Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Josephine Iaria"'
Autor:
Kaiseal T. G. Sarson-Lawrence, Joshua M. Hardy, Josephine Iaria, Dina Stockwell, Kira Behrens, Tamanna Saiyed, Cyrus Tan, Leila Jebeli, Nichollas E. Scott, Toby A. Dite, Nicos A. Nicola, Andrew P. Leis, Jeffrey J. Babon, Nadia J. Kershaw
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Thrombopoietin (Tpo) is the primary regulator of megakaryocyte and platelet numbers and is required for haematopoetic stem cell maintenance. Tpo functions by binding its receptor (TpoR, a homodimeric Class I cytokine receptor) and initiating
Externí odkaz:
https://doaj.org/article/90ff36cf97bf40a595fd54f4fb808af6
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Metastasis is the leading cause of cancer-related deaths. Transforming growth factor beta (TGF-β) signaling drives metastasis and is strongly enhanced during cancer progression. Yet, the use of on-target TGF-β signaling inhibitors in the t
Externí odkaz:
https://doaj.org/article/9bb0f02efb034e0c9c89d7c9a48e9cec
Publikováno v:
Cells, Vol 13, Iss 14, p 1166 (2024)
Background: Metastasis is the main cause of cancer-related deaths, but efficient targeted therapies against metastasis are still missing. Major gaps exist in our understanding of the metastatic cascade, as existing methods cannot combine sensitivity,
Externí odkaz:
https://doaj.org/article/508049fc46d845b7a709d241b442136f
Autor:
Jiang Ren, Marcel Smid, Josephine Iaria, Daniela C. F. Salvatori, Hans van Dam, Hong Jian Zhu, John W. M. Martens, Peter ten Dijke
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-19 (2019)
Abstract Background Bone morphogenetic proteins (BMPs) have been reported to maintain epithelial integrity and to antagonize the transforming growth factor β (TGFβ)-induced epithelial to mesenchymal transition. The expression of soluble BMP antagon
Externí odkaz:
https://doaj.org/article/50a06274665c41f1aafa3ffd1fad1d73
Publikováno v:
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-15 (2018)
Abstract Background Transformation by oncogene Ras overcomes TGF-β mediated growth inhibition in epithelial cells. However, it cooperates with each other to mediate epithelial to mesenchymal transition (EMT). The mechanism of how these two pathways
Externí odkaz:
https://doaj.org/article/2bffa39f269c46e2a9e294dc7da6847b
Publikováno v:
Cancer Letters, 493, 41-54. ELSEVIER IRELAND LTD
TGF beta-SMAD3 signaling is a major driving force for cancer metastasis, while BMP-SMAD1/5 signaling can counteract this response. Analysis of gene expression profiles revealed that an increased TGF beta-SMAD3 and a reduced BMP-SMAD1/5 targeted gene
Autor:
John W.M. Martens, Josephine Iaria, Marcel Smid, Peter ten Dijke, Daniela C.F. Salvatori, Jiang Ren, Hong-Jian Zhu, Hans van Dam
Publikováno v:
Breast Cancer Research, 21(1)
Breast Cancer Research : BCR
Breast Cancer Research, Vol 21, Iss 1, Pp 1-19 (2019)
Breast Cancer Research, 21(1):109. BioMed Central Ltd.
Breast Cancer Research
Breast Cancer Research : BCR
Breast Cancer Research, Vol 21, Iss 1, Pp 1-19 (2019)
Breast Cancer Research, 21(1):109. BioMed Central Ltd.
Breast Cancer Research
Background Bone morphogenetic proteins (BMPs) have been reported to maintain epithelial integrity and to antagonize the transforming growth factor β (TGFβ)-induced epithelial to mesenchymal transition. The expression of soluble BMP antagonists is d
Publikováno v:
J Vis Exp
Transforming Growth Factor β (TGF-β) signaling regulates many important functions required for cellular homeostasis and is commonly found overexpressed in many diseases, including cancer. TGF-β is strongly implicated in metastasis during late stag
Publikováno v:
Journal of Visualized Experiments.
Transforming Growth Factor β (TGF-β) signaling regulates many important functions required for cellular homeostasis and is commonly found overexpressed in many diseases, including cancer. TGF-β is strongly implicated in metastasis during late stag
Publikováno v:
Growth Factors. 21:15-30
The epidermal growth factor receptor (EGFR) plays an important role in many types of human cancers. Receptor amplification, autocrine activation and/or deletion of exons 2-7 of EGFR gene have all been associated with tumor development. The traditiona