, Flynn, P J, Furneisen, J, Quinn, J, Klein, J S, Katsamba, P S, Waddell, M B, Scott, M, Thompson, J, Berlier, J, Corry, S, Baltzinger, M, Zeder-Lutz, G, Schoenemann, A, Clabbers, A, Wieckowski, S, Murphy, M M, Page, P, Ryan, T E, Duffner, J, Ganguly, T, Corbin, J, Gautam, S, Anderluh, G, Bavdek, A, Reichmann, D, Yadav, S P, Hommema, E, Pol, E, Drake, A, Klakamp, S, Chapman, T, Kernaghan, D, Miller, K, Schuman, J, Lindquist, K, Herlihy, K, Murphy, M B, Bohnsack, R, Andrien, B, Brandani, P, Terwey, D, Millican, R, Darling, R J, Wang, L, Carter, Q, Dotzlaf, J, Lopez-Sagaseta, J, Campbell, I, Torreri, P, Hoos, S, England, P, Liu, Y, Abdiche, Y, Malashock, D, Pinkerton, A, Wong, M, Lafer, E, Hinck, C, Thompson, K, Primo, C D, Joyce, A, Brooks, J, Torta, F, Bagge Hagel, A B, Krarup, J, Pass, J, Ferreira, M, Shikov, S, Mikolajczyk, M, Abe, Y, Barbato, G, Giannetti, A M, Krishnamoorthy, G, Beusink, B, Satpaev, D, Tsang, T, Fang, E, Partridge, J, Brohawn, S, Horn, J, Pritsch, O, Obal, G, Nilapwar, S, Busby, B, Gutierrez-Sanchez, G, Gupta, R D, Canepa, S, Witte, K, Nikolovska-Coleska, Z, Cho, Y H, D'Agata, R, Schlick, K, Calvert, R, Munoz, E M, Hernaiz, M J, Bravman, T, Dines, M, Yang, M-H, Puskas, A, Boni, E, Li, J, Wear, M, Grinberg, A, Baardsnes, J, Dolezal, O, Gainey, M, Anderson, H, Peng, J, Lewis, M, Spies, P, Trinh, Q, Bibikov, S, Raymond, J, Yousef, M, Chandrasekaran, V, Feng, Y, Emerick, A, Mundodo, S, Guimaraes, R, McGirr, K, Li, Y-J, Hughes, H, Mantz, H, Skrabana, R, Witmer, M, Ballard, J, Martin, L, Skladal, P, Korza, G, Laird-Offringa, I, Lee, C S, Khadir, A, Podlaski, F, Neuner, P, Rothacker, J, Rafique, A, Dankbar, N, Kainz, P, Gedig, E, Vuyisich, M, Boozer, C, Ly, N, Toews, M, Uren, A, Kalyuzhniy, O, Lewis, K, Chomey, E, Pak, B J & Myszka, D G 2009, ' A global benchmark study using affinity-based biosensors ', Analytical Biochemistry, vol. 386, no. 2, pp. 194-216 . https://doi.org/10.1016/j.ab.2008.11.021
Analytical Biochemistry, Elsevier Masson, 2009, 386 (2), pp.194-216. ⟨10.1016/j.ab.2008.11.021⟩
Analytical biochemistry, 386(2):10.1016/j.ab.2008.11.021, 194-216. Academic Press Inc.
Analytical Biochemistry, 2009, 386 (2), pp.194-216. ⟨10.1016/j.ab.2008.11.021⟩
Rich, R L, Papalia, G A, Flynn, P J, Furneisen, J, Quinn, J, Klein, J S, Katsamba, P S, Waddell, M B, Scott, M, Thompson, J, Berlier, J, Corry, S, Baltzinger, M, Zeder-Lutz, G, Schoenemann, A, Clabbers, A, Wieckowski, S, Murphy, M M, Page, P, Ryan, T E, Duffner, J, Ganguly, T, Corbin, J, Gautam, S, Anderluh, G, Bavdek, A, Reichmann, D, Yadav, S P, Hommema, E, Pol, E, Drake, A, Klakamp, S, Chapman, T, Kernaghan, D, Miller, K, Schuman, J, Lindquist, K, Herlihy, K, Murphy, M B, Bohnsack, R, Andrien, B, Brandani, P, Terwey, D, Millican, R, Darling, R J, Wang, L, Carter, Q, Dotzlaf, J, Lopez-Sagaseta, J, Campbell, I, Torreri, P, Hoos, S, England, P, Liu, Y, Abdiche, Y, Malashock, D, Pinkerton, A, Wong, M, Lafer, E, Hinck, C, Thompson, K, Primo, C D, Joyce, A, Brooks, J, Torta, F, Bagge Hagel, A B, Krarup, J, Pass, J, Ferreira, M, Shikov, S, Mikolajczyk, M, Abe, Y, Barbato, G, Giannetti, A M, Krishnamoorthy, G, Beusink, B, Satpaev, D, Tsang, T, Fang, E, Partridge, J, Brohawn, S, Horn, J, Pritsch, O, Obal, G, Nilapwar, S, Busby, B, Gutierrez-Sanchez, G, Gupta, R D, Canepa, S, Witte, K, Nikolovska-Coleska, Z, Cho, Y H, D'Agata, R, Schlick, K, Calvert, R, Munoz, E M, Hernaiz, M J, Bravman, T, Dines, M, Yang, M-H, Puskas, A, Boni, E, Li, J, Wear, M, Grinberg, A, Baardsnes, J, Dolezal, O, Gainey, M, Anderson, H, Peng, J, Lewis, M, Spies, P, Trinh, Q, Bibikov, S, Raymond, J, Yousef, M, Chandrasekaran, V, Feng, Y, Emerick, A, Mundodo, S, Guimaraes, R, McGirr, K, Li, Y-J, Hughes, H, Mantz, H, Skrabana, R, Witmer, M, Ballard, J, Martin, L, Skladal, P, Korza, G, Laird-Offringa, I, Lee, C S, Khadir, A, Podlaski, F, Neuner, P, Rothacker, J, Rafique, A, Dankbar, N, Kainz, P, Gedig, E, Vuyisich, M, Boozer, C, Ly, N, Toews, M, Uren, A, Kalyuzhniy, O, Lewis, K, Chomey, E, Pak, B J & Myszka, D G 2009, ' A global benchmark study using affinity-based biosensors ', Analytical Biochemistry, vol. 386, no. 2, pp. 194-216 . https://doi.org/10.1016/j.ab.2008.11.021
International audience; To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a protein system that was amen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f0511d7d5e8ed6e3424eec0c582e12
https://hal.archives-ouvertes.fr/hal-01527917
https://hal.archives-ouvertes.fr/hal-01527917