Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Joses Ho"'
Autor:
Alexandra Sakai, Gagandeep Singh, Mahsa Khoshbakht, Scott Bittner, Christiane V. Löhr, Randy Diaz-Tapia, Prajakta Warang, Kris White, Luke Le Luo, Blanton Tolbert, Mario Blanco, Amy Chow, Mitchell Guttman, Cuiping Li, Yiming Bao, Joses Ho, Sebastian Maurer-Stroh, Arnab Chatterjee, Sumit Chanda, Adolfo García-Sastre, Michael Schotsaert, John R. Teijaro, Hong M. Moulton, David A. Stein
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102331- (2024)
Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority. Here, we report that an antisense peptide-conjugated morpholino oligomer (PPMO) named 5′END-2, targeting a highly conserved
Externí odkaz:
https://doaj.org/article/cde8602c5de243599a35a2d086e74e3b
Autor:
Anderson F. Brito, Elizaveta Semenova, Gytis Dudas, Gabriel W. Hassler, Chaney C. Kalinich, Moritz U. G. Kraemer, Joses Ho, Houriiyah Tegally, George Githinji, Charles N. Agoti, Lucy E. Matkin, Charles Whittaker, Bulgarian SARS-CoV-2 sequencing group, Communicable Diseases Genomics Network (Australia and New Zealand), COVID-19 Impact Project, Danish Covid-19 Genome Consortium, Fiocruz COVID-19 Genomic Surveillance Network, GISAID core curation team, Network for Genomic Surveillance in South Africa (NGS-SA), Swiss SARS-CoV-2 Sequencing Consortium, Benjamin P. Howden, Vitali Sintchenko, Neta S. Zuckerman, Orna Mor, Heather M. Blankenship, Tulio de Oliveira, Raymond T. P. Lin, Marilda Mendonça Siqueira, Paola Cristina Resende, Ana Tereza R. Vasconcelos, Fernando R. Spilki, Renato Santana Aguiar, Ivailo Alexiev, Ivan N. Ivanov, Ivva Philipova, Christine V. F. Carrington, Nikita S. D. Sahadeo, Ben Branda, Céline Gurry, Sebastian Maurer-Stroh, Dhamari Naidoo, Karin J. von Eije, Mark D. Perkins, Maria van Kerkhove, Sarah C. Hill, Ester C. Sabino, Oliver G. Pybus, Christopher Dye, Samir Bhatt, Seth Flaxman, Marc A. Suchard, Nathan D. Grubaugh, Guy Baele, Nuno R. Faria
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
In this study, the authors provide a global overview of SARS-CoV-2 genome sequencing, and estimate the proportion of cases sequenced and time to genome upload. They identify disparities and highlight the need to strengthen surveillance in lower and m
Externí odkaz:
https://doaj.org/article/4ffaf8318aae4bf29738c1ee85ab524c
Autor:
Gadisti Aisha Mohamed, Ruey-Kuang Cheng, Joses Ho, Seetha Krishnan, Farhan Mohammad, Adam Claridge-Chang, Suresh Jesuthasan
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-12 (2017)
Abstract Background Optical silencing of activity provides a way to test the necessity of neurons in behaviour. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown to potently inhibit activity in cultured mammalian neurons and
Externí odkaz:
https://doaj.org/article/0250215fab9340d3a7a6670997ea0a57
Autor:
Sonja C Vernes, Peter L Oliver, Elizabeth Spiteri, Helen E Lockstone, Rathi Puliyadi, Jennifer M Taylor, Joses Ho, Cedric Mombereau, Ariel Brewer, Ernesto Lowy, Jérôme Nicod, Matthias Groszer, Dilair Baban, Natasha Sahgal, Jean-Baptiste Cazier, Jiannis Ragoussis, Kay E Davies, Daniel H Geschwind, Simon E Fisher
Publikováno v:
PLoS Genetics, Vol 7, Iss 7, p e1002145 (2011)
