Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joshua B. Owen"'
Autor:
Jean-Christophe Peter, Marjorie Weckering, Karl G. Hofbauer, William A. Banks, Géraldine Zipfel, Helene Rossez, Anne-Catherine Lecourt, Joshua B. Owen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle
Background Cachexia is a complex syndrome defined by weight loss due to an ongoing loss of skeletal muscle mass with or without loss of body fat. It is often associated with anorexia. Numerous results from experimental studies suggest that blockade o
Publikováno v:
Mediterranean Journal of Chemistry. 1:232-245
Oxidative stress has been associated in the pathogenesis of numerous diseases such as various neurodegenerative disorders, ischemia, and cancer. The brain is susceptible to oxidative stress due to its high content of peroxidizable unsaturated fatty a
Autor:
Rukhsana Sultana, Jaffer Mohammed, Joshua B. Owen, Tanea T. Reed, Moses Henderson, ReBecca Williams
Publikováno v:
Journal of the Kentucky Academy of Science. 72:105-114
Oxidative stress is associated in the pathogenesis of numerous diseases such as various neurodegenerative disorders, ischemia, and cancer. The brain is susceptible to oxidative stress due to its high level of polyunsaturated fatty acids, increased ra
Autor:
Joshua B. Owen, Michelle A. Erickson, D. Allan Butterfield, Guojun Bu, Tulin O. Price, Christopher D. Aluise, Rukhsana Sultana, William A. Banks
Publikováno v:
Free Radical Biology and Medicine. 49:1798-1803
Alzheimer disease (AD) is a neurodegenerative disorder characterized histopathologically by the presence of senile plaques (SPs), neurofibrillary tangles, and synapse loss. The main component of SPs is amyloid-β peptide (Aβ), which has been associa
Autor:
Joshua B. Owen, D. Allan Butterfield
Publikováno v:
PROTEOMICS - Clinical Applications. 5:50-56
Alzheimer disease (AD) is a neurodegenerative disorder characterized pathologically by the accumulation of senile plaques and neurofibrillary tangles, and both these pathological hallmarks of AD are extensively modified by glycosylation. Mounting evi
Autor:
D. Allan Butterfield, Albena T. Dinkova-Kostova, Vittorio Calabrese, Carolin Cornelius, Joshua B. Owen, Enrico Rizzarelli
Publikováno v:
Antioxidants & redox signalling 11 (2009): 2717–2739. doi:10.1089/ars.2009.2721
info:cnr-pdr/source/autori:Rizzarelli, Enrico (1); Calabrese, Vittorio (1); Butterfield, D. Allan (2); Owen, Joshua B. (2); Cornelius, Carolin (1); Dinkova-Kostova, Albena T. (4)/titolo:Nitric oxide in cell survival: a Janus molecule/doi:10.1089%2Fars.2009.2721/rivista:Antioxidants & redox signalling/anno:2009/pagina_da:2717/pagina_a:2739/intervallo_pagine:2717–2739/volume:11
info:cnr-pdr/source/autori:Rizzarelli, Enrico (1); Calabrese, Vittorio (1); Butterfield, D. Allan (2); Owen, Joshua B. (2); Cornelius, Carolin (1); Dinkova-Kostova, Albena T. (4)/titolo:Nitric oxide in cell survival: a Janus molecule/doi:10.1089%2Fars.2009.2721/rivista:Antioxidants & redox signalling/anno:2009/pagina_da:2717/pagina_a:2739/intervallo_pagine:2717–2739/volume:11
Nitric oxide (NO), plays multiple roles in the nervous system. In addition to regulating proliferation, survival and differentiation of neurons, NO is involved in synaptic activity, neural plasticity, and memory function. Nitric oxide promotes surviv
Autor:
Melissa A. Fleegal-DeMotta, Rukhsana Sultana, William A. Banks, Tulin O. Price, Jessica L. Lynch, Shinya Dohgu, Gul N. Shah, Michelle A. Erickson, D. Allan Butterfiled, Laura B. Jaeger, Joshua B. Owen
Publikováno v:
Brain, Behavior, and Immunity. 23:507-517
Alzheimer's disease (AD) brains are characterized by accumulation of amyloid beta protein (Abeta) and neuroinflammation. Increased blood-to-brain influx and decreased brain-to-blood efflux across the blood-brain barrier (BBB) have been proposed as me
Autor:
Patrick G. Sullivan, Joshua B. Owen, D. Allan Butterfield, Andrea Sebastian, Tanea T. Reed, William M. Pierce
Publikováno v:
Journal of Neuroscience Research. 87:408-417
Traumatic brain injury (TBI) occurs suddenly and has damaging effects to the brain that are dependent on the severity of insult. Symptoms can be mild, moderate, or severe. Oxidative damage is associated with traumatic brain injury through reactive ox
Publikováno v:
Ageing Research Reviews. 8:1-17
The risk of developing neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) increases with age. AD and PD are the two most common neurodegenerative diseases that currently affect millions of persons within the Uni
Autor:
Joshua B, Owen, D Allan, Butterfield
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 648
Glutathione (GSH) is the most abundant antioxidant in aerobic cells, present in micromolar (microM)-concentrations in bodily fluids and in millimolar (mM) concentrations in tissue. GSH is critical for protecting the brain from oxidative stress, actin