Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Joshua Ö. Haznedar"'
Autor:
Ellen Y. Wu, Qingling Zhang, Juthamas Sukbuntherng, William Speed, Joshua Ö. Haznedar, Shem Patyna, Geoffrey Peng, David J. Sweeny, Carlo L. Bello, Xiaoming Yu, Lida Antonian
Publikováno v:
Cancer Chemotherapy and Pharmacology. 64:691-706
The purpose of these extensive non-clinical studies was to assess pharmacokinetics and dispositional properties of sunitinib and its primary active metabolite (SU12662). Sunitinib was administered in single and repeat oral doses in mice, rats, and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984caf182fb27ef2932580d6dec97de9
https://doi.org/10.1007/s00280-008-0917-1
https://doi.org/10.1007/s00280-008-0917-1
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 25:821-832
SU5416, Z-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone, is a cytostatic substance in development as an anti-angiogenic agent. SU5416 has several phase I and phase II metabolites including SU9838, SU6595, SU6689, 5′-hydroxy glucuronide of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f758d17d0b80946cb57408dd9a7f8ecc
https://doi.org/10.1016/s0731-7085(01)00341-7
https://doi.org/10.1016/s0731-7085(01)00341-7
Autor:
K. Freshwater, Shem Patyna, Gary W. Chmielewski, Diane Matsumoto, J. Sukbuntherng, Joshua Ö. Haznedar, David L. Morris, Geoffrey Peng
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 86(3)
BACKGROUND: Angiogenesis plays a key role in embryo–fetal development and, based on nonclinical safety data, the majority of vascular endothelial growth factor (VEGF)-targeted antiangiogenic agents used in cancer therapy are not recommended during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8c50ee2288a25af767feac75f4ce6a
https://pubmed.ncbi.nlm.nih.gov/19294680
https://pubmed.ncbi.nlm.nih.gov/19294680
Autor:
Tomas Vojkovsky, Wei-Zhu Zhong, Juthamas Sukbuntherng, Maren Grazzini, Shem Patyna, Dana D. Hu-Lowe, Xueyan Wang, Jeffrey H. Chen, Joshua Ö. Haznedar, Anne-Marie O'Farrell, A. Douglas Laird, Stefan Vasile, Cheng Y. Yang, Christopher Liang, Dirk B. Mendel, Julie M. Cherrington, Huiping Guan
Publikováno v:
Molecular cancer therapeutics. 5(7)
Receptor tyrosine kinases (RTK), such as vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), stem cell factor receptor (KIT), and fms-like tyrosine kinase 3 (FLT3), are expressed in malignant tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b100ecc36d57c75279e1f4b61412cd
https://pubmed.ncbi.nlm.nih.gov/22072801
https://pubmed.ncbi.nlm.nih.gov/22072801
Autor:
Barry L. Taylor, Anuradha Rebbapragada, Alexandre V. Repik, Mark S. Johnson, Igor B. Zhulin, Joshua Ö. Haznedar
PAS domains sense oxygen, redox potential and light, and are implicated in behaviour, circadian rhythmicity, development and metabolic regulation. Although PAS domains are widespread in archaea, bacteria and eukaryota, the mechanism of signal transdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74359ba5267ce9c1271e89c3ba40d2b0
https://europepmc.org/articles/PMC1805630/
https://europepmc.org/articles/PMC1805630/
