Výsledky vyhledávání - "Joshua A. Stanton"

Akademický článek

High-Dose Acetaminophen Alters the Integrity of the Blood–Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats

Autor: Junzhi Yang, Robert D. Betterton, Erica I. Williams, Joshua A. Stanton, Elizabeth S. Reddell, Chidinma E. Ogbonnaya, Emma Dorn, Thomas P. Davis, Jeffrey J. Lochhead, Patrick T. Ronaldson

Publikováno v: Pharmaceutics, Vol 14, Iss 5, p 949 (2022)

The consumption of acetaminophen (APAP) can induce neurological changes in human subjects; however, effects of APAP on blood–brain barrier (BBB) integrity are unknown. BBB changes by APAP can have profound consequences for brain delivery of co-admi

Externí odkaz: https://doaj.org/article/3bb6e64239064ecc9e872abbd242f14f

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Abstract TP205: Organic Anion Transporting Polypeptides: Endogenous Blood-brain Barrier Transporters That Are Required For Statins To Exert Neuroprotective Effects In Ischemic Stroke

Autor: Erica I Williams, Robert Betterton, Joshua A Stanton, Jeffrey J Lochhead, Thomas P Davis, Patrick T Ronaldson

Publikováno v: Stroke. 54

Clinical development of new drugs for ischemic stroke has been challenging. In contrast, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (i.e., statins) are routinely administered to stroke patients because they improve neurological outcom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dfb50d08e463d5e4a26622596f1fe6d
https://doi.org/10.1161/str.54.suppl_1.tp205

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Targeting Organic Cation Transporters at the Blood-Brain Barrier To Treat Ischemic Stroke in Rats

Autor: Joshua A. Stanton, Erica I. Williams, Robert D. Betterton, Thomas P. Davis, Patrick T. Ronaldson

Publikováno v: Exp Neurol

Drug discovery and development for stroke is challenging as evidenced by few drugs that have advanced beyond a Phase III clinical trial. Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist that has been shown to be neuroprotective in vario

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843b16248b4630917fa3074de498c326
https://europepmc.org/articles/PMC9620710/

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Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 (TGF-β/ALK1) Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors (i.e., Statins)

Autor: Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey L. Lochhead, Hrvoje Brzica, Joshua A Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P Davis, Patrick T. Ronaldson

Publikováno v: Drug Metabolism and Disposition. :DMD-AR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c89e5623867f348dd1ba865910486cb
https://doi.org/10.1124/dmd.121.000781

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