Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joshua B Wallach"'
Autor:
Kan Lin, Kathryn M O'Brien, Carolina Trujillo, Ruojun Wang, Joshua B Wallach, Dirk Schnappinger, Sabine Ehrt
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005675 (2016)
Mycobacterium tuberculosis (Mtb) must cope with exogenous oxidative stress imposed by the host. Unlike other antioxidant enzymes, Mtb's thioredoxin reductase TrxB2 has been predicted to be essential not only to fight host defenses but also for in vit
Externí odkaz:
https://doaj.org/article/feb80a1920614d08b6b40b203fd5d2bd
Autor:
Alexandre Gouzy, Gérald Larrouy-Maumus, Daria Bottai, Florence Levillain, Alexia Dumas, Joshua B Wallach, Irène Caire-Brandli, Chantal de Chastellier, Ting-Di Wu, Renaud Poincloux, Roland Brosch, Jean-Luc Guerquin-Kern, Dirk Schnappinger, Luiz Pedro Sório de Carvalho, Yannick Poquet, Olivier Neyrolles
Publikováno v:
PLoS Pathogens, Vol 10, Iss 2, p e1003928 (2014)
Mycobacterium tuberculosis is an intracellular pathogen. Within macrophages, M. tuberculosis thrives in a specialized membrane-bound vacuole, the phagosome, whose pH is slightly acidic, and where access to nutrients is limited. Understanding how the
Externí odkaz:
https://doaj.org/article/ab8fb567ac654e6b8e1dc58688fb2b26
Autor:
Steven J. Grigsby, G.V.R. Krishna Prasad, Joshua B. Wallach, Ekansh Mittal, Fong-Fu Hsu, Dirk Schnappinger, Jennifer A. Philips
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114201- (2024)
Externí odkaz:
https://doaj.org/article/a32504df14934b809f3f49f6039f5fbf
Autor:
Dirk Schnappinger, Rebecca E Audette, Kristine M. Guinn, Michael Fitzgerald, Michelle Gardner, Carolina Trujillo, Joshua Davis, Joshua B. Wallach, Jessica T. Pinkham, Deborah T. Hung, Nirmalya Bandyopadhyay, Mary Stanley, Natalia Betancourt, Christina Gallo, Megan K. Proulx, Jennifer A McConnell, Christopher M. Sassetti, Sofia Kennedy, Elisabeth Meyer, James Gomez, Kayla Delano, Paula A Pino, Emily LaVerriere, K. G. Papavinasasundaram, Eric S. Lander, Eric J. Rubin, Michael H Serrano-Wu, Emma Office, Caitlin E Moss, Naomi Song, Nadine Ruecker, Thomas R. Ioerger, Israel Da Silva, Matthew Thompson, Christopher Watson, Sabine Ehrt, Shoko Wakabayashi, Brian K. Hubbard, Tomohiko Kawate, Kenan C. Murphy, Rebecca Korn, Raymond M. Nietupski, Eachan O. D. Johnson, Aaron Golas
Publikováno v:
Nature. 571:72-78
New antibiotics are needed to combat rising levels of resistance, with new Mycobacterium tuberculosis (Mtb) drugs having the highest priority. However, conventional whole-cell and biochemical antibiotic screens have failed. Here we develop a strategy
Autor:
Curtis A. Engelhart, Nadine Ruecker, Joshua B. Wallach, Jeremy M. Rock, Wenzhu Zhang, Brian T. Chait, Shuqi Li, Anisha Zaveri, Sabine Ehrt, Nicholas C. Poulton, Barbara Bosch, Sophie Lavalette, Michael A. DeJesus, Dirk Schnappinger, Carolina Trujillo
Publikováno v:
Cell
Summary Antibacterial agents target the products of essential genes but rarely achieve complete target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic approaches fails to discern the most attractive bacter
Autor:
Ritu Sharma, Sabine Ehrt, Robert S. Jansen, Joshua B. Wallach, Ruojun Wang, Laure Botella, Anisha Zaveri, Linnan Zhu, Naomi Song, Kyu Y. Rhee, Dirk Schnappinger
Publikováno v:
Molecular Microbiology, 114, 4, pp. 641-652
Molecular Microbiology
Molecular Microbiology, 114, 641-652
Molecular Microbiology
Molecular Microbiology, 114, 641-652
Of the ~80 putative toxin‐antitoxin (TA) modules encoded by the bacterial pathogen Mycobacterium tuberculosis (Mtb), three contain antitoxins essential for bacterial viability. One of these, Rv0060 (DNA ADP‐ribosyl glycohydrolase, DarGMtb), funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c777d164df0a3fca3814a747f6bd67
https://hdl.handle.net/2066/226327
https://hdl.handle.net/2066/226327
Autor:
Sangmi, Oh, Yumi, Park, Curtis A, Engelhart, Joshua B, Wallach, Dirk, Schnappinger, Kriti, Arora, Michelle, Manikkam, Brian, Gac, Hongwu, Wang, Nicholas, Murgolo, David B, Olsen, Michael, Goodwin, Michelle, Sutphin, Danielle M, Weiner, Laura E, Via, Helena I M, Boshoff, Clifton E, Barry
Publikováno v:
Journal of Medicinal Chemistry
Magnesium plays an important role in infection with Mycobacterium tuberculosis ( Mtb) as a signal of the extracellular environment, as a cofactor for many enzymes, and as a structural element in important macromolecules. Raltegravir, an antiretrovira
Autor:
Mary Stanley, Joshua B. Wallach, Michael H Serrano-Wu, Eachan O. D. Johnson, Paula A Pino, Aaron Golas, Rebecca Korn, Naomi Song, Caitlin E Moss, Eric S. Lander, Jessica T. Pinkham, Joshua Davis, Nadine Ruecker, Dirk Schnappinger, Christina Gallo, Tomohiko Kawate, Nirmalya Bandyopadhyay, Deborah T. Hung, Elisabeth Meyer, Michelle Gardner, Jennifer A McConnell, Thomas R. Ioerger, Carolina Trujillo, Megan K. Proulx, Israel Da Silva, Michael Fitzgerald, Kayla Delano, Emma Office, Kristine M. Guinn, Rebecca E Audette, Christopher Watson, K. G. Papavinasasundaram, Eric J. Rubin, Christopher M. Sassetti, Emily LaVerriere, Brian K. Hubbard, Ray Nietupski, Kenan C. Murphy, James Gomez, Matthew Thompson, Sabine Ehrt, Shoko Wakabayashi, Natalia Betancourt
New antibiotics are needed to combat rising resistance, with new Mycobacterium tuberculosis (Mtb) drugs of highest priority. Conventional whole-cell and biochemical antibiotic screens have failed. We developed a novel strategy termed PROSPECT (PRimar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1a1b6871077bae65e4d61671b2b402
Autor:
Mercedes Monteleone, Daniel J. Wilson, Kyu Y. Rhee, Joshua B. Wallach, Dirk Schnappinger, Kathryn O'Brien, Sumit Chakraborty, Ritu Sharma, Jee-Hyun Kim, Clifton E. Barry, Sabine Ehrt, Courtney C. Aldrich, Helena I. Boshoff, German Rehren
Publikováno v:
Proceedings of the National Academy of Sciences. 110:19095-19100
Antibacterial drug development suffers from a paucity of targets whose inhibition kills replicating and nonreplicating bacteria. The latter include phenotypically dormant cells, known as persisters, which are tolerant to many antibiotics and often co
Autor:
Dirk Schnappinger, Richard E. Lee, Joshua B. Wallach, E. Jeffrey North, Andrés Obregón-Henao, Mary Jackson, Wei Li, Mercedes Gonzalez-Juarrero
In recent years, whole-cell-based screens for novel small molecule inhibitors active against Mycobacterium tuberculosis in culture followed by the whole-genome sequencing of spontaneous resistant mutants have identified multiple chemical scaffolds th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1948d73291a48d2823d60552e9f0db0b
https://europepmc.org/articles/PMC4997843/
https://europepmc.org/articles/PMC4997843/