Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Joshua A. Weiner"'
Autor:
Yunda Huang, Lily Zhang, Shelly Karuna, Philip Andrew, Michal Juraska, Joshua A. Weiner, Heather Angier, Evgenii Morgan, Yasmin Azzam, Edith Swann, Srilatha Edupuganti, Nyaradzo M. Mgodi, Margaret E. Ackerman, Deborah Donnell, Lucio Gama, Peter L. Anderson, Richard A. Koup, John Hural, Myron S. Cohen, Lawrence Corey, M. Juliana McElrath, Peter B. Gilbert, Maria P. Lemos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Broadly neutralizing monoclonal antibodies (mAbs) are being developed for HIV-1 prevention. Hence, these mAbs and licensed oral pre-exposure prophylaxis (PrEP) (tenofovir-emtricitabine) can be concomitantly administered in clinical trials. I
Externí odkaz:
https://doaj.org/article/1573cc55a90c4367a36a05f7470f768e
Autor:
Kelly E. Seaton, Yunda Huang, Shelly Karuna, Jack R. Heptinstall, Caroline Brackett, Kelvin Chiong, Lily Zhang, Nicole L. Yates, Mark Sampson, Erika Rudnicki, Michal Juraska, Allan C. deCamp, Paul T. Edlefsen, James I. Mullins, Carolyn Williamson, Raabya Rossenkhan, Elena E. Giorgi, Avi Kenny, Heather Angier, April Randhawa, Joshua A. Weiner, Michelle Rojas, Marcella Sarzotti-Kelsoe, Lu Zhang, Sheetal Sawant, Margaret E. Ackerman, Adrian B. McDermott, John R. Mascola, John Hural, M. Julianna McElrath, Philip Andrew, Jose A. Hidalgo, Jesse Clark, Fatima Laher, Catherine Orrell, Ian Frank, Pedro Gonzales, Srilatha Edupuganti, Nyaradzo Mgodi, Lawrence Corey, Lynn Morris, David Montefiori, Myron S. Cohen, Peter B. Gilbert, Georgia D. Tomaras
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104590- (2023)
Summary: Background: The phase 2b proof-of-concept Antibody Mediated Prevention (AMP) trials showed that VRC01, an anti-HIV-1 broadly neutralising antibody (bnAb), prevented acquisition of HIV-1 sensitive to VRC01. To inform future study design and d
Externí odkaz:
https://doaj.org/article/1fb6811de76c4d6b9e00985ef3384be8
Autor:
Harini Natarajan, Shiwei Xu, Andrew R. Crowley, Savannah E. Butler, Joshua A. Weiner, Evan M. Bloch, Kirsten Littlefield, Sarah E. Benner, Ruchee Shrestha, Olivia Ajayi, Wendy Wieland-Alter, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Arturo Casadevall, Andrew Pekosz, Andrew D. Redd, Aaron A. R. Tobian, Ruth I. Connor, Peter F. Wright, Margaret E. Ackerman
Publikováno v:
BMC Immunology, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background While antibodies can provide significant protection from SARS-CoV-2 infection and disease sequelae, the specific attributes of the humoral response that contribute to immunity are incompletely defined. Methods We employ machine le
Externí odkaz:
https://doaj.org/article/034c463115724341925f58490be90688
Autor:
Stacey L. Peek, Peter J. Bosch, Ethan Bahl, Brianna J. Iverson, Mrutyunjaya Parida, Preeti Bais, J. Robert Manak, Jacob J. Michaelson, Robert W. Burgess, Joshua A. Weiner
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103814- (2022)
Summary: Proper gene regulation is critical for both neuronal development and maintenance as the brain matures. We previously demonstrated that Akirin2, an essential nuclear protein that interacts with transcription factors and chromatin remodeling c
Externí odkaz:
https://doaj.org/article/940e5ca7dbf344f6b80be4c28e562945
Autor:
Samir K. Lakhashe, Mario Amacker, Dinesh Hariraju, Hemant K. Vyas, Kyle S. Morrison, Joshua A. Weiner, Margaret E. Ackerman, Vicky Roy, Galit Alter, Guido Ferrari, David C. Montefiori, Georgia D. Tomaras, Sheetal Sawant, Nicole L. Yates, Chris Gast, Sylvain Fleury, Ruth M. Ruprecht
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A virosomal vaccine inducing systemic/mucosal anti-HIV-1 gp41 IgG/IgA had previously protected Chinese-origin rhesus macaques (RMs) against vaginal SHIVSF162P3 challenges. Here, we assessed its efficacy in Indian-origin RMs by intramuscular priming/i
Externí odkaz:
https://doaj.org/article/e308409b63fc452c868c82580e8c0050
Autor:
Harini Natarajan, Andrew R. Crowley, Savannah E. Butler, Shiwei Xu, Joshua A. Weiner, Evan M. Bloch, Kirsten Littlefield, Wendy Wieland-Alter, Ruth I. Connor, Peter F. Wright, Sarah E. Benner, Tania S. Bonny, Oliver Laeyendecker, David Sullivan, Shmuel Shoham, Thomas C. Quinn, H. Benjamin Larman, Arturo Casadevall, Andrew Pekosz, Andrew D. Redd, Aaron A. R. Tobian, Margaret E. Ackerman
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Convalescent plasma has been deployed globally as a treatment for COVID-19, but efficacy has been mixed. Better understanding of the antibody characteristics that may contribute to its antiviral effects is important for this intervention as well as o
Externí odkaz:
https://doaj.org/article/06bc9967a2e644a7be0d758babdbd5ad
Autor:
Savannah E. Butler, Andrew R. Crowley, Harini Natarajan, Shiwei Xu, Joshua A. Weiner, Carly A. Bobak, Daniel E. Mattox, Jiwon Lee, Wendy Wieland-Alter, Ruth I. Connor, Peter F. Wright, Margaret E. Ackerman
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Understanding humoral immune responses to SARS-CoV-2 infection will play a critical role in the development of vaccines and antibody-based interventions. We report systemic and mucosal antibody responses in convalescent individuals who experienced va
Externí odkaz:
https://doaj.org/article/9e96a50019a94152ad25988385639e34
Autor:
Todd Bradley, Justin Pollara, Sampa Santra, Nathan Vandergrift, Srivamshi Pittala, Chris Bailey-Kellogg, Xiaoying Shen, Robert Parks, Derrick Goodman, Amanda Eaton, Harikrishnan Balachandran, Linh V. Mach, Kevin O. Saunders, Joshua A. Weiner, Richard Scearce, Laura L. Sutherland, Sanjay Phogat, Jim Tartaglia, Steven G. Reed, Shiu-Lok Hu, James F. Theis, Abraham Pinter, David C. Montefiori, Thomas B. Kepler, Kristina K. Peachman, Mangala Rao, Nelson L. Michael, Todd J. Suscovich, Galit Alter, Margaret E. Ackerman, M. Anthony Moody, Hua-Xin Liao, Georgia Tomaras, Guido Ferrari, Bette T. Korber, Barton F. Haynes
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
A previous human HIV-1 vaccine clinical trial, boosting with HIV envelope protein from two strains, demonstrated moderate vaccine efficacy. Here, Bradleyet al. show that a pentavalent HIV envelope protein boost improves protection from viral challeng
Externí odkaz:
https://doaj.org/article/c5007d852a844f28b824be4c091a1102
Autor:
Michael J. Molumby, Rachel M. Anderson, Dillan J. Newbold, Norah K. Koblesky, Andrew M. Garrett, Dietmar Schreiner, Jason J. Radley, Joshua A. Weiner
Publikováno v:
Cell Reports, Vol 18, Iss 11, Pp 2702-2714 (2017)
The 22 γ-Protocadherin (γ-Pcdh) cell adhesion molecules are critical for the elaboration of complex dendritic arbors in the cerebral cortex. Here, we provide evidence that the γ-Pcdhs negatively regulate synapse development by inhibiting the posts
Externí odkaz:
https://doaj.org/article/efd28dc1daf948f7a9c622d38a4988a0
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 1037-1050 (2016)
Growth of a properly complex dendrite arbor is a key step in neuronal differentiation and a prerequisite for neural circuit formation. Diverse cell surface molecules, such as the clustered protocadherins (Pcdhs), have long been proposed to regulate c
Externí odkaz:
https://doaj.org/article/5a89a963d28b48a790dc705a53256895