Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Josephine Incardona"'
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:619-626
Epigallocatechin-3-gallate (EGCG) is the major catechin found in green tea. EGCG is also available for consumption in the form of concentrated over-the-counter nutritional supplements. This compound is currently undergoing clinical trials for the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60effcc8aed313a6ff79b4d485a18f5
https://doi.org/10.1124/jpet.110.169391
https://doi.org/10.1124/jpet.110.169391
Autor:
Josephine Incardona, Hsien C. Cheng
Publikováno v:
Journal of pharmacological and toxicological methods. 60(2)
Introduction For studying the torsades de pointes (TdP) liability of a compound, most high and medium throughput methods use surrogate markers such as HERG inhibition and QT prolongation. In this study, we have tested whether isolated hearts may be m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062d75504e177b9ff05c3f3a2a124a78
https://pubmed.ncbi.nlm.nih.gov/19524054
https://pubmed.ncbi.nlm.nih.gov/19524054
Publikováno v:
Journal of pharmacological and toxicological methods. 54(3)
Introduction One of the biomarkers for assessing the risk of a cardiac adverse event is drug-induced prolongation of the QT interval. A model is needed for evaluating the potential liability of test compounds on QT interval in vitro. Since QT interva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9939ead6906c86570c3c276b366331ff
https://pubmed.ncbi.nlm.nih.gov/16507347
https://pubmed.ncbi.nlm.nih.gov/16507347
Autor:
Hongge Wang, Michel Tabart, David Rampe, Jiesheng Kang, Josephine Incardona, Hsien Cheng, Junzhi Ji, William P. Reynolds, Fabrice Viviani, Xiao-Liang Chen
Publikováno v:
Molecular pharmacology. 67(3)
Many drugs inhibit the human ether-a-go-go-related gene (HERG) cardiac K+ channel. This leads to action potential prolongation on the cellular level, a prolongation of the QT interval on the electrocardiogram, and sometimes cardiac arrhythmia. To dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff865a028fcb9860f301903fa2dae790
https://pubmed.ncbi.nlm.nih.gov/15608141
https://pubmed.ncbi.nlm.nih.gov/15608141
Autor:
Hsien C. Cheng, Josephine Incardona
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 60:241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e47a0b94c99e715afed5cfb97ad14276
https://doi.org/10.1016/j.vascn.2009.04.133
https://doi.org/10.1016/j.vascn.2009.04.133