Combined inhibition of FGFR4 and VEGFR signaling enhances efficacy in FGF19 driven hepatocellular carcinoma

Autor: Zhao, Xuesong, Joshi, Jaya Julie, Aird, Daniel, Karr, Craig, Yu, Kun, Huang, Chialing, Colombo, Federico, Virrankoski, Milena, Prajapati, Sudeep, Selvaraj, Anand

Publikováno v: Am J Cancer Res

Hepatocellular carcinoma (HCC) is an aggressive liver malignancy that is difficult to treat with no approved biomarker based targeted therapies. FGF19-FGFR4 signaling blockade has been recently identified as a promising avenue for treatment of a subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71367eb35060d2865e4907af74da4c2f
https://europepmc.org/articles/PMC9251677/

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Combined inhibition of FGFR4 and VEGFR signaling enhances efficacy in FGF19 driven hepatocellular carcinoma.

Autor: Zhao X; Department of Discovery, H3 Biomedicine Inc. Cambridge, MA 02139, USA., Joshi JJ; Department of Discovery, H3 Biomedicine Inc. Cambridge, MA 02139, USA., Aird D; Department of Discovery, H3 Biomedicine Inc. Cambridge, MA 02139, USA., Karr C; Department of Discovery, H3 Biomedicine Inc. Cambridge, MA 02139, USA., Yu K; Department of Discovery, H3 Biomedicine Inc. Cambridge, MA 02139, USA., Huang C; Department of Discovery, H3 Biomedicine Inc. Cambridge, MA 02139, USA., Colombo F; Department of Discovery, H3 Biomedicine Inc. Cambridge, MA 02139, USA., Virrankoski M; Department of Discovery, H3 Biomedicine Inc. Cambridge, MA 02139, USA., Prajapati S; Department of Discovery, H3 Biomedicine Inc. Cambridge, MA 02139, USA., Selvaraj A; Department of Discovery, H3 Biomedicine Inc. Cambridge, MA 02139, USA.

Publikováno v: American journal of cancer research [Am J Cancer Res] 2022 Jun 15; Vol. 12 (6), pp. 2733-2743. Date of Electronic Publication: 2022 Jun 15 (Print Publication: 2022).