Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Joshua A. Bueller"'
Autor:
Jennifer S. Labus, Jean Stains, Brandall Y. Suyenobu, M. Mandelkern, Arpana Gupta, Joshua A. Bueller, Heng Wong, Kirsten Tillisch, Emeran A. Mayer, Leah FitzGerald, Gordon V. Ohning, Bruce D. Naliboff, Steven M. Berman
Publikováno v:
NeuroImage. 63:1854-1863
Alterations in noradrenergic (NE) signaling have been implicated in the pathophysiology of irritable bowel syndrome (IBS), and adrenergic receptors are potential treatment targets.To characterize central NE signaling in IBS, 11 patients and 11 health
Autor:
Emeran A. Mayer, J. McKelvy, B. Nam, Kirsten Tillisch, Joao Siffert, Jennifer S. Labus, Bruce D. Naliboff, Suzanne R. Smith, Brandall Y. Suyenobu, Joshua A. Bueller
Publikováno v:
Alimentary Pharmacology & Therapeutics. 35:360-367
Summary Background Irritable bowel syndrome is characterised by chronic abdominal pain and frequent comorbid anxiety. The substance P/neurokinin-1 receptor system is implicated in the regulation of both pain and anxiety, suggesting a potential therap
Autor:
Jennifer S. Labus, George E. Dukes, Kirsten Tillisch, Emeran A. Mayer, Dennis Kelleher, Jean Stains, Bruce D. Naliboff, Brandall Y. Suyenobu, Catherine S. Hubbard, Joshua A. Bueller
Publikováno v:
The Journal of Neuroscience. 31:12491-12500
Alterations in corticotropin-releasing factor (CRF) signaling pathways have been implicated in irritable bowel syndrome (IBS) pathophysiology. We aimed to (1) determine the effect of the selective CRF receptor 1 antagonist (CRF1) GW876008 relative to
Autor:
Jennifer S. Labus, Bruce D. Naliboff, Steve M. Berman, Joshua A. Bueller, Emeran A. Mayer, Brandall Y. Suyenobu, M. Mandelkern, James H. Fallon
Publikováno v:
NeuroImage. 41:1032-1043
Differences in brain responses to aversive visceral stimuli may underlie previously reported sex differences in symptoms as well as perceptual and emotional responses to such stimuli in patients with Irritable Bowel Syndrome (IBS). The goal of the cu
Autor:
Jennifer S. Labus, Emeran A. Mayer, Bruce D. Naliboff, Joshua A. Bueller, Kim Ruby, Brandall Y. Suyenobu, Gordon V. Ohning, Lisa A. Kilpatrick, Johanna M. Jarcho, Jean Stains, Steven M. Berman
Publikováno v:
The Journal of Neuroscience. 28:349-359
Cognitive factors such as fear of pain and symptom-related anxiety play an important role in chronic pain states. The current study sought to characterize abnormalities in preparatory brain response before aversive pelvic visceral distention in irrit
Autor:
Lorraine M. Fig, Jennifer C. Britton, K. Luan Phan, Joshua A. Bueller, Robert A. Koeppe, Israel Liberzon, Stephan F. Taylor, Jon Kar Zubieta
Publikováno v:
Biological Psychiatry. 61:1030-1038
Background Functional neuroimaging studies have detected abnormal limbic and paralimbic activation to emotional probes in posttraumatic stress disorder (PTSD), but few studies have examined neurochemical mechanisms that underlie functional alteration
Autor:
Mark K. Greenwald, Robert A. Koeppe, Yan Chang, Chris Ellyn Johanson, Joshua A. Bueller, Jon Kar Zubieta, Michael R. Kilbourn, David E. Moody
Publikováno v:
Biological Psychiatry. 61:101-110
Background Buprenorphine (BUP) is effective in the treatment of opioid dependence when given on alternating days, probably as a result of long-lasting occupation of μ opioid receptors (μORs). This study examined the duration of action of BUP at μO
Autor:
Jean Stains, Steven M. Berman, Jennifer S. Labus, Brandall Y. Suyenobu, Emeran A. Mayer, Kim Ruby, Joshua A. Bueller, Bruce D. Naliboff
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 291:R268-R276
To explore sex differences in the response of seven brain regions to an aversive pelvic visceral stimulus, functional magnetic resonance images were acquired from 13 healthy adults (6 women) during 15 s of cued rectal distension at two pressures: 25
Autor:
Yolanda R. Smith, Robert A. Koeppe, Christian S. Stohler, Yanjun Xu, Joshua A. Bueller, Ke Xu, Jon Kar Zubieta, David Goldman, Mary M. Heitzeg
Publikováno v:
Science. 299:1240-1243
Responses to pain and other stressors are regulated by interactions between multiple brain areas and neurochemical systems. We examined the influence of a common functional genetic polymorphism affecting the metabolism of catecholamines on the modula
Autor:
Yolanda R. Smith, Charles R. Meyer, Yanjun Xu, Joshua A. Bueller, Douglas M. Jewett, Jon Kar Zubieta, Robert A. Koeppe, Christian S. Stohler, Michael R. Kilbourn
Publikováno v:
The Journal of Neuroscience. 22:5100-5107
Sex differences in the experience of clinical and experimental pain have been reported. However, the neurobiological sources underlying the variability in pain responses between sexes have not been adequately explored, especially in humans. The endog