Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Josephine L Klitgaard"'
Autor:
Caroline Holm Nørgaard, Lasse Hjort Jakobsen, Andrew J Gentles, Karen Dybkær, Tarec Christoffer El-Galaly, Julie Støve Bødker, Alexander Schmitz, Preben Johansen, Tobias Herold, Karsten Spiekermann, Jennifer R Brown, Josephine L Klitgaard, Hans Erik Johnsen, Martin Bøgsted
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193249 (2018)
Diagnostic and prognostic evaluation of chronic lymphocytic leukemia (CLL) involves blood cell counts, immunophenotyping, IgVH mutation status, and cytogenetic analyses. We generated B-cell associated gene-signatures (BAGS) based on six naturally occ
Externí odkaz:
https://doaj.org/article/54d6f02da4e545279292e8d9f730b34d
Autor:
Jennifer R. Brown, Sunita R. Setlur, Gad Getz, Charles Lee, Josephine L. Klitgaard, Saranya Radhakrishnan, Stacey M. Fernandes, Reina Improgo, Bethany Tesar, Andrew Aw, Kevin Hoang, Wei Du, Parul Benien, Siddha N. Kasar, Haesook T. Kim, Lijian Yu
Table S1. Minimally deleted regions (MDR) of recurrent deletions. Table S2. Clinical features of the patients in this study. Table S3. Overall survival is correlated with total copy number events and somatic mutations. Table S4. Details of the RPS15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f14ba1af0279d843c81f86abbdcf719
https://doi.org/10.1158/1078-0432.22464900
https://doi.org/10.1158/1078-0432.22464900
Autor:
Catherine J. Wu, Arnold S. Freedman, Stacey M. Fernandes, Eric D. Jacobsen, Josephine L. Klitgaard, Matthew S. Davids, Jennifer R. Brown, Michael Xiang, Erik A. Nelson, Sarah R. Walker, Zachary T. Giaccone, Maria Nicolais, Jennifer E. Yeh, Mousumi Chaudhury, Svitlana Tyekucheva, Yasmin Kroll, David C. Fisher, Lisa N. Heppler, Jeffrey G. Supko, David A. Frank
Publikováno v:
Am J Hematol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f730dddc3d8b54c3dae3b58afdd506
https://europepmc.org/articles/PMC7954938/
https://europepmc.org/articles/PMC7954938/
Autor:
Jennifer R. Brown, Saranya Radhakrishnan, Sunita R. Setlur, Reina Improgo, Lijian Yu, Gad Getz, Kevin Hoang, Parul Benien, Stacey M. Fernandes, Charles Lee, Josephine L. Klitgaard, Haesook T. Kim, Bethany Tesar, Siddha Kasar, Wei Du, Andrew Aw
Publikováno v:
Clinical Cancer Research. 23:735-745
Purpose: Chronic lymphocytic leukemia (CLL) with 17p deletion typically progresses quickly and is refractory to most conventional therapies. However, some del(17p) patients do not progress for years, suggesting that del(17p) is not the only driving e
Autor:
Jennifer R. Brown, Divya Chaudhary, Bethany Tesar, Haesook T. Kim, Stacey M. Fernandes, Reuma Magori-Cohen, Lijian Yu, William F. Westlin, Siddha Kasar, Kevin Hoang, Ma. Reina Improgo, Wenyan Miao, Josephine L. Klitgaard
Publikováno v:
British Journal of Haematology.
The L265P somatic mutation in the Myeloid Differentiation Primary Response 88 (MYD88) gene is a recurrent mutation in chronic lymphocytic leukaemia (CLL). This mutation has functional effects in various haematological malignancies but its role in CLL
Autor:
Josephine L. Klitgaard, Siddha Kasar, Deepti Gadi, Donald R. Polaski, Qiyuan Li, Matthew L. Freedman, Alexander J. Federation, Christopher J. Ott, Stacey M. Fernandes, Amanda Souza, James E. Bradner, Romina E. Lenci, Jennifer R. Brown, Matthew A. Lawlor, Logan Schwartz
Enhancer profiling is a powerful approach for discovering cis-regulatory elements that define the core transcriptional regulatory circuits of normal and malignant cells. Gene control through enhancer activity is often dominated by a subset of lineage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75dbad923dceb29064f184d31c23aa8
https://europepmc.org/articles/PMC6298230/
https://europepmc.org/articles/PMC6298230/
Autor:
Sarah R. Walker, Erik Nelson, David A. Frank, Catherine J. Wu, Stacey M. Fernandes, Svitlana Tyekucheva, Michael Xiang, Zachary T. Giaccone, Lisa N. Heppler, Maria Nicolais, Jennifer R. Brown, Jeffrey G. Supko, Josephine L. Klitgaard, Jennifer E. Yeh, Mousumi Chaudhury, Yasmin Kroll
Publikováno v:
Blood. 132:1855-1855
Despite advances in targeted therapy, chronic lymphocytic leukemia (CLL) remains a highly prevalent and essentially incurable malignancy. One molecular hallmark of CLL is the constitutive serine phosphorylation and transcriptional activation of the o
Autor:
Sarah R. Walker, Ellen Weisberg, Shariya Terrell, David A. Frank, Michal Bar-Natan, Martha R. Addorio, Laurie B. Gashin, Josephine L. Klitgaard, Erik A. Nelson, James D. Griffin, Loredana Santo, Rosemary Barrett, Benjamin L. Ebert
Publikováno v:
Blood. 117:3421-3429
The transcription factor STAT5 is an essential mediator of the pathogenesis of chronic myelogenous leukemia (CML). In CML, the BCR/ABL fusion kinase causes the constitutive activation of STAT5, thereby driving the expression of genes promoting surviv
Autor:
Tobias Herold, Andrew J. Gentles, Hans Erik Johnsen, Martin Bøgsted, Josephine L. Klitgaard, Jennifer R. Brown, Preben Johansen, Lasse Hjort Jakobsen, Karsten Spiekermann, Julie Støve Bødker, Karen Dybkær, Tarec Christoffer El-Galaly, Alexander Schmitz, Caroline Holm Nørgaard
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193249 (2018)
Nørgaard, C H, Jakobsen, L H, Gentles, A J, Dybkær, K, El-Galaly, T C, Bødker, J S, Schmitz, A, Johansen, P, Herold, T, Spiekermann, K, Brown, J R, Klitgaard, J L, Johnsen, H E & Bøgsted, M 2018, ' Subtype assignment of CLL based on B-cell subset associated gene signatures from normal bone marrow – A proof of concept study ', PLOS ONE, vol. 13, no. 3, e0193249, pp. e0193249 . https://doi.org/10.1371/journal.pone.0193249
PLoS ONE
Nørgaard, C H, Jakobsen, L H, Gentles, A J, Dybkær, K, El-Galaly, T C, Bødker, J S, Schmitz, A, Johansen, P, Herold, T, Spiekermann, K, Brown, J R, Klitgaard, J L, Johnsen, H E & Bøgsted, M 2018, ' Subtype assignment of CLL based on B-cell subset associated gene signatures from normal bone marrow – A proof of concept study ', PLOS ONE, vol. 13, no. 3, e0193249, pp. e0193249 . https://doi.org/10.1371/journal.pone.0193249
PLoS ONE
Diagnostic and prognostic evaluation of chronic lymphocytic leukemia (CLL) involves blood cell counts, immunophenotyping, IgVH mutation status, and cytogenetic analyses. We generated B-cell associated gene-signatures (BAGS) based on six naturally occ
Autor:
David A. Frank, Klaus Koefoed, Mikkel W. Pedersen, Christian H. Geisler, Josephine L. Klitgaard, Ole V. Gadeberg, Jørgen Petersen, Jesper Jurlander
Publikováno v:
British journal of haematology. 163(2)
The treatment of chronic lymphocytic leukaemia (CLL) has been improved by introduction of monoclonal antibodies (mAbs) that exert their effect through secondary effector mechanisms. CLL cells are characterized by expression of CD5 and CD23 along with