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A phase I open-label study to investigate safety and tolerability, efficacy, pharmacokinetics, pharmacodynamics, and immunogenicity of MT-5111 in subjects with HER-2 positive tumors

Autor: Brian Andrew Van Tine, Minal A. Barve, Erika Paige Hamilton, Andrew Jacob Brenner, Zev A. Wainberg, Christine Burnett, Josh Pelham, Brigitte Brieschke, Thomas Strack

Publikováno v: Journal of Clinical Oncology. 38:TPS465-TPS465

TPS465 Background: Engineered toxin bodies (ETBs) are proprietarily engineered from a Shiga-like Toxin A subunit fused to antibody-like binding domains. ETBs can force receptor internalization, self-route to the cytosol, and induce cell-kill via inac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26b04e6ae13e199ba1338ee9e871477d
https://doi.org/10.1200/jco.2020.38.4_suppl.tps465

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