Zobrazeno 1 - 9
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pro vyhledávání: '"Josephine H. Leung"'
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Nicotinamide nucleotide transhydrogenase (TH) is an enzyme complex in animal mitochondria and bacteria that utilizes the electrochemical proton gradient across membranes to drive the production of NADPH. The enzyme plays an important role in maintain
Externí odkaz:
https://doaj.org/article/3fb0b4036c8948918017b7c55e64263f
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Frontiers in Physiology
Frontiers in Physiology
Nicotinamide nucleotide transhydrogenase (TH) is an enzyme complex in animal mitochondria and bacteria that utilizes the electrochemical proton gradient across membranes to drive the production of NADPH. The enzyme plays an important role in maintain
Autor:
Robert B. Gennis, Sangjin Hong, Pius S. Padyatti, Paween Mahinthichichan, Josephine H. Leung, Lici A. Schurig-Briccio, Chang Sun
Publikováno v:
Mechanisms of Primary Energy Transduction in Biology ISBN: 9781782628651
The membrane-bound nicotinamide nucleotide transhydrogenase is a key enzyme for the maintenance of metabolic balance in mammalian cells as well as in many bacteria. The enzyme resides in the mitochondrial inner membrane in eukaryotic cells or the cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1691102720514d641c99a33878fe65b1
https://doi.org/10.1039/9781788010405-00104
https://doi.org/10.1039/9781788010405-00104
Publikováno v:
FEBS Letters. 589:2027-2033
The membrane protein transhydrogenase in animal mitochondria and bacteria couples reduction of NADP+ by NADH to proton translocation. Recent X-ray data on Thermus thermophilus transhydrogenase indicate a significant difference in the orientations of
Autor:
Josephine H. Leung, Jeffrey A. Speir, Lici A. Schurig-Briccio, Mutsuo Yamaguchi, C.D. Stout, Robert B. Gennis, Arne Moeller
Publikováno v:
Science (New York, N.Y.). 347(6218)
Dueling dimers serve dual purposes Both bacteria and mitochrondria produce NADPH for amino acid biosynthesis and to remove reactive oxygen species. The enzyme that makes NADPH must translocate a proton across the membrane and transfer a hydride from
Autor:
Jennifer H. Dufour, Josephine H. Leung, Thomas E. Lane, Michael T. Liu, Michelle Dziejman, Andrew D. Luster
Publikováno v:
The Journal of Immunology. 168:3195-3204
IFN-γ-inducible protein 10 (IP-10, CXCL10), a chemokine secreted from cells stimulated with type I and II IFNs and LPS, is a chemoattractant for activated T cells. Expression of IP-10 is seen in many Th1-type inflammatory diseases, where it is thoug
Autor:
C. David Stout, Robert B. Gennis, Pius S. Padayatti, J. Baz Jackson, Qinghai Zhang, Josephine H. Leung, S. Michael Soltis, Paween Mahinthichaichan, Andrii Ishchenko, Vadim Cherezov, Emad Tajkhorshid
Publikováno v:
Structure. 25:1111-1119.e3
Summary The nicotinamide nucleotide transhydrogenase (TH) is an integral membrane enzyme that uses the proton-motive force to drive hydride transfer from NADH to NADP + in bacteria and eukaryotes. Here we solved a 2.2-A crystal structure of the TH tr
Autor:
Jorge Plutzky, Nikolaus Marx, Alain Sauty, Josephine H. Leung, François Mach, Mindy N. Sarafi, Richard M. Ransohoff, Peter Libby, Andrew D. Luster
Publikováno v:
The Journal of Immunology. 164:6503-6508
Peroxisome proliferator-activated receptor-γ (PPARγ), a member of the nuclear hormone receptor superfamily originally shown to play an important role in adipocyte differentiation and glucose homeostasis, is now known to regulate inflammatory respon
Autor:
Michelle Toft, Joseph El Khoury, Kinya Terada, Kathryn J. Moore, Mason W. Freeman, Terry K. Means, Josephine H. Leung, Andrew D. Luster
Publikováno v:
The Journal of Experimental Medicine
Accumulation of inflammatory microglia in Alzheimer's senile plaques is a hallmark of the innate response to beta-amyloid fibrils and can initiate and propagate neurodegeneration characteristic of Alzheimer's disease (AD). The molecular mechanism whe