Zobrazeno 1 - 10
of 835
pro vyhledávání: '"Joshua A Young"'
Autor:
Greta Bigelyte, Joshua K. Young, Tautvydas Karvelis, Karolina Budre, Rimante Zedaveinyte, Vesna Djukanovic, Elizabeth Van Ginkel, Sushmitha Paulraj, Stephen Gasior, Spencer Jones, Lanie Feigenbutz, Grace St. Clair, Pierluigi Barone, Jennifer Bohn, Ananta Acharya, Gina Zastrow-Hayes, Selgar Henkel-Heinecke, Arunas Silanskas, Ralf Seidel, Virginijus Siksnys
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Miniature Cas12f editing systems are well suited for in vivo editing applications. Here the authors characterize the intrinsic activity of SpCas12f1 in plant and animal cells.
Externí odkaz:
https://doaj.org/article/688a63ea2c9f45e084a40d762048f444
Autor:
Giedrius Gasiunas, Joshua K. Young, Tautvydas Karvelis, Darius Kazlauskas, Tomas Urbaitis, Monika Jasnauskaite, Mantvyda M. Grusyte, Sushmitha Paulraj, Po-Hao Wang, Zhenglin Hou, Shane K. Dooley, Mark Cigan, Clara Alarcon, N. Doane Chilcoat, Greta Bigelyte, Jennifer L. Curcuru, Megumu Mabuchi, Zhiyi Sun, Ryan T. Fuchs, Ezra Schildkraut, Peter R. Weigele, William E. Jack, G. Brett Robb, Česlovas Venclovas, Virginijus Siksnys
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
A few bacterial Cas9 nucleases have been repurposed as genome editing tools. Here, the authors use bioinformatic and biochemical analyses to characterize 79 Cas9 proteins, revealing substantial functional diversity and thus expanding the available to
Externí odkaz:
https://doaj.org/article/eff8b92a7b8248269794dd870fd5600c
Autor:
Elvira O. Gosmanova, Olulade Ayodele, Kristina Chen, Erin E. Cook, Fan Mu, Joshua A. Young, Lars Rejnmark
Publikováno v:
International Journal of Endocrinology, Vol 2022 (2022)
Objective. Reasons for the increased incidence of chronic kidney disease (CKD) in patients with chronic hypoparathyroidism are poorly understood. This study evaluated associations between levels of albumin-corrected serum calcium, serum phosphate, an
Externí odkaz:
https://doaj.org/article/8e1de5ddc3df44e7accf2acf70e17748
Autor:
Huirong Gao, Jasdeep Mutti, Joshua K. Young, Meizhu Yang, Megan Schroder, Brian Lenderts, Lijuan Wang, Dave Peterson, Grace St. Clair, Spencer Jones, Lanie Feigenbutz, Wally Marsh, Min Zeng, Susan Wagner, Jeffry Farrell, Kay Snopek, Chris Scelonge, Xiaoyi Sopko, Jeffry D. Sander, Scott Betts, A. Mark Cigan, N. Doane Chilcoat
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
Modern maize hybrids often contain biotech and native traits. To-date all biotech traits have been randomly inserted in the genome. Consequently, developing hybrids with multiple traits is expensive, time-consuming, and complex. Here we report using
Externí odkaz:
https://doaj.org/article/1e57717eb81b4cd696863de608e3ba39
Autor:
Donna Carstens, Diego J. Maselli, Fan Mu, Erin E. Cook, Danni Yang, Joshua A. Young, Keith A. Betts, Eduardo Genofre, Yen Chung
Publikováno v:
The Journal of Allergy and Clinical Immunology: In Practice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dda9957053d19282e6a9a80f4210591
https://doi.org/10.1016/j.jaip.2023.04.029
https://doi.org/10.1016/j.jaip.2023.04.029
Autor:
Joshua A Young, Chin-Wen Chang, Charles Webb Scales, Saurabh V Menon, Chantal E Holy, Caroline Adrienne Blackie
BACKGROUND Identification and referral of at-risk patients from primary care practitioners (PCPs) to eye care professionals remains problematic. Approximately 1.9 million Americans suffer from vision loss as a result of undiagnosed or untreated ophth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01f54804f16ef02db4a8f64fde1952ac
https://doi.org/10.2196/preprints.48295
https://doi.org/10.2196/preprints.48295
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Genome editing in plants typically requires the expression of Cas9 and guide RNA from stably transformed plasmid DNA. Here, the authors show that successful editing can be achieved after delivery of the Cas9-guide RNA complex as a ribonucleoprotein t
Externí odkaz:
https://doaj.org/article/bec7fa9e99f546dab2a3b30180b50be7
Autor:
Charles V. Pollack, Abiy Agiro, Fan Mu, Erin E. Cook, Esteban Lemus Wirtz, Joshua A. Young, Keith A. Betts, Yasmin G. Brahmbhatt
Hyperkalemia is associated with increased healthcare resource utilization (HRU). This study evaluated the impact of sodium zirconium cyclosilicate (SZC) use on HRU in outpatients with hyperkalemia. A retrospective noncomparative study using claims da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759d70487b6528c2b9de55c549a8f4f6
Autor:
Tomas Urbaitis, Giedrius Gasiunas, Joshua K Young, Zhenglin Hou, Sushmitha Paulraj, Egle Godliauskaite, Mantvyda M Juskeviciene, Migle Stitilyte, Monika Jasnauskaite, Megumu Mabuchi, G Brett Robb, Virginijus Siksnys
Publikováno v:
EMBO reports, Hoboken : Wiley, 2022, vol. 23, iss. 12, art. no. e55481, p. [1-15]
Most CRISPR-type V nucleases are stimulated to cleave double-stranded (ds) DNA targets by a T-rich PAM, which restricts their targeting range. Here, we identify and characterize a new family of type V RNA-guided nuclease, Cas12l, that exclusively rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad27a91f59b7039c4602433f8e2cbba
https://pubmed.ncbi.nlm.nih.gov/36268581
https://pubmed.ncbi.nlm.nih.gov/36268581
Autor:
David M. Saylor, Joshua A. Young
Publikováno v:
Regulatory Toxicology and Pharmacology. 141:105405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13e6a4ebfb9e3a6648a387108d716f5b
https://doi.org/10.1016/j.yrtph.2023.105405
https://doi.org/10.1016/j.yrtph.2023.105405