Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Josephine Lok"'
Autor:
Tomonori Hoshino, Hajime Takase, Gen Hamanaka, Shintaro Kimura, Norito Fukuda, Emiri T. Mandeville, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The corpus callosum, a major white matter tract in the brain, undergoes age-related functional changes. To extend our investigation of age-related gene expression dynamics in the mouse corpus callosum, we compared RNA-seq data from 2 week-ol
Externí odkaz:
https://doaj.org/article/12e7aa4247b14b01a7b23aaf731dc7e4
Autor:
Tomonori Hoshino, Hajime Takase, Hidehiro Ishikawa, Gen Hamanaka, Shintaro Kimura, Norito Fukuda, Ji Hyun Park, Hiroki Nakajima, Hisashi Shirakawa, Akihiro Shindo, Kyu-Won Kim, Irwin H Gelman, Josephine Lok, Ken Arai
Publikováno v:
Bioinformatics and Biology Insights, Vol 18 (2024)
A-kinase anchor protein 12 (AKAP12), a scaffold protein, has been implicated in the central nervous system, including blood-brain barrier (BBB) function. Although its expression level in the corpus callosum is higher than in other brain regions, such
Externí odkaz:
https://doaj.org/article/1fd76de251144c16af1a0bf481a6830d
Autor:
Ning Liu, Jinrui Han, Yadan Li, Yinghua Jiang, Samuel X. Shi, Josephine Lok, Michael Whalen, Aaron S. Dumont, Xiaoying Wang
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background Traumatic brain injury (TBI) is a significant cause of death and disability worldwide. The TLR4-NFκB signaling cascade is the critical pro-inflammatory activation pathway of leukocytes after TBI, and modulating this signaling cas
Externí odkaz:
https://doaj.org/article/922b7f40a5f2438fa7c9c792a4b53768
Autor:
Ryo Ohtomo, Hidehiro Ishikawa, Keita Kinoshita, Kelly K. Chung, Gen Hamanaka, Gaku Ohtomo, Hajime Takase, Christiane D. Wrann, Hiroshi Katsuki, Atsushi Iwata, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Clinical and basic research suggests that exercise is a safe behavioral intervention and is effective for improving cognitive function in cerebrovascular diseases, including subcortical ischemic vascular dementia (SIVD). However, most of the basic re
Externí odkaz:
https://doaj.org/article/9edc09523ab84bf68816a3ad42d52779
Autor:
Chongjie Cheng, Xiaoshu Wang, Yinghua Jiang, Yadan Li, Zhengbu Liao, Wenlu Li, Zhanyang Yu, Michael J. Whalen, Josephine Lok, Aaron S. Dumont, Ning Liu, Xiaoying Wang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Microvascular failure is one of the key pathogenic factors in the dynamic pathological evolution after traumatic brain injury (TBI). Our laboratory and others previously reported that Annexin A2 functions in blood-brain barrier (BBB) development and
Externí odkaz:
https://doaj.org/article/5eb0d87c27504fd2bd52c4b89f5831f6
Autor:
Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Hidehiro Ishikawa, Kelly K. Chung, Emiri T. Mandeville, Josephine Lok, Myriam Fornage, Karl Herrup, Kai-Hei Tse, Eng H. Lo, Ken Arai
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
White matter damage caused by cerebral hypoperfusion is a major hallmark of subcortical ischemic vascular dementia (SIVD), which is the most common subtype of vascular cognitive impairment and dementia (VCID) syndrome. In an aging society, the number
Externí odkaz:
https://doaj.org/article/25f21b31cb26423c8c40c5188442765d
Publikováno v:
Brain Circulation, Vol 4, Iss 3, Pp 118-123 (2018)
There are currently no adequate treatments for white-matter injury, which often follows central nervous system maladies and their accompanying neurodegenerative processes. Indeed, the white matter is compromised by the deterioration of the blood–br
Externí odkaz:
https://doaj.org/article/ffb5b754e86a4afbbf003fc7a5643a8a
Autor:
Ji Hae Seo, Takakuni Maki, Nobukazu Miyamoto, Yoon Kyong Choi, Kelly K. Chung, Gen Hamanaka, Ji Hyun Park, Emiri T. Mandeville, Hajime Takase, Kazuhide Hayakawa, Josephine Lok, Irwin H. Gelman, Kyu-Won Kim, Eng H. Lo, Ken Arai
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9078 (2020)
A-kinase anchor protein 12 (AKAP12) is a scaffolding protein that associates with intracellular molecules to regulate multiple signal transductions. Although the roles of AKAP12 in the central nervous system are still relatively understudied, it was
Externí odkaz:
https://doaj.org/article/a530e485410749549741b8fa74292755
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 9, Pp 1550-1551 (2018)
Externí odkaz:
https://doaj.org/article/2131a0a697c64bb295ceaa738a7d39f4
Autor:
Kelly K Chung, Mia C Borlongan, Eng H. Lo, Ken Arai, Ryosuke Takahashi, Naohiro Egawa, Gen Hamanaka, Takakuni Maki, Hidekazu Tomimoto, Hajime Takase, Akihiro Shindo, Josephine Lok, Emiri T. Mandeville
Publikováno v:
CNS Neuroscience & Therapeutics
Recent clinical studies suggest that pentraxin 3 (PTX3), which is known as an acute‐phase protein that is produced rapidly at local sites of inflammation, may be a new biomarker of disease risk for central nervous system disorders, including stroke