Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Joshua A. Kritzer"'
Autor:
Hawley Brown, Mia Chung, Alina Üffing, Nefeli Batistatou, Tiffany Tsang, Samantha Doskocil, Weiqun Mao, Dieter Willbold, Robert C. Bast, Zhen Lu, Oliver H. Weiergräber, Joshua A. Kritzer
Publikováno v:
Journal of the American Chemical Society. 144(32)
The LC3/GABARAP family of proteins is involved in nearly every stage of autophagy. Inhibition of LC3/GABARAP proteins is a promising approach to blocking autophagy, which sensitizes advanced cancers to DNA-damaging chemotherapy. Here, we report the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b685cdf42a6130c53d361150a69e6eb5
https://pubmed.ncbi.nlm.nih.gov/35917476
https://pubmed.ncbi.nlm.nih.gov/35917476
Autor:
Nefeli Batistatou, Joshua A. Kritzer
Publikováno v:
ChemBioChem. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76336835b1d1e9ff1b6d89e43bb78362
https://doi.org/10.1002/cbic.202300009
https://doi.org/10.1002/cbic.202300009
Autor:
Charles Abakah, Jiayuan Miao, Kirsten Deprey, James D. Baleja, Adam Moyer, Bryan J. Lampkin, Jennifer R. Pace, David Baker, Yu-Shan Lin, Joshua A. Kritzer, Robert A. Cerulli
Publikováno v:
J Am Chem Soc
Peptides constrained by intramolecular cross-links, especially stapled α-helices, have emerged as versatile scaffolds for drug development. However, there are fewer examples of similarly constrained scaffolds for other secondary structures. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b2db5b75ccf8e6895ff17249aed574
https://doi.org/10.1021/jacs.1c04378
https://doi.org/10.1021/jacs.1c04378
Publikováno v:
ACS Chem Biol
The efficiency with which polycationic peptides penetrate the cytosol depends on the number and overall patterning of arginine residues. While general trends and unusually penetrant patterns of arginine residues have been discovered, prior work has n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c999046ac96a6bc2bcd9bc45d4ed77b
https://doi.org/10.1021/acschembio.1c00434
https://doi.org/10.1021/acschembio.1c00434
Publikováno v:
Nucleic Acids Research
RNA therapeutics are a promising strategy to treat genetic diseases caused by the overexpression or aberrant splicing of a specific protein. The field has seen major strides in the clinical efficacy of this class of molecules, largely due to chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155b472acc5745a6ecbe3df8ec92b162
https://doi.org/10.1093/nar/gkaa576
https://doi.org/10.1093/nar/gkaa576
Autor:
Joshua A. Kritzer, Jennifer R. Pace, Hawley F. Brown, Robert A. Cerulli, Livia Shehaj, Yang Mei
Publikováno v:
Chembiochem
A growing body of evidence suggests that autophagy inhibition enhances the effectiveness of chemotherapy, especially in difficult-to-treat cancers. Existing autophagy inhibitors are primarily lysosomotropic agents. More specific autophagy inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b068ef6b388b98a96f0180d799b05a7
https://doi.org/10.1002/cbic.202000212
https://doi.org/10.1002/cbic.202000212
Autor:
Joshua A. Kritzer, Robert A. Cerulli
Publikováno v:
Org Biomol Chem
Tyrosine phosphorylation is a critical component of signal transduction for multicellular organisms, particularly for pathways that regulate cell proliferation and differentiation. While tyrosine kinase inhibitors have become FDA-approved drugs, inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c281efbe62bf3ecbe5ca3165cf270c8f
https://doi.org/10.1039/c9ob01998g
https://doi.org/10.1039/c9ob01998g
Autor:
Kirsten Deprey, Nefeli Batistatou, Marjoke F. Debets, Jack Godfrey, Kirstin B. VanderWall, Rebecca R. Miles, Livia Shehaj, Jiaxing Guo, Amy Andreucci, Pachamuthu Kandasamy, Genliang Lu, Mamoru Shimizu, Chandra Vargeese, Joshua A. Kritzer
Publikováno v:
ACS Chem Biol
A major obstacle to the development of effective oligonucleotide therapeutics is a lack of understanding about their cytosolic and nuclear penetration. To address this problem, we have applied the chloroalkane penetration assay (CAPA) to oligonucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca7a1a52699e0b7e5fa1b2efc41faf6
https://europepmc.org/articles/PMC9252293/
https://europepmc.org/articles/PMC9252293/
Autor:
Seth T. Gammon, Jing Wang, Hailing Yang, Philip Rask, Robert C. Bast, Margie N. Sutton, Joshua A. Kritzer, David Piwnica-Worms, Zhen Lu, Brian J. Engel, Joshua P. Gray, Nasir Uddin, Brian J. Grindel, Shuxing Zhang, Hannah Locke, Pratip K. Bhattacharya, Nefeli Batistatou, Rajan Chaudhari, Steven W. Millward
Publikováno v:
Chemical Science
In recent decades it has become increasingly clear that induction of autophagy plays an important role in the development of treatment resistance and dormancy in many cancer types. Unfortunately, chloroquine (CQ) and hydroxychloroquine (HCQ), two aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6732414080b780a1ff6f24a692e7df73
https://pubmed.ncbi.nlm.nih.gov/34163626
https://pubmed.ncbi.nlm.nih.gov/34163626
Autor:
Joshua A. Kritzer, Yu-Shan Lin, Jiayuan Miao, Diana P. Slough, Sean M. McHugh, Ashleigh E. Cummings
Publikováno v:
Biophysical Journal. 116:433-444
Cyclic peptides (CPs) are a promising class of molecules for drug development, particularly as inhibitors of protein-protein interactions. Predicting low-energy structures and global structural ensembles of individual CPs is critical for the design o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db5dde085dd8d7db7000911bf9e0da4
https://doi.org/10.1016/j.bpj.2018.12.015
https://doi.org/10.1016/j.bpj.2018.12.015