Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Josephine E. E. U. Hellberg"'
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Soil bacteria can be prolific producers of secondary metabolites and other biologically active compounds of economic and clinical importance. These natural products are often synthesised by large multi-enzyme complexes such as polyketide synthases (P
Externí odkaz:
https://doaj.org/article/f80d280b006d4c71a3666c7cd884e702
Autor:
Aashika Sekar, Aaron Leiblich, S Mark Wainwright, Cláudia C Mendes, Dhruv Sarma, Josephine E E U Hellberg, Carina Gandy, Deborah C I Goberdhan, Freddie C Hamdy, Clive Wilson
Publikováno v:
PLoS Genetics, Vol 19, Iss 6, p e1010815 (2023)
In prostate cancer, loss of the tumour suppressor gene, Retinoblastoma (Rb), and consequent activation of transcription factor E2F1 typically occurs at a late-stage of tumour progression. It appears to regulate a switch to an androgen-independent for
Externí odkaz:
https://doaj.org/article/bba9b34ae61a425293f1b4d2428048d7
Autor:
Aaron Leiblich, Josephine E E U Hellberg, Aashika Sekar, Carina Gandy, Claudia C Mendes, Siamak Redhai, John Mason, Mark Wainwright, Pauline Marie, Deborah C I Goberdhan, Freddie C Hamdy, Clive Wilson
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000145 (2019)
Male reproductive glands like the mammalian prostate and the paired Drosophila melanogaster accessory glands secrete seminal fluid components that enhance fecundity. In humans, the prostate, stimulated by environmentally regulated endocrine and local
Externí odkaz:
https://doaj.org/article/d282914d9b1345bcb8a8f49206fdf220
Autor:
Carina Gandy, Deborah C.I. Goberdhan, Freddie C. Hamdy, Sekar A, Sarma D, Josephine E. E. U. Hellberg, Cláudia C. Mendes, Aaron Leiblich, Clive Wilson, S M Wainwright
Dysregulation of cell cycle components results in the development and progression of several cancer types. Unusually, loss of the tumour suppressor gene,Retinoblastoma(Rb), and consequent activation of transcription factor E2F1 have been linked to la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8d53281b9416c2f8c7d524df2d1038f
https://doi.org/10.1101/2021.03.27.437310
https://doi.org/10.1101/2021.03.27.437310
Autor:
Pauline P. Marie, John F. Morris, Deborah C.I. Goberdhan, S. