Výsledky vyhledávání - "Josephine Jansen"

Epitope analysis of the malaria surface antigen pfs48/45 identifies a subdomain that elicits transmission blocking antibodies

Autor: Anita Kaan, Nikolay S. Outchkourov, Robert W. Sauerwein, Josephine Jansen, Li Yan Qiu, Edwin Lasonder, Adriaan M. W. Vermunt, Will Roeffen, Marga van de Vegte-Bolmer, Anneke A.M. Braks, Karina Teelen, Hendrik G. Stunnenberg

Publikováno v: Journal of Biological Chemistry, 282, 17148-56
Journal of Biological Chemistry, 282, 23, pp. 17148-56
Journal of Biological Chemistry, 282, 23, pp. 17148-17156
Journal of Biological Chemistry, 282, 17148-17156

Contains fulltext : 34792.pdf (Publisher’s version ) (Open Access) Pfs48/45, a member of a Plasmodium-specific protein family, displays conformation-dependent epitopes and is an important target for malaria transmission-blocking (TB) immunity. To d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8733260a677199f690d36433ffd78c1
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/34792

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Cloning and expression of the gene coding for the transmission blocking target antigen Pfs48/45 of Plasmodium falciparum

Autor: David C. Kaslow, Clemens H. M. Kocken, John G.G. Schoenmakers, Anita Kaan, Josephine Jansen, Pieter J. A. Beckers, Ruud N.H. Konings, T. Ponnudurai

Publikováno v: Molecular and Biochemical Parasitology. 61:59-68

The gene encoding the gametocyte/gamete-specific membrane protein Pfs48/45 of Plasmodium falciparum has been cloned. The Pfs48/45 gene is a non-interrupted, single copy gene that codes for a hydrophobic, non-repetitive protein of 448 amino acid resid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085e56461513227a917a84518cf5b34b
https://doi.org/10.1016/0166-6851(93)90158-t

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Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice

Autor: Nikolay S. Outchkourov, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Robert W. Sauerwein, Anita Kaan, Hendrik G. Stunnenberg, Will Roeffen, Adrian J. F. Luty, Danielle Schuiffel, Josephine Jansen

Publikováno v: Proceedings of the National Academy of Sciences USA, 105, 11, pp. 4301-4305
Proceedings of the National Academy of Sciences USA, 105, 4301-4305

Malaria kills >1 million people each year, in particular in sub-Saharan Africa. Although asexual forms are directly responsible for disease and death, sexual stages account for the transmission of Plasmodium parasites from human to the mosquito vecto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5515dcc82d74f76d83330684be7a6cbf
https://hdl.handle.net/2066/70724

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Immunological properties of recombinant proteins of the transmission blocking vaccine candidate, Pfs48/45, of the human malaria parasite Plasmodium falciparum produced in Escherichia coli

Autor: Ruud N.H. Konings, Will Roeffen, Josephine Jansen, Clemens H. M. Kocken, Richard L.B. Milek, Anita Kaan, Robert W. Sauerwein, Wijnand Eling

Publikováno v: Parasite Immunology, 20, pp. 377-385
Parasite Immunology, 20, 377-385

A precondition for the development of a transmission blocking vaccine based on the sexual stage-specific surface antigen Pfs48/45 of Plasmodium falciparum is its heterologous synthesis in a native state. Here we describe the production of recombinant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34807942398ce70f1db70dc40d6ff5a6
https://hdl.handle.net/2066/224535

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Stage-specific expression and genomic organization of the actin genes of the malaria parasite Plasmodium falciparum

Autor: Peter J.F. Snijders, Mari A. Smits, John G. Wesseling, John G.G. Schoenmakers, Petri van Someren, Josephine Jansen

Publikováno v: Molecular and Biochemical Parasitology. 35:167-176

Two different actin transcripts are found in the human malaria parasite Plasmodium falciparum. One of these is a 2.5-kb-long RNA found both in asexual blood stages and in the sexual stages (i.e., gametes/zygotes) of the parasite. This transcript is e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ea0d4ba56bc68937f6f006a4f00b34
https://doi.org/10.1016/0166-6851(89)90119-9

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Synthesis of Bacteriophage M13-Specific Proteins in a DNA-Dependent Cell-Free System II. In Vitro Synthesis of Biologically Active Gene 5 Protein

Autor: John G.G. Schoenmakers, Josephine Jansen, Ruud N.H. Konings, Theo Cuypers

Publikováno v: Journal of Virology. 12:1466-1472

It is shown that gene 5 protein of bacteriophage M13 is one of the major proteins synthesized in vitro under the direction of M13 replicative-form DNA. By means of DNA-cellulose chromatography, this protein has been purified to homogeneity and its bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa96282324362174f3e23e8c4fd9064
https://doi.org/10.1128/jvi.12.6.1466-1472.1973

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Initiation and termination signals for transcription in bacteriophage M13

Autor: John G.G. Schoenmakers, Mari A. Smits, Ruud N.H. Konings, Josephine Jansen

Publikováno v: Nucleic acids research. 12(10)

Transcription of the infrequently expressed phage M13 genome domain, comprising genes III, VI, I and IV, has been studied in detail by hybridization and S1-nuclease mapping studies. The contiguous genes III and VI are transcribed via an 1800 nucleoti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3122045c7f96cdf97e76970c03842a1f
https://pubmed.ncbi.nlm.nih.gov/6328409

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