Zobrazeno 1 - 10 of 72 pro vyhledávání: '"Josephine F Trott"'
1
Akademický článek
Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent.
Autor: Jane Q Chen, Hidetoshi Mori, Robert D Cardiff, Josephine F Trott, Russell C Hovey, Neil E Hubbard, Jesse A Engelberg, Clifford G Tepper, Brandon J Willis, Imran H Khan, Resmi K Ravindran, Szeman R Chan, Robert D Schreiber, Alexander D Borowsky
Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129895 (2015)
Female 129:Stat1-null mice (129S6/SvEvTac-Stat1(tm1Rds) homozygous) uniquely develop estrogen-receptor (ER)-positive mammary tumors. Herein we report that the mammary glands (MG) of these mice have altered growth and development with abnormal termina
Externí odkaz: https://doaj.org/article/29929a32a62840c7829521206f08d497
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2
Akademický článek
Transcriptomic changes underlying glucocorticoid-induced suppression of milk production by dairy cows
Autor: Anna Sadovnikova, Sergio C. Garcia, Josephine F. Trott, Alice T. Mathews, Monica T. Britton, Blythe P. Durbin-Johnson, Russell C. Hovey
Publikováno v: Frontiers in Genetics, Vol 13 (2022)
Milk production by dairy cows is sensitive to increased levels of stress hormones such as glucocorticoids (GC) that also regulate the transcription of several genes required for milk synthesis. Whereas previous studies identified that an exogenous GC
Externí odkaz: https://doaj.org/article/522cd36bf7374731a84e7230c2121681
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3
Akademický článek
One-step generation of a targeted knock-in calf using the CRISPR-Cas9 system in bovine zygotes
Autor: Joseph R. Owen, Sadie L. Hennig, Bret R. McNabb, Tamer A. Mansour, Justin M. Smith, Jason C. Lin, Amy E. Young, Josephine F. Trott, James D. Murray, Mary E. Delany, Pablo J. Ross, Alison L. Van Eenennaam
Publikováno v: BMC Genomics, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background The homologous recombination (HR) pathway is largely inactive in early embryos prior to the first cell division, making it difficult to achieve targeted gene knock-ins. The homology-mediated end joining (HMEJ)-based strategy has b
Externí odkaz: https://doaj.org/article/8631b0fe8f854c6b809a56145bbc2a7d
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5
Akademický článek
Pathobiology of the 129:Stat1 −/− mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype
Autor: Hidetoshi Mori, Jane Q. Chen, Robert D. Cardiff, Zsófia Pénzváltó, Neil E. Hubbard, Louis Schuetter, Russell C. Hovey, Josephine F. Trott, Alexander D. Borowsky
Publikováno v: Breast Cancer Research, Vol 19, Iss 1, Pp 1-18 (2017)
Abstract Background Stat1 gene-targeted knockout mice (129S6/SvEvTac-Stat1 tm1Rds) develop estrogen receptor-positive (ER+), luminal-type mammary carcinomas at an advanced age. There is evidence for both host environment as well as tumor cell-intrins
Externí odkaz: https://doaj.org/article/45215435b0f24753a764f145235b39fa
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10
In Utero Exposure to trans-10, cis-12 Conjugated Linoleic Acid Modifies Postnatal Development of the Mammary Gland and its Hormone Responsiveness
Autor: Grace E. Berryhill, Russell C. Hovey, Josephine F. Trott, Adam L. Lock, Jana Kraft, Julia M Gloviczki
Publikováno v: Journal of mammary gland biology and neoplasia, vol 26, iss 3
Journal of Mammary Gland Biology and Neoplasia
We previously showed that dietary trans-10, cis-12 conjugated linoleic acid (10,12 CLA) stimulates estrogen-independent mammary growth in young ovariectomized mice. Here we investigated the effects of in utero or postnatal exposure to cis-9, trans-11
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa28e767c1a358d811aeb4fa3590221
https://doi.org/10.1007/s10911-021-09499-y
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