Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Joshua A. Bittker"'
Autor:
Willmen Youngsaye, Cathy L. Hartland, Barbara J. Morgan, Amal Ting, Partha P. Nag, Benjamin Vincent, Carrie A. Mosher, Joshua A. Bittker, Sivaraman Dandapani, Michelle Palmer, Luke Whitesell, Susan Lindquist, Stuart L. Schreiber, Benito Munoz
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 1501-1507 (2013)
The National Institutes of Health Molecular Libraries and Probe Production Centers Network (NIH-MLPCN) screened >300,000 compounds to evaluate their ability to restore fluconazole susceptibility in resistant Candida albicans isolates. Additional coun
Externí odkaz:
https://doaj.org/article/c0c9f1b39d1f4f6ea80ec4345fe19ee4
Autor:
Stuart L. Schreiber, Paul A. Clemons, Alykhan F. Shamji, James E. Bradner, Michelle Palmer, Joshua A. Bittker, Vlado Dančík, Ted Liefeld, Benito Munoz, C. Suk-Yee Hon, Joanne D. Kotz, Nurdan Kuru, Mathias J. Wawer, Philip Montgomery, Ava Li, Benjamin Alexander, Joshua Gould, Christian K. Soule, Nicole E. Bodycombe, Victor Jones, Matthew E. Coletti, Edmund V. Price, Murat Cokol, Jaime H. Cheah, Matthew G. Rees, Brinton Seashore-Ludlow
Supplementary figure legends. Supplementary methods, including additional filtering and heuristics for sensitivity data processing and ACME analysis and additional methods for western blotting and immunostaining. Supplementary Table S8. Small molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c61698389d706f3e5ca7dcc783115de
https://doi.org/10.1158/2159-8290.22530798
https://doi.org/10.1158/2159-8290.22530798
Autor:
Stuart L. Schreiber, Paul A. Clemons, Alykhan F. Shamji, James E. Bradner, Michelle Palmer, Joshua A. Bittker, Vlado Dančík, Ted Liefeld, Benito Munoz, C. Suk-Yee Hon, Joanne D. Kotz, Nurdan Kuru, Mathias J. Wawer, Philip Montgomery, Ava Li, Benjamin Alexander, Joshua Gould, Christian K. Soule, Nicole E. Bodycombe, Victor Jones, Matthew E. Coletti, Edmund V. Price, Murat Cokol, Jaime H. Cheah, Matthew G. Rees, Brinton Seashore-Ludlow
Supplemental Table S1. Small-molecule Informer Set Description of the small-molecule informer set used in the sensitivity profiling experiment, including protein target or activity. Supplemental Table S2.Cancer cell-line panel Description of the canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330bf15e5f4c577c9f7b2b4ddfd54d5e
https://doi.org/10.1158/2159-8290.22530801
https://doi.org/10.1158/2159-8290.22530801
Autor:
Stuart L. Schreiber, Paul A. Clemons, Alykhan F. Shamji, James E. Bradner, Michelle Palmer, Joshua A. Bittker, Vlado Dančík, Ted Liefeld, Benito Munoz, C. Suk-Yee Hon, Joanne D. Kotz, Nurdan Kuru, Mathias J. Wawer, Philip Montgomery, Ava Li, Benjamin Alexander, Joshua Gould, Christian K. Soule, Nicole E. Bodycombe, Victor Jones, Matthew E. Coletti, Edmund V. Price, Murat Cokol, Jaime H. Cheah, Matthew G. Rees, Brinton Seashore-Ludlow
Supplemental Figure S1. Further characterization of the small-molecule Informer Set and comparisons between CTRP v1 and v2. Supplemental Figure S2. Cellular features of the CCL panel. Supplemental Figure S3. Details on ACME analysis described in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad4befd455ce48a1c76862d653553c1
https://doi.org/10.1158/2159-8290.22530792.v1
https://doi.org/10.1158/2159-8290.22530792.v1
Autor:
Ryan O’Rourke, Aaron R. Thorner, Francisca Vazquez, Nicholas J. Lyons, Aviad Tsherniak, Peter Tsvetkov, Helen Tang, Anthony J. Garrity, Gavin Ha, Chet Birger, Guillaume Kugener, Craig A. Strathdee, Rameen Beroukhim, Robert Burns, Bang Wong, Pratiti Bandopadhayay, Anwesha Nag, Benjamin A. Siranosian, Andrew A. Tubelli, Todd R. Golub, Mahmoud Ghandi, Matthew Meyerson, Yosef E. Maruvka, Joshua A. Bittker, Joshua M. Dempster, Kunihiko Hinohara, Uri Ben-David, Beth A. Cimini, Yaara Oren, Gad Getz
