Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Josephine Kugler"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The human aryl hydrocarbon receptor (AHR) undergoes continuous shuttling between nucleus and cytoplasm. Binding to exogenous or endogenous ligands promotes its rapid nuclear import. The proposed mechanism for the ligand-dependent import is b
Externí odkaz:
https://doaj.org/article/808bcdb72eda4287b230e39294a4c583
Autor:
Rashad Haidar, Frank Henkler, Josephine Kugler, Aline Rosin, Doris Genkinger, Peter Laux, Andreas Luch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The human aryl hydrocarbon receptor (AHR) is predominantly located in the cytoplasm, while activation depends on its nuclear translocation. Binding to endogenous or xenobiotic ligands terminates the basal nucleo-cytoplasmic shuttling and sta
Externí odkaz:
https://doaj.org/article/5c2e3168a5954908a06b6a2e92be1fac
Autor:
Peter Laux, Aline Rosin, Andreas Luch, Rashad Haidar, Josephine Kugler, Doris Genkinger, Frank Henkler
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
The human aryl hydrocarbon receptor (AHR) is predominantly located in the cytoplasm, while activation depends on its nuclear translocation. Binding to endogenous or xenobiotic ligands terminates the basal nucleo-cytoplasmic shuttling and stabilizes a
Autor:
Gilbert Schönfelder, S. Zellmer, Tewes Tralau, Andreas Hensel, Denise Bloch, S. Schmeisser, Andreas Luch, Michael Oelgeschläger, Roland Solecki, T. Burgdorf, Vera Ritz, A. Trubiroha, Albert Braeuning, Josephine Kugler, Philip Marx-Stoelting
Publikováno v:
Nature Food. 2:463-468
Many widely used chemicals result in ubiquitous human exposure from multiple sources, including diet. Legislation mainly deals with the toxicological evaluation of single substances owing to a methodological and conceptual lack of alternatives, and d
Publikováno v:
Toxicological Sciences. 152:382-394
Embryonic stem cells (ESCs) are commonly used for the analysis of gene function in embryonic development and provide valuable models for human diseases. In recent years, ESCs have also become an attractive tool for toxicological testing, in particula
Publikováno v:
Expert opinion on drug metabolismtoxicology. 13(8)
The advent of stem cell technology has seen the establishment of embryonic stem cells (ESCs) as molecular model systems and screening tools. Although ESCs are nowadays widely used in research, regulatory implementation for developmental toxicity test
Publikováno v:
Trends in pharmacological sciences. 37(10)
Despite our increasing understanding of molecular mechanisms controlling embryogenesis, the identification and characterization of teratogenic substances still heavily relies on animal testing. Embryonic development depends on cell-autonomous and non
Autor:
Julian Tharmann, Josephine Kugler, Andreas Luch, Susana M. Chuva de Sousa Lopes, Michael Oelgeschläger, Rolf Kemler
Publikováno v:
Toxicological Sciences, 146(2), 374-385
Embryonic stem cells (ESCs) were first isolated from mouse embryos more than 30 years ago. They have proven invaluable not only in generating genetically modified mice that allow for analysis of gene function in tissue development and homeostasis but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6b290ed762fba153a893d2dbb59a52
https://hdl.handle.net/1887/107355
https://hdl.handle.net/1887/107355
Autor:
Barbara Grune, Dana Sittner, Josephine Kugler, Andrea Seiler, Daniel Butzke, Andreas Luch, Michael Oelgeschläger, Manfred Liebsch
The first years of the 21 st century have seen an unparalleled progress in biomedical sciences. Several dogmata that haunted scientific debate for decades were easily abandoned, and there is a fundamental shift away from eminence-based toward evidenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::269ed7075d7ec69f5c8c5b7476c7b926
https://doi.org/10.1016/b978-0-12-415894-8.00003-8
https://doi.org/10.1016/b978-0-12-415894-8.00003-8
Autor:
Bernhard Aigner, Akira Andoh, Lina Badimon, Alexandre Benani, Ross A. Breckenridge, Daniel Butzke, Andrew V. Caprariello, Laura Casani, Lucas M. Chaible, Li Chen, Mengqi Chen, K. Yeon Choi, Mohammed Emamussalehin Choudhury, Iain J. Clarke, Kristine Coleman, John L. Daiss, Frédérique Datiche, Catherine M. Davis, Geoffrey A. Donnan, David Feifel, Peter Fickert, Marcus A. Finzi Corat, Xavier Fioramonti, Christopher H. Fry, Sharyl Fyffe-Maricich, Ann-Christin Gaupel, Steven R. Goldberg, Yoichi Gondo, Barbara Grune, Belinda A. Henry, David W. Howells, Joshua G. Hunter, Soudabeh Imanikia, Rita I. Jabr, Naoto Kadoguchi, Lixin Kan, Jiro Kasahara, Stephen L. Kates, Matthew W. Kemp, Barbara Kessler, Saeed R. Khan, Denise Kinoshita, Nikolai Klymiuk, Ryuta Koyama, Doris Kretzschmar, Josephine Kugler, Jitka Kuncova, Maki Kuro, Mayuko Kurome, Michael Lardelli, Heather A. Lawson, Edmund Chun Yu Lee, Corinne Leloup, Lars Lewejohann, Manfred Liebsch, Fabienne Lienard, James Lokensgard, Andreas Luch, Malcolm R. Macleod, Meghan E. McGee-Lawrence, Alistair McGregor, Robert H. Miller, Atsushi Mizoguchi, Sarah Mordan-McCombs, Gabrielle C. Musk, Aysegul Nalca, Masahiro Nomoto, Victoria E. O’Collins, Michael Oelgeschläger, Christoph H. Österreicher, Luc Penicaud, Marion J. Pollheimer, Simone Renner, Sara I. Ruiz, Masatoshi Saito, Scott Schachtele, Steven J. Schapiro, Charles W. Schindler, Edward M. Schwarz, Frank J. Secreto, Andrea Seiler, Angela L. Shamchuk, Richard P. Shannon, You-Tang Shen, Paul D. Shilling, Dana Sittner, Gideon P. Smith, Milan Stengl, Stephen R. Stürzenbaum, Jitka Sviglerova, Farhan A. Syed, Jerrold Tannenbaum, Martin Tenniswood, Louise Thibault, Keith B. Tierney, Michael Trauner, Airo Tsubura, Judith Axler Turner, Giuseppe Verdile, Gemma Vilahur, Wei-Lin Winnie Wang, James L. Weed, JoEllen Welsh, Steffi Werler, Joachim Wistuba, Eckhard Wolf, Annegret Wünsch, Toshiyuki Yamamoto, Hironori Yokoyama, Katsuhiko Yoshizawa, Maria L. Zaidan Dagli, Caroline J. Zeiss, Elizabeth E. Zumbrun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f8e600be6cf2585fa623d35f190cc0
https://doi.org/10.1016/b978-0-12-415894-8.01002-2
https://doi.org/10.1016/b978-0-12-415894-8.01002-2