Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joshua A. Kulas"'
Autor:
Lisa A. Post, Joshua A. Kulas, Joshua L. Milstein, Sarah V. L. Sebastian, Seyyedmohsen Hosseini-Barkooie, Max E. Stevenson, George S. Bloom, Heather A. Ferris
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract While historically viewed as an insulin insensitive organ, it is now accepted that insulin has a role in brain physiology. Changes in brain insulin and IGF1 signaling have been associated with neurological diseases, however the molecular fac
Externí odkaz:
https://doaj.org/article/f1aaef2f449c46ba99d160a3b2b7f049
Autor:
Hao Wang, Joshua A. Kulas, Holden Higginbotham, Michael A. Kovacs, Heather A. Ferris, Scott B. Hansen
Neurodegeneration and its concomitant loss of cognitive function is associated with inflammation and an accumulation of lipids, in particular cholesterol. In the brain, cholesterol is made in astrocytes and transported to surrounding cells by apolipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b75452935230c630304b91984e7242c4
https://doi.org/10.1101/2022.12.12.520161
https://doi.org/10.1101/2022.12.12.520161
Publikováno v:
Drug Dev Res
Diabetes disrupts organs throughout the body including the brain. Evidence suggests diabetes is a risk factor for Alzheimer's disease (AD) and neurodegeneration. In this review, we focus on understanding how diabetes contributes to the progression of
Autor:
Hannah Ennerfelt, Elizabeth L. Frost, Daniel A. Shapiro, Coco Holliday, Kristine E. Zengeler, Gabrielle Voithofer, Ashley C. Bolte, Catherine R. Lammert, Joshua A. Kulas, Tyler K. Ulland, John R. Lukens
Publikováno v:
Cell. 185:4135-4152.e22
Recent studies have begun to reveal critical roles for the brain's professional phagocytes, microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin debris accumulation in neurodegenerative disease. However, the criti
Autor:
Pinar Pezuk, Lei Liu, Petr Tvrdik, Heather A. Ferris, Joshua A. Kulas, J. Javier Provencio, William Gartman, Paul Varghese, Aminata P. Coulibaly, Mariam Syed, Danielle Triebwasser
Publikováno v:
Stroke
Background and Purpose: Aneurysmal subarachnoid hemorrhage (SAH) is associated with the development of delayed cognitive deficits. Neutrophil infiltration into the central nervous system is linked to the development of these deficits after SAH. It is
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The accumulation of amyloid β (Aβ) in the brain appears to be a necessary event in the pathogenesis of Alzheimer’s disease (AD). However, processes linked to the endogenous regulation of Aβ production are still not completely unders
Autor:
Joshua A. Kulas, Matthew W. Gorr, Kendra L. Puig, Michael P. McDonald, Colin K. Combs, Justine E. Melvin, Jordan V. Hettwer, Vineeta Tanwar, Loren E. Wold, Mona Sohrabi, Gunjan D. Manocha
Publikováno v:
Environmental Pollution. 241:279-288
Environmental exposure to air pollution has been linked to a number of health problems including organ rejection, lung damage and inflammation. While the deleterious effects of air pollution in adult animals are well documented, the long-term consequ
Publikováno v:
Alzheimer's & Dementia. 16
Alzheimer’s Disease (AD) is characterized by the presence of β-Amyloid (Aβ) plaques, tau tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol transport protein, apolipoprotein E (apoE), is the most common gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d07cb40ed30605cfdec3a4681e84b4
https://doi.org/10.1101/2020.06.18.159632
https://doi.org/10.1101/2020.06.18.159632
Autor:
Aminata P. Coulibaly, Pinar Pezuk, Paul Varghese, William Gartman, Danielle Triebwasser, Joshua A. Kulas, Lei Liu, Mariam Syed, Petr Tvrdik, Heather A Ferris, Jose Javier Provencio
Background: Aneurysmal subarachnoid hemorrhage (SAH) is associated with the development of delayed cognitive deficits. Neutrophil infiltration into the central nervous system (CNS) is linked to the development of these deficits after SAH. It is howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f455545db220e8713725180644da478f
https://doi.org/10.21203/rs.2.22087/v2
https://doi.org/10.21203/rs.2.22087/v2