Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Josh Powe"'
Autor:
David Serra, Vijay R. More, Steven K. Engle, Matthew Gallacher, Prajakta Shimpi, Michael E. Dunn, Nicholas M.P. King, Thomas G. Manfredi, Kathryn E. Gropp, Heidi M. Colton, Josh Powe, Frederick J. Vetter, Luis A Rodriguez, Kevin Agostinucci
Publikováno v:
Toxicologic Pathology. 45:344-352
Given the proven utility of natriuretic peptides as serum biomarkers of cardiovascular maladaptation and dysfunction in humans and the high cross-species sequence conservation of atrial natriuretic peptides, natriuretic peptides have the potential to
Autor:
Gajja S. Salomons, Yong Cang, Scott A. Biller, Hua Yang, Josh Powe, Dongwei Zhu, Stefan Gross, Stuart Murray, Kimberly Straley, Samuel V. Agresta, Karen S. Regan, Katharine E. Yen, Yaguang Si, Mya Steadman, Wei Liu, Lenny Dang, Ana Pop, Yue Chen, Erin Artin, Marion Dorsch, Jeremy Travins, Stephanie Santiago, Shengfang Jin, Muriel D. David, Cyril Quivoron, Andrew Kernytsky, Virginie Penard-Lacronique, Lee Silverman, Chenming Lu, Shin San Michael Su, Zhizhong Lin, Erwin E.W. Jansen, Fang Wang, Eduard A. Struys
Publikováno v:
Journal of Inherited Metabolic Disease
Journal of Inherited Metabolic Disease, 39(6), 807-820. Springer Netherlands
Wang, F, Travins, J, Lin, Z, Si, Y, Chen, Y, Powe, J, Murray, S, Zhu, D, Artin, E, Gross, S, Santiago, S, Steadman, M, Kernytsky, A, Straley, K, Lu, C, Pop, A, Struys, E A, Jansen, E E W, Salomons, G S, David, M D, Quivoron, C, Penard-Lacronique, V, Regan, K S, Liu, W, Dang, L, Yang, H, Silverman, L, Agresta, S, Dorsch, M, Biller, S, Yen, K, Cang, Y, Su, S S M & Jin, S 2016, ' A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model ', Journal of Inherited Metabolic Disease, vol. 39, no. 6, pp. 807-820 . https://doi.org/10.1007/s10545-016-9960-y
Journal of Inherited Metabolic Disease, 39(6), 807-820. Springer Netherlands
Wang, F, Travins, J, Lin, Z, Si, Y, Chen, Y, Powe, J, Murray, S, Zhu, D, Artin, E, Gross, S, Santiago, S, Steadman, M, Kernytsky, A, Straley, K, Lu, C, Pop, A, Struys, E A, Jansen, E E W, Salomons, G S, David, M D, Quivoron, C, Penard-Lacronique, V, Regan, K S, Liu, W, Dang, L, Yang, H, Silverman, L, Agresta, S, Dorsch, M, Biller, S, Yen, K, Cang, Y, Su, S S M & Jin, S 2016, ' A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model ', Journal of Inherited Metabolic Disease, vol. 39, no. 6, pp. 807-820 . https://doi.org/10.1007/s10545-016-9960-y
D-2-hydroxyglutaric aciduria (D2HGA) type II is a rare neurometabolic disorder caused by germline gain-of-function mutations in isocitrate dehydrogenase 2 (IDH2), resulting in accumulation of D-2-hydroxyglutarate (D2HG). Patients exhibit a wide spect
Autor:
John Newcomb, James M. Gavin, Nancy J. Bump, Stephen Tirrell, Lawrence R. Dick, Saurabh Menon, Jessica Huck, Petter Veiby, Benjamin S. Amidon, Yu Yang, Marc L. Hyer, Paul D. Greenspan, Fleming Paul E, Teresa A. Soucy, Jim Brownell, Michael Sintchak, Josh Powe, Steve Langston, Mark Manfredi, Judy Shi, Jeff Ciavarri, Darshan S. Sappal, Frank Bruzzese, Mike Kuranda, Katherine Galvin, Michael Milhollen, Ping Li, Neil F. Bence, Jing Tao Wu, Claudia Rabino, Chris Claiborne, Tary Traore, Jennifer Duffy, Jessica Riceberg, Robert J. Griffin, Kara Hoar, Anya Lublinsky, Bradley Stringer, Sai M Pulukuri
Publikováno v:
Nature medicine. 24(2)
The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic potential of this pathway has been validated by the clinical successes of a number of UPS modulator