A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS)

Autor: Richard S. Judson, Doris Smith, Michael DeVito, John F. Wambaugh, Barbara A. Wetmore, Katie Paul Friedman, Grace Patlewicz, Russell S. Thomas, Risa R. Sayre, Jennifer H. Olker, Sigmund Degitz, Stephanie Padilla, Joshua A. Harrill, Timothy Shafer, Kelly E. Carstens

Publikováno v: Toxics, Vol 12, Iss 4, p 271 (2024)

Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, c

Externí odkaz: https://doaj.org/article/65a7eaa4eb3848ff8e5cf8a509a96a88

Benchmark Dose Modeling Approaches for Volatile Organic Chemicals Using a Novel Air-Liquid Interface In Vitro Exposure System

Autor: Adam M Speen, Jessica R Murray, Quentin Todd Krantz, David Davies, Paul Evansky, Joshua A Harrill, Logan J Everett, Joseph L Bundy, Lisa A Dailey, Jazzlyn Hill, Wyatt Zander, Elise Carlsten, Michael Monsees, Jose Zavala, Mark A Higuchi

Publikováno v: Toxicol Sci

Inhalation is the most relevant route of volatile organic chemical (VOC) exposure; however, due to unique challenges posed by their chemical properties and poor solubility in aqueous solutions, in vitro chemical safety testing is predominantly perfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53d729c9340cdc51b5aac6c9ddfbf9e
https://doi.org/10.1093/toxsci/kfac040

High-Throughput Transcriptomics Platform for Screening Environmental Chemicals

Autor: Thomas Sheffield, Richard S. Judson, Joseph Bundy, Clinton Willis, Imran Shah, Logan J. Everett, Joshua A. Harrill, Derik E. Haggard, Russell S. Thomas

Publikováno v: Toxicol Sci

New approach methodologies (NAMs) that efficiently provide information about chemical hazard without using whole animals are needed to accelerate the pace of chemical risk assessments. Technological advancements in gene expression assays have made in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92103555f2ab79e8fc49116c99fa654f
https://doi.org/10.1093/toxsci/kfab009

Vision of a near future: Bridging the human health–environment divide

Autor: Lina Gunnarsson, Bruno Campos, Paul L. Carmichael, Andrew White, John K. Colbourne, Geoff Hodges, Matthew P. Dent, Cecilie Rendal, Imran Shah, Carl Westmoreland, Paul Jennings, Claudia Rivetti, Steve Gutsell, Sharon J. Scott, Aude Kienzler, Ian Sorrel, Emma Butler, Luigi Margiotta-Casaluci, Fiona Sewell, Joshua A. Harrill, Richard S. Judson, Iris Muller, Stewart F. Owen, Timothy E. H. Allen, James B. Brown, Francesco Falciani, Mark R. Viant, Paul J. Russell

Publikováno v: Toxicology in Vitro, 62:104692, 1-9. Elsevier Limited
Rivetti, C, Allen, T E H, Brown, J B, Butler, E, Carmichael, P L, Colbourne, J K, Dent, M, Falciani, F, Gunnarsson, L, Gutsell, S, Harrill, J A, Hodges, G, Jennings, P, Judson, R, Kienzler, A, Margiotta-Casaluci, L, Muller, I, Owen, S F, Rendal, C, Russell, P J, Scott, S, Sewell, F, Shah, I, Sorrel, I, Viant, M R, Westmoreland, C, White, A & Campos, B 2020, ' Vision of a near future: Bridging the human health–environment divide : Toward an integrated strategy to understand mechanisms across species for chemical safety assessment ', Toxicology in Vitro, vol. 62, 104692, pp. 1-9 . https://doi.org/10.1016/j.tiv.2019.104692

There is a growing recognition that application of mechanistic approaches to understand cross-species shared molecular targets and pathway conservation in the context of hazard characterization, provide significant opportunities in risk assessment (R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bad4785f71967ae94c513c48dac2fa
https://research.vu.nl/en/publications/e3f48638-347c-4e03-95a4-da43d64ae781

An expert-driven literature review of 'negative' chemicals for developmental neurotoxicity (DNT) in vitro assay evaluation

Autor: Melissa M. Martin, Nancy C. Baker, William K. Boyes, Kelly E. Carstens, Megan E. Culbreth, Mary E. Gilbert, Joshua A. Harrill, Johanna Nyffeler, Stephanie Padilla, Katie Paul Friedman, Timothy J. Shafer

Publikováno v: Neurotoxicology and Teratology. 93:107117

To date, approximately 200 chemicals have been tested in US Environmental Protection Agency (EPA) or Organization for Economic Co-operation and Development (OECD) developmental neurotoxicity (DNT) guideline studies, leaving thousands of chemicals wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0483703eb2e62c82655f5f41bb98386
https://doi.org/10.1016/j.ntt.2022.107117