Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joshua B Holmes"'
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 20 (2023)
Background Omecamtiv mecarbil (OM) and danicamtiv both increase myocardial force output by selectively activating myosin within the cardiac sarcomere. Enhanced force generation is presumably due to an increase in the total number of myosin heads boun
Externí odkaz:
https://doaj.org/article/5c2e1e8ef52541f6b9bf787ac3d6ed92
Autor:
Jiayang Li, Ranganath Mamidi, Chang Yoon Doh, Joshua B. Holmes, Nikhil Bharambe, Rajesh Ramachandran, Julian E. Stelzer
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
Decreased cardiac myosin-binding protein C (cMyBPC) expression due to inheritable mutations is thought to contribute to the hypertrophic cardiomyopathy (HCM) phenotype, suggesting that increasing cMyBPC content is of therapeutic benefit. In vitro ass
Externí odkaz:
https://doaj.org/article/f8403e13b7034978baad7fc118ddceba
Autor:
Katherine L. Dominic, Joohee Choi, Joshua B. Holmes, Mandeep Singh, Michael J. Majcher, Julian E. Stelzer
Publikováno v:
Journal of General Physiology. 155
Cardiac myosin binding protein C (cMyBPC) is an 11-domain sarcomeric protein (C0–C10) integral to cardiac muscle regulation. In vitro studies have demonstrated potential functional roles for regions beyond the N-terminus. However, the in vivo contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cde3eee01aec0655597c0faa0eaee5e7
https://doi.org/10.1085/jgp.202213318
https://doi.org/10.1085/jgp.202213318
Publikováno v:
Biophysical Journal. 122:170a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::355009a8c826681f0b4bf012331d5551
https://doi.org/10.1016/j.bpj.2022.11.1066
https://doi.org/10.1016/j.bpj.2022.11.1066
Autor:
Joshua B Holmes, Nikhil Madugula, Ranganath Mamidi, Katherine L Dominic, Chang Yoon Doh, Julian E. Stelzer
Publikováno v:
The Journal of General Physiology
Mamidi et al. investigate the effect of cardiac myosin-binding protein C (cMyBPC) phosphorylation on the response to omecamtiv mecarbil (OM), a candidate heart failure therapy. They show that OM uncouples myocardial force dynamics from cMyBPC phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdc387da64d03df24567301094ba09c
https://doi.org/10.1085/jgp.202012816
https://doi.org/10.1085/jgp.202012816
Autor:
Chang Yoon Doh, Nikhil Bharambe, Joshua B. Holmes, Katherine L. Dominic, Caitlin E. Swanberg, Ranganath Mamidi, Yinghua Chen, Smarajit Bandyopadhyay, Rajesh Ramachandran, Julian E. Stelzer
Publikováno v:
J Struct Biol
INTRODUCTION: The central C4 and C5 domains (C4C5) of cardiac myosin binding protein C (cMyBPC) contain a flexible interdomain linker and a cardiac-isoform specific loop. However, their importance in the functional regulation of cMyBPC has not been e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8573f30c4e8b6bf32b9a3c209b2a8c6
https://doi.org/10.1016/j.jsb.2022.107856
https://doi.org/10.1016/j.jsb.2022.107856
Autor:
Nikhil Bharambe, Joshua B Holmes, Ranganath Mamidi, Jiayang Li, Chang Yoon Doh, Rajesh Ramachandran, Julian E. Stelzer
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
JCI Insight
JCI Insight
Decreased cardiac myosin-binding protein C (cMyBPC) expression due to inheritable mutations is thought to contribute to the hypertrophic cardiomyopathy (HCM) phenotype, suggesting that increasing cMyBPC content is of therapeutic benefit. In vitro ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b02a96ffc49f20b94f34586e1c0ddfc
https://doaj.org/article/f8403e13b7034978baad7fc118ddceba
https://doaj.org/article/f8403e13b7034978baad7fc118ddceba
Prof. Cristobal dos Remedios and the Sydney Heart Bank: enabling translatable heart failure research
Autor:
Joshua B Holmes, Julian E. Stelzer
Publikováno v:
Biophys Rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b983774d92dc3eb98d9639e51b295b2
https://pubmed.ncbi.nlm.nih.gov/32572679
https://pubmed.ncbi.nlm.nih.gov/32572679
Publikováno v:
Expert Opin Drug Discov
INTRODUCTION: Heart failure remains one of the largest clinical challenges in the United States. Researchers have continually searched for more effective heart failure treatments that target the cardiac sarcomere but have found few successes despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057d927c7d3d22a658f8321156756e56
https://europepmc.org/articles/PMC7065952/
https://europepmc.org/articles/PMC7065952/
Publikováno v:
Archives of biochemistry and biophysics. 662
Current inotropic therapies improve systolic function in heart failure patients but they also elicit undesirable side effects such as arrhythmias and increased intracellular Ca(2+) transients. In order to maintain myocyte Ca(2+) homeostasis, the incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff524ac4aa1a01f743360d5c91a40fa
https://pubmed.ncbi.nlm.nih.gov/30576628
https://pubmed.ncbi.nlm.nih.gov/30576628