Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Josephine R. Giles"'
Autor:
Susan E. McClory, Oishi Bardhan, Kelly S. Rome, Josephine R. Giles, Amy E. Baxter, Lanwei Xu, Phyllis A. Gimotty, Robert B. Faryabi, E. John Wherry, Warren S. Pear, Martha S. Jordan
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112905- (2023)
Summary: CD8+ T cell exhaustion (TEX) impairs the ability of T cells to clear chronic infection or cancer. While TEX are hypofunctional, some TEX retain effector gene signatures, a feature associated with killer lectin-like receptor (KLR) expression.
Externí odkaz:
https://doaj.org/article/649d5307b00c4acca7e424a01f75bf3e
Autor:
Caroline Diorio, Rawan Shraim, Laura A. Vella, Josephine R. Giles, Amy E. Baxter, Derek A. Oldridge, Scott W. Canna, Sarah E. Henrickson, Kevin O. McNerney, Frances Balamuth, Chakkapong Burudpakdee, Jessica Lee, Tomas Leng, Alvin Farrel, Michele P. Lambert, Kathleen E. Sullivan, E. John Wherry, David T. Teachey, Hamid Bassiri, Edward M. Behrens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Multi-inflammatory syndrome in children (MIS-C) can be associated with SARS-CoV-2 infection but can also be similar to other inflammatory syndromes. Here the authors characterise the plasma proteome phenotype in MIS-C and compare to other SARS-CoV-2
Externí odkaz:
https://doaj.org/article/a888480056e0487995e0516acf1b06ce
Autor:
Carter Merenstein, Guanxiang Liang, Samantha A. Whiteside, Ana G. Cobián-Güemes, Madeline S. Merlino, Louis J. Taylor, Abigail Glascock, Kyle Bittinger, Ceylan Tanes, Jevon Graham-Wooten, Layla A. Khatib, Ayannah S. Fitzgerald, Shantan Reddy, Amy E. Baxter, Josephine R. Giles, Derek A. Oldridge, Nuala J. Meyer, E. John Wherry, John E. McGinniss, Frederic D. Bushman, Ronald G. Collman
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
Externí odkaz:
https://doaj.org/article/4210de6591cd4fcdb3d6cb3838f991b6
Autor:
Sokratis A. Apostolidis, Amrita Sarkar, Heather M. Giannini, Rishi R. Goel, Divij Mathew, Aae Suzuki, Amy E. Baxter, Allison R. Greenplate, Cécile Alanio, Mohamed Abdel-Hakeem, Derek A. Oldridge, Josephine R. Giles, Jennifer E. Wu, Zeyu Chen, Yinghui Jane Huang, Jonathan Belman, Ajinkya Pattekar, Sasikanth Manne, Oliva Kuthuru, Jeanette Dougherty, Brittany Weiderhold, Ariel R. Weisman, Caroline A. G. Ittner, Sigrid Gouma, Debora Dunbar, Ian Frank, Alexander C. Huang, Laura A. Vella, The UPenn COVID Processing Unit, John P. Reilly, Scott E. Hensley, Lubica Rauova, Liang Zhao, Nuala J. Meyer, Mortimer Poncz, Charles S. Abrams, E. John Wherry, Sharon Adamski, Zahidul Alam, Mary M. Addison, Katelyn T. Byrne, Aditi Chandra, Hélène C. Descamps, Nicholas Han, Yaroslav Kaminskiy, Shane C. Kammerman, Justin Kim, Jacob T. Hamilton, Nune Markosyan, Julia Han Noll, Dalia K. Omran, Eric Perkey, Elizabeth M. Prager, Dana Pueschl, Austin Rennels, Jennifer B. Shah, Jake S. Shilan, Nils Wilhausen, Ashley N. Vanderbeck
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with hyperinflamm
Externí odkaz:
https://doaj.org/article/f380b6f884834140a346b9249d88cbb6
Autor:
Carter Merenstein, Guanxiang Liang, Samantha A. Whiteside, Ana G. Cobián-Güemes, Madeline S. Merlino, Louis J. Taylor, Abigail Glascock, Kyle Bittinger, Ceylan Tanes, Jevon Graham-Wooten, Layla A. Khatib, Ayannah S. Fitzgerald, Shantan Reddy, Amy E. Baxter, Josephine R. Giles, Derek A. Oldridge, Nuala J. Meyer, E. John Wherry, John E. McGinniss, Frederic D. Bushman, Ronald G. Collman
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Viral infection of the respiratory tract can be associated with propagating effects on the airway microbiome, and microbiome dysbiosis may influence viral disease. Here, we investigated the respiratory tract microbiome in coronavirus disease
Externí odkaz:
https://doaj.org/article/ca5cad2815fe4e0a812dfa0c43ae79ec
Autor:
Bence Daniel, Kathryn E. Yost, Sunnie Hsiung, Katalin Sandor, Yu Xia, Yanyan Qi, Kamir J. Hiam-Galvez, Mollie Black, Colin J. Raposo, Quanming Shi, Stefanie L. Meier, Julia A. Belk, Josephine R. Giles, E. John Wherry, Howard Y. Chang, Takeshi Egawa, Ansuman T. Satpathy
Publikováno v:
Nature Immunology. 23:1614-1627
Autor:
Josephine R. Giles, Shin Foong Ngiow, Sasikanth Manne, Amy E. Baxter, Omar Khan, Ping Wang, Ryan Staupe, Mohamed S. Abdel-Hakeem, Hua Huang, Divij Mathew, Mark M. Painter, Jennifer E. Wu, Yinghui Jane Huang, Rishi R. Goel, Patrick K. Yan, Giorgos C. Karakousis, Xiaowei Xu, Tara C. Mitchell, Alexander C. Huang, E. John Wherry
Publikováno v:
Nature Immunology. 23:1600-1613
Autor:
Samantha L. Bucktrout, Nicholas E. Banovich, Lisa H. Butterfield, Cansu Cimen-Bozkus, Josephine R. Giles, Zinaida Good, Daniel Goodman, Vanessa D. Jonsson, Caleb Lareau, Alexander Marson, Denna M. Maurer, Paul V. Munson, Mike Stubbington, Sarah Taylor, Abbey Cutchin
Publikováno v:
Nature Medicine. 28:1761-1764
Autor:
Jennifer E. Wu, Sasikanth Manne, Shin Foong Ngiow, Amy E. Baxter, Hua Huang, Elizabeth Freilich, Megan L. Clark, Joanna H. Lee, Zeyu Chen, Omar Khan, Ryan P. Staupe, Yinghui J. Huang, Junwei Shi, Josephine R. Giles, E. John Wherry
Publikováno v:
bioRxiv
Identifying novel molecular mechanisms of exhausted CD8 T cells (Tex) is a key goal of improving immunotherapy of cancer and other diseases. However, high-throughput interrogation ofin vivoTexcan be costly and inefficient.In vitromodels of Texare eas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41ec6b7f1a1cbd79f8e158021783d81
https://europepmc.org/articles/PMC10153201/
https://europepmc.org/articles/PMC10153201/
Autor:
Susan E. McClory, Oishi Bardhan, Kelly S. Rome, Josephine R. Giles, Amy E. Baxter, Lanwei Xu, Phyllis A. Gimotty, Robert B. Faryabi, E. John Wherry, Warren S. Pear, Martha S. Jordan
Publikováno v:
bioRxiv
T cell exhaustion (TEX) impairs the ability of T cells to clear chronic infection or cancer. While exhausted T cells are hypofunctional, some exhausted T cells retain effector gene signatures, a feature that is associated with expression of KLRs (kil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d3a0f4a714c5d6cda81d3fb63ffacc
https://europepmc.org/articles/PMC9948998/
https://europepmc.org/articles/PMC9948998/