Forkhead-box protein P2 is a transcription factor that has been associated with intriguing aspects of cognitive function in humans, non-human mammals, and song-learning birds. Heterozygous mutations of the human FOXP2 gene cause a monogenic speech an
Externí odkaz:
https://doaj.org/article/a950a2c8de904895877d01abff0f551a
Autor:
Farhan Mohammad, Yishan Mai, Joses Ho, Xianyuan Zhang, Stanislav Ott, James Charles Stewart, Adam Claridge-Chang
The brain must guide immediate responses to beneficial and harmful stimuli while simultaneously writing memories for future reference. Both immediate actions and reinforcement learning are instructed by dopamine. However, it is unknown how dopaminerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::673af2c6d4a08d543123292ca7dafdea
https://doi.org/10.1101/2022.11.23.517775
https://doi.org/10.1101/2022.11.23.517775
Autor:
Oon Tek Ng, Kalisvar Marimuthu, Nigel Lim, Ze Qin Lim, Natascha May Thevasagayam, Vanessa Koh, Calvin J. Chiew, Stefan Ma, Mingshi Koh, Pin Yan Low, Say Beng Tan, Joses Ho, Sebastian Maurer-Stroh, Vernon J. M. Lee, Yee-Sin Leo, Kelvin Bryan Tan, Alex R. Cook, Chorh Chuan Tan
Publikováno v:
JAMA Network Open. 5:e2228900
ImportanceAssessing booster effectiveness of COVID-19 mRNA vaccine and inactivated SARS-CoV-2 vaccine over longer time intervals and in response to any further SARS-CoV-2 variants is crucial in determining optimal COVID-19 vaccination strategies.Obje
Autor:
Katarina Chlebikova, James C. Stewart, Tong-Wey Koh, Adam Claridge-Chang, Jia Yi Chua, Stanislav Ott, Joses Ho, Farhan Mohammad
Publikováno v:
Nature Methods. 14:271-274
Optogenetics uses light exposure to manipulate physiology in genetically modified organisms. Abundant tools for optogenetic excitation are available, but the limitations of current optogenetic inhibitors present an obstacle to demonstrating the neces
Autor:
James C. Stewart, Sherry Shiying Aw, Eng-King Tan, Lin Gu, Li Cheng, Joses Ho, Camilo Libedinsky, Adam Claridge-Chang, Boon Hui Wong, Malvika Katarya, Daiqin Li, Lakshmi Narasimhan Govindarajan, Kah Junn Tan, Shuang Wu
Publikováno v:
PLoS Biology, Vol 17, Iss 6, p e3000346 (2019)
PLoS Biology
PLoS Biology
Some neurodegenerative diseases, like Parkinsons Disease (PD) and Spinocerebellar ataxia 3 (SCA3), are associated with distinct, altered gait and tremor movements that are reflective of the underlying disease etiology. Drosophila melanogaster models
Autor:
Lakshmi Narasimhan Govindarajan, Boon Hui Wong, Lin Gu, Adam Claridge-Chang, Eng-King Tan, Malvika Katarya, Daiqin Li, James C. Stewart, Kah Junn Tan, Sherry Shiying Aw, Shuang Wu, Camilo Libedinsky, Joses Ho, Li Cheng
SummaryGenetic models inDrosophilahave made invaluable contributions to our understanding of the molecular mechanisms underlying neurodegeneration. In human patients, some neurodegenerative diseases lead to characteristic movement dysfunctions, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8814674391350d4b17268725c44142b
https://doi.org/10.1101/425405
https://doi.org/10.1101/425405
Over the past 75 years, a number of statisticians have advised that the data-analysis method known as null-hypothesis significance testing (NHST) should be deprecated (Berkson, 1942; Halsey et al., 2015; Wasserstein et al., 2019). The limitations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7620e7effb466d648a8626f06c2bc403