Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Josephine L Meade"'
Autor:
Erica B Wilson, Jehan J El-Jawhari, Abbie L Neilson, Geoffrey D Hall, Alan A Melcher, Josephine L Meade, Graham P Cook
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e22842 (2011)
Immune evasion is now recognized as a key feature of cancer progression. In animal models, the activity of cytotoxic lymphocytes is suppressed in the tumour microenvironment by the immunosuppressive cytokine, Transforming Growth Factor (TGF)-β. Rele
Externí odkaz:
https://doaj.org/article/20d56bb28df2483d9ebfcbba024203d3
Autor:
Gina B. Scott, Yasser M. El-Sherbiny, G. Eric Blair, Graham P. Cook, Terence H. Rabbitts, Josephine L. Meade, Tomoyuki Tanaka, Jehan J. El-Jawhari, Robin Prestwich, Ruth Morgan, Paul A. Bowles
Mutations in the RAS family of oncogenes are highly prevalent in human cancer and, amongst its manifold effects, oncogenic RAS impairs the expression of components of the antigen presentation pathway. This allows evasion of cytotoxic T lymphocytes (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3878183a9f7dd06bdf85b8a3d8243c82
https://ora.ox.ac.uk/objects/uuid:0f109c39-e694-4c30-8028-9aa3f3533e0a
https://ora.ox.ac.uk/objects/uuid:0f109c39-e694-4c30-8028-9aa3f3533e0a
Publikováno v:
Briefings in Functional Genomics and Proteomics. 7:8-16
Natural killer (NK) cells are lymphocytes with an innate ability to recognize and kill infected cells and tumour cells. Unlike B and T cells, NK cells do not express an antigen receptor. Instead, NK cells detect changes in the phenotype of the target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d253a4e1603648de16d60a724f925e
https://doi.org/10.1093/bfgp/elm037
https://doi.org/10.1093/bfgp/elm037
Autor:
Abbie Louise Neilson, Graham P. Cook, Jehan J. El-Jawhari, Erica B. Wilson, Alan Melcher, Josephine L. Meade, Geoffrey Hall
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 9, p e22842 (2011)
PLoS ONE, Vol 6, Iss 9, p e22842 (2011)
Immune evasion is now recognized as a key feature of cancer progression. In animal models, the activity of cytotoxic lymphocytes is suppressed in the tumour microenvironment by the immunosuppressive cytokine, Transforming Growth Factor (TGF)-β. Rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4fa462231a0e7018360b736797c5f1
http://europepmc.org/articles/PMC3167809
http://europepmc.org/articles/PMC3167809
Autor:
Michael F. McDermott, Tim D. Holmes, Liz Straszynski, Erika A. de Wynter, Peter Brett, Paul A. S. Ballard, Joseph A. Trapani, Erica B. Wilson, Josephine L. Meade, Graham P. Cook
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 183(2)
NK cells induce apoptosis in target cells via the perforin-mediated delivery of granzyme molecules. Cytotoxic human NK cells can be generated by IL-15-mediated differentiation of CD34+ cells in vitro and these cultures have been used extensively to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0079dc1c666210f711cbe6c848c5c7e4
https://pubmed.ncbi.nlm.nih.gov/19570824
https://pubmed.ncbi.nlm.nih.gov/19570824
Autor:
Graham P. Cook, Yasser M. El-Sherbiny, Stephen J. Richards, Sylvia Feyler, Tim D. Holmes, Ann W. Morgan, Dennis McGonagle, Faith E. Davies, Gareth J. Morgan, Sarah L. Mackie, Josephine L. Meade, Gordon Cook
Publikováno v:
Cancer research. 67(18)
Recent evidence suggests a role for natural killer (NK) cells in the control of multiple myeloma. We show that expression of the NK cell receptor DNAM-1 (CD226) is reduced on CD56dim NK cells from myeloma patients with active disease compared with pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d6b979de68fba89b759cc61e45a731
https://pubmed.ncbi.nlm.nih.gov/17875681
https://pubmed.ncbi.nlm.nih.gov/17875681
Publikováno v:
Molecularcellular proteomics : MCP. 6(5)
Natural killer (NK) cells and cytotoxic T lymphocytes eliminate virally infected and transformed cells. Target cell killing is mediated by the regulated exocytosis of secretory lysosomes, which deliver perforin and proapoptotic granzymes to the infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3255045a04556317af42cd174cb8b995
https://pubmed.ncbi.nlm.nih.gov/17272266
https://pubmed.ncbi.nlm.nih.gov/17272266
Autor:
C. Geoffrey Woods, Erika A. de Wynter, Josephine L. Meade, Saghira Malik Sharif, Graham P. Cook, Alexander F. Markham, Peter Brett
Publikováno v:
Blood. 107(9)
Activation of granzyme B, a key cytolytic effector molecule of natural killer (NK) cells, requires removal of an N-terminal pro-domain. In mice, cathepsin C is required for granzyme processing and normal NK cell cytolytic function, whereas in patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9e9d33a10d470b42034771a1b88bad
https://pubmed.ncbi.nlm.nih.gov/16410452
https://pubmed.ncbi.nlm.nih.gov/16410452
Publikováno v:
Virology. 338(2)
Adenovirus (Ad) E1A is a potent oncogene and has been shown to deregulate the expression of a large number of cellular genes leading to cellular transformation. Here we have analysed the expression of several immunomodulatory molecules on the surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b7a4969c01948f261ff8f4ebd99d1e
https://pubmed.ncbi.nlm.nih.gov/15963548
https://pubmed.ncbi.nlm.nih.gov/15963548
Autor:
Mark A. Hull, Alexander F. Markham, Bettina Mühl, P. Louise Coletta, Josephine L. Meade, Deborah Clarke, Sarah Holwell, Constanze Bonifer, Graham P. Cook, Frederique Ponchel, Gillian Hawcroft, Albrecht M. Müller, Elena Jones, Wai K. Lam, Ken A. MacLennan
Publikováno v:
Blood. 103(3)
Germ line mutations in the Adenomatous polyposis coli tumor suppressor gene cause a hereditary form of intestinal tumorigenesis in both mice and man. Here we show that in ApcMin/+ mice, which carry a heterozygous germ line mutation at codon 850 of Ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e128431bcf81603db26c6a95160382
https://pubmed.ncbi.nlm.nih.gov/14525778
https://pubmed.ncbi.nlm.nih.gov/14525778