Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Josephine F Reijneveld"'
Autor:
Victor E Nieto-Caballero, Josephine F Reijneveld, Angel Ruvalcaba, Gabriel Innocenzi, Nalin Abeydeera, Samira Asgari, Kattya Lopez, Sarah K Iwany, Yang Luo, Aparna Nathan, Daniela Fernandez-Salinas, Marcos Chiñas, Chuan-Chin Huang, Zibiao Zhang, Segundo R León, Roger I Calderon, Leonid Lecca, Jonathan M Budzik, Megan Murray, Ildiko Van Rhijn, Soumya Raychaudhuri, D Branch Moody, Sara Suliman, Maria Gutierrez-Arcelus
Publikováno v:
PLoS Genetics, Vol 20, Iss 6, p e1011313 (2024)
A quarter of humanity is estimated to have been exposed to Mycobacterium tuberculosis (Mtb) with a 5-10% risk of developing tuberculosis (TB) disease. Variability in responses to Mtb infection could be due to host or pathogen heterogeneity. Here, we
Externí odkaz:
https://doaj.org/article/09b9308f2de04ddead6207cc42be5dd7
Autor:
Marcin Wegrecki, Tonatiuh A. Ocampo, Sachith D. Gunasinghe, Anouk von Borstel, Shin Yi Tin, Josephine F. Reijneveld, Thinh-Phat Cao, Benjamin S. Gully, Jérôme Le Nours, D. Branch Moody, Ildiko Van Rhijn, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
T cell receptors are generally thought to contact antigens presented in an end to end configuration. Here the authors show a geometrically alternate sideways mode of recognition of the antigen-presenting molecule CD1a by a γδ T cell receptor.
Externí odkaz:
https://doaj.org/article/a5eb21242f424541a6a488c362e95bcb
Autor:
Josephine F. Reijneveld, Mira Holzheimer, David C. Young, Kattya Lopez, Sara Suliman, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B. Murray, Eri Ishikawa, Sho Yamasaki, Adriaan J. Minnaard, D. Branch Moody, Ildiko Van Rhijn
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized thr
Externí odkaz:
https://doaj.org/article/90220270f20747fdaf524d58aa1ac4a7
Autor:
Adam Shahine, Peter Reinink, Josephine F. Reijneveld, Stephanie Gras, Mira Holzheimer, Tan-Yun Cheng, Adriaan J. Minnaard, John D. Altman, Steffi Lenz, Jacques Prandi, Joanna Kubler-Kielb, D. Branch Moody, Jamie Rossjohn, Ildiko Van Rhijn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derive
Externí odkaz:
https://doaj.org/article/8b688ab776554395acd758b05b541c3e
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Granzyme A (GrA) has long been recognized as one of the key players in the induction of cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells. While the cytotoxic potential of GrA is controversial in current li
Externí odkaz:
https://doaj.org/article/3f5654d101f347e3b52042dbc3a0037f
Autor:
Kattya Lopez, Sarah K. Iwany, Sara Suliman, Josephine F. Reijneveld, Tonatiuh A. Ocampo, Judith Jimenez, Roger Calderon, Leonid Lecca, Megan B. Murray, D. Branch Moody, Ildiko Van Rhijn
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The non-polymorphic nature of CD1 proteins creates a situation in which T cells with invariant T cell receptors (TCRs), like CD1d-specific NKT cells, are present in all humans. CD1b is an abundant protein on human dendritic cells that presents M. tub
Externí odkaz:
https://doaj.org/article/e77bf81c33654c23b5d3fef91290210f
Autor:
Tonatiuh A. Ocampo, Adrian Hayday, Adam Shahine, Jamie Rossjohn, Benjamin S. Gully, Pierre Vantourout, D. Branch Moody, Ildiko Van Rhijn, Josephine F. Reijneveld
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22944-22952. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22944. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22944. National Academy of Sciences
γδ T cells form an abundant part of the human cellular immune system, where they respond to tissue damage, infection, and cancer. The spectrum of known molecular targets recognized by Vδ1-expressing γδ T cells is becoming increasingly diverse. H
Autor:
Georgios Misiakos, Ildiko Van Rhijn, David C. Young, D. Branch Moody, Mira Holzheimer, Adriaan J. Minnaard, Alexandrea K. Ramnarine, Eri Ishikawa, Tan-Yun Cheng, Sho Yamasaki, Josephine F. Reijneveld
Publikováno v:
ACS chemical biology, 15(7), 1835-1841. AMER CHEMICAL SOC
ACS Chemical Biology
ACS Chemical Biology
The first asymmetric total synthesis of three structures proposed for mycobacterial diacyl trehaloses, DAT1, DAT2, and DAT3 is reported. The presence of two of these glycolipids, DAT1 and DAT3, within different strains of pathogenic M. tuberculosis w
Autor:
Gijsbert A. van der Marel, Dennis Dam, Laura Marino, Jamie Rossjohn, D. Branch Moody, Jeroen D. C. Codée, Tan-Yun Cheng, Ildiko Van Rhijn, Thinh-Phat Cao, Josephine F. Reijneveld, Martin D. Witte, Dmitri V. Filippov, Adriaan J. Minnaard, Adam Shahine, Sara Suliman
Publikováno v:
Journal of Biological Chemistry, 297(4)
Journal of Biological Chemistry, 297(4), 1. American Society for Biochemistry and Molecular Biology Inc.
The Journal of Biological Chemistry
Journal of Biological Chemistry, 297(4):101197. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of Biological Chemistry, 297(4), 1. American Society for Biochemistry and Molecular Biology Inc.
The Journal of Biological Chemistry
Journal of Biological Chemistry, 297(4):101197. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Whereas proteolytic cleavage is crucial for peptide presentation by classical major histocompatibility complex (MHC) proteins to T cells, glycolipids presented by CD1 molecules are typically presented in an unmodified form. However, the mycobacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d1fe6f3f452d6963f984cd927cb195
Autor:
David C. Young, Leonid Lecca, Judith Jimenez, Josephine F. Reijneveld, Roger Calderon, D. Branch Moody, Sara Suliman, Mira Holzheimer, Adriaan J. Minnaard, Megan Murray, Ildiko Van Rhijn, Sho Yamasaki, Eri Ishikawa, Kattya Lopez
Publikováno v:
Scientific Reports
Scientific Reports, 11(1):2010. Nature Publishing Group
Scientific Reports, 11(1), 1. NLM (Medline)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, 11(1):2010. Nature Publishing Group
Scientific Reports, 11(1), 1. NLM (Medline)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms