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Autor:
Kari L. Deranian, Diana M. Bautista, Colleen Mcnamara, Josh Mandel-Brehm, David Julius, Michael Zhao, Magdalene M. Moran, Jan Siemens, Jayhong A. Chong, Neil Hayward, Christopher M. Fanger
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(33)
The formalin model is widely used for evaluating the effects of analgesic compounds in laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; the first phase is thought to result from direct activation of primar