Zobrazeno 1 - 2
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pro vyhledávání: '"Joshua A.M. Allen"'
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101212- (2022)
Summary: Alternative lengthening of telomeres (ALT) is a homologous recombination-based telomere maintenance mechanism. It is active in approximately 10–15% of cancers. We present a DNA-fiber protocol, combining YOYO-1 staining of genomic DNA, telo
Externí odkaz:
https://doaj.org/article/114fdb9cc6014f9391bc722828359d1f
Autor:
Jonathan Barroso-González, Laura García-Expósito, Pablo Galaviz, Michelle Lee Lynskey, Joshua A.M. Allen, SongMy Hoang, Simon C. Watkins, Hilda A. Pickett, Roderick J. O’Sullivan
Publikováno v:
Cell reports
SUMMARY Alternative lengthening of telomeres (ALT) is a telomere-elongation mechanism observed in ~15% of cancer subtypes. Current models indicate that ALT is mediated by homology-directed repair mechanisms. By disrupting MSH6 gene expression, we sho