Publikováno v:
Bulletin du Cancer
Bulletin du Cancer, John Libbey Eurotext, 2019, 106 (1), pp.9-10. ⟨10.1016/j.bulcan.2018.12.002⟩
Nature
Bulletin du Cancer, John Libbey Eurotext, 2019, 106 (1), pp.9-10. ⟨10.1016/j.bulcan.2018.12.002⟩
Nature
The extent of genetic and epigenetic diversity between and within patient tumors is being mapped in ever more detail. It is clear that cancer is an evolutionary process in which tumor cell intrinsic and extrinsic forces shape clonal selection. The pr
Autor:
Eamon Comer, Joshua B. Radke, Herbert W. Virgin, L. David Sibley, Kimberly L. Carey, Stuart L. Schreiber, Jose Perez, Carol Mulrooney, Shailesh Metkar, Robert Hilgraf, Subrata Shaw, Jennifer P. Gale, Joshua A. Bittker
Publikováno v:
ACS Infectious Diseases. 4:1499-1507
Toxoplasma gondii is an obligate intracellular parasite capable of causing severe disease due to congenital infection and in patients with compromised immune systems. Control of infection is dependent on a robust Th1 type immune response including pr
Autor:
Yongjie Wei, José Carlos Rodríguez Pérez, Jenna B. Yehl, Matthew J. Ranaghan, Beth Levine, Zhongju Zou, Bruce A. Posner, Yi Chun Kuo, Adam Skepner, Shuguang Wei, Joshua A. Bittker, Wei Chung Chiang, Anwu Zhou
Publikováno v:
ACS Chemical Biology. 13:2247-2260
Autophagy, a lysosomal degradation pathway, plays a crucial role in cellular homeostasis, development, immunity, tumor suppression, metabolism, prevention of neurodegeneration, and lifespan extension. Thus, pharmacological stimulation of autophagy ma
Autor:
Wenye Sun, Zhenmin He, Adel M. Naylor-Olsen, Deming Xu, Joseph P. Vacca, Leanne Bedard, Ashlee M. Earl, Christina Scherer, Abigail L. Manson, Maurice D. Lee, Diane M Rush, Mark E. Fitzgerald, Mingliang Zhang, Huisheng Xu, Michelle Palmer, Joshua A. Bittker, Michael Foley, Jean-Charles Marie, Jeremy R. Duvall, Giovanni Muncipinto
Publikováno v:
ACS Infectious Diseases. 3:349-359
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options current
Autor:
David H. Sherr, Stefano Monti, Amy Li, Xiaodong Lu, Nisha S. Sipes, Scott S. Auerbach, Aravind Subramanian, Ted Natoli, Joshua A. Bittker
Publikováno v:
Environmental Health Perspectives
Background: Most chemicals in commerce have not been evaluated for their carcinogenic potential. The de facto gold-standard approach to carcinogen testing adopts the 2-y rodent bioassay, a time-consuming and costly procedure. High-throughput in vitro
Autor:
Daniel E. Neafsey, Dyann F. Wirth, Jon Clardy, Arvind Sharma, Ping S. Lui, Anne-Marie Zeeman, Sean Eckley, Yvonne Van Gessel, Mathias Wawer, Matthias Marti, Elizabeth A. Winzeler, Elamaran Meibalan, Nobutaka Kato, Benito Munoz, Emily R. Derbyshire, Stuart L. Schreiber, Marshall L. Morningstar, Jeremy R. Duvall, Clemens H. M. Kocken, Eli L. Moss, Bennett C. Meier, Joshua A. Bittker, Vicky M. Avery, Manmohan Sharma, John E. Burke, Eamon Comer, Jacob A. McPhail, Maurice A. Itoe, Jessica Bastien, Nicolas M. B. Brancucci, Branko Mitasev, David Clarke, Timothy A. Lewis, Victoria C. Corey, Sandra Duffy, Tomoyo Sakata-Kato, Fabian Gusovsky, Sandra March, Takashi Yoshinaga, Gillian L. Dornan, Flaminia Catteruccia, Morgane Sayes, Emily Lund, Christina Scherer, Sangeeta N. Bhatia, Michael Foley, Amit Sharma, Amanda K. Lukens, Paul A. Clemons, Koen J. Dechering, Karin M. J. Koolen, Micah Maetani
Publikováno v:
Nature
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of action could be discovered using a diverse collection