Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Joshua A. Hackney"'
Autor:
JoAnne L. Flynn, Patricia A. Darrah, Phillip A. Swanson, Nicole L. Grant, Pauline Maiello, Chelsea M Causgrove, Travis K. Hughes, Danilo R. Casimiro, Megha Kamath, Joseph J. Zeppa, Edwin Klein, Supriya Pokkali, Alexander G. White, Mario Roederer, Philana Ling Lin, Joshua A Hackney, Aurelio Bonavia, Charles A. Scanga, Marc H. Wadsworth, Alex K. Shalek, Robert A. Seder, Dominick Laddy, Mark Rodgers
Publikováno v:
Nature. 577:95-102
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette–Guerin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause o
Autor:
Patricia A. Darrah, Joseph J. Zeppa, Chuangqi Wang, Edward B. Irvine, Allison N. Bucsan, Mark A. Rodgers, Supriya Pokkali, Joshua A. Hackney, Megha Kamath, Alexander G. White, H. Jacob Borish, L. James Frye, Jaime Tomko, Kara Kracinovsky, Philana L. Lin, Edwin Klein, Charles A. Scanga, Galit Alter, Sarah M. Fortune, Douglas A. Lauffenburger, JoAnne L. Flynn, Robert A. Seder, Pauline Maiello, Mario Roederer
Publikováno v:
SSRN Electronic Journal.
Autor:
Willie J. Swanson, Krystle K. Q. Yu, Charlotte A. James, Patricia A. Darrah, Malisa T. Smith, Chetan Seshadri, Mario Roederer, Joshua A Hackney, Kathryn E. Foulds, Lichen Jing, Damien B. Wilburn, Robert A. Seder, David M. Koelle
Publikováno v:
Immunogenetics
Invariant NKT (iNKT) cells in both humans and non-human primates are activated by the glycolipid antigen, α-galactosylceramide (α-GalCer). However, the extent to which the molecular mechanisms of antigen recognition and in vivo phenotypes of iNKT c
Autor:
Charles A. Scanga, Mario Roederer, JoAnne L. Flynn, Mark Rodgers, Pauline Maiello, Joshua A Hackney, Thomas Lindenstrøm, Amy J. Myers, Victor Prikhodko, Dominick Laddy, Hannah P. Gideon, Patricia A. Darrah, Philana Ling Lin, Robert M. DiFazio, Peter Andersen, Thomas J. Evans, Robert A. Seder
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-13 (2019)
NPJ Vaccines
NPJ Vaccines
Tuberculosis (TB) is the leading cause of death from infection worldwide. The only approved vaccine, BCG, has variable protective efficacy against pulmonary TB, the transmissible form of the disease. Therefore, improving this efficacy is an urgent pr
Autor:
Joseph John Zeppa, Patricia A Darrah, Supriya Pokkali, Joshua A Hackney, Pauline A Maiello, Charles A. Scanga, Dominick J Laddy, Philiana Ling Lin, Robert A Seder, Mario Roederer, JoAnne L Flynn
Publikováno v:
The Journal of Immunology. 202:139.3-139.3
Our laboratory has demonstrated that intravenous (IV) vaccination with Bacille Calmette-Guerin (BCG; 5x107CFU) provides remarkably robust protection against low-dose Mycobacterium tuberculosis (Mtb) infection in Rhesus macaques (9/10 animals protecte