Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joshua A. Kochanowsky"'
Autor:
Sambamurthy Chandrasekaran, Joshua A. Kochanowsky, Emily F. Merritt, Joseph S. Lagas, Ayesha Swannigan, Anita A. Koshy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Toxoplasma gondii can persist in neurons in the central nervous system, presumably because neurons have limited cell-intrinsic immune responses. However, here, Chandrasekaran et al. show that IFN-gamma stimulated primary murine neurons can clear T. g
Externí odkaz:
https://doaj.org/article/c3f6c19a5c644d84b8b2bfff6d5d14ec
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Toxoplasma gondii
Externí odkaz:
https://doaj.org/article/b2b8e876d867408ab5d33f797aa8ef26
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0300764 (2024)
Toxoplasma gondii is an intracellular parasite that establishes a long-term infection in the brain of many warm-blooded hosts, including humans and rodents. Like all obligate intracellular microbes, Toxoplasma uses many effector proteins to manipulat
Externí odkaz:
https://doaj.org/article/b4ba03fe41214b48bebf275278e87443
Autor:
Joshua A Kochanowsky, Sambamurthy Chandrasekaran, Jacqueline R Sanchez, Kaitlin K Thomas, Anita A Koshy
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011347 (2023)
Toxoplasma gondii establishes a long-lived latent infection in the central nervous system (CNS) of its hosts. Reactivation in immunocompromised individuals can lead to life threatening disease. Latent infection is driven by the ability of the parasit
Externí odkaz:
https://doaj.org/article/5559e21db46c4a9fa2913b50cf05d85c
Autor:
Shraddha Tuladhar, Joshua A Kochanowsky, Apoorva Bhaskara, Yarah Ghotmi, Sambamurthy Chandrasekaran, Anita A Koshy
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1007856 (2019)
Toxoplasma gondii is an intracellular parasite that persistently infects the CNS and that has genetically distinct strains which provoke different acute immune responses. How differences in the acute immune response affect the CNS immune response is
Externí odkaz:
https://doaj.org/article/ba0de56f6ca84c8ea5692fc8ed9b07e2
Autor:
Joshua A. Kochanowsky, Sambamurthy Chandrasekaran, Jacqueline R. Sanchez, Kaitlin K. Thomas, Anita A. Koshy
Toxoplasma gondiiestablishes a long-lived latent infection in the central nervous system (CNS) of its hosts. Reactivation in immunocompromised individuals can lead to life threatening disease. Latent infection is driven by the ability of the parasite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b507de882286ac8044ef68e89ba4947a
https://doi.org/10.1101/2022.07.31.502204
https://doi.org/10.1101/2022.07.31.502204
Autor:
Sambamurthy Chandrasekaran, Joshua A. Kochanowsky, Emily F. Merritt, Joseph S. Lagas, Ayesha Swannigan, Anita A. Koshy
SummaryDogma holds thatToxoplasma gondiipersists in neurons because neurons cannot clear intracellular parasites, even with IFN-γ stimulation. As several recent studies questioned this idea, we used primary murine neuronal cultures from wild-type an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85fb1e1da567c3613e8e5d86f3a35380
https://doi.org/10.1101/2021.11.10.468098
https://doi.org/10.1101/2021.11.10.468098
Autor:
Joshua A. Kochanowsky, Anita A. Koshy
Publikováno v:
Cell. 180:216-218
Microbes that cause persistent infections (e.g., herpes viruses) do so by switching from fast-growing lytic states to slow-growing latent states. Waldman et al. have identified a single transcription factor that governs the switch between the lytic a
Autor:
Corbett T. Berry, Anthony T. Phan, Longfei Chen, Christopher A. Hunter, Xiaoguang Chen, Shuai Wang, Joshua A. Kochanowsky, Jung Oh, David A. Christian, Daniel P. Beiting, Anita A. Koshy, Joseph T. Clark, David S. Roos
Publikováno v:
The Journal of Experimental Medicine
Toxoplasma gondii ROP16 is a virulence factor that modulates immune reposes acting in cis and in trans.
The protozoan pathogen Toxoplasma gondii co-opts host immunity by secreting various effector proteins into host cells. In this issue of JEM,
The protozoan pathogen Toxoplasma gondii co-opts host immunity by secreting various effector proteins into host cells. In this issue of JEM,
Autor:
Apoorva Bhaskara, Joshua A. Kochanowsky, Sambamurthy Chandrasekaran, Anita A. Koshy, Shraddha Tuladhar, Yarah Ghotmi
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1007856 (2019)
PLoS Pathogens
PLoS Pathogens
Toxoplasma gondii is an intracellular parasite that persistently infects the CNS and that has genetically distinct strains which provoke different acute immune responses. How differences in the acute immune response affect the CNS immune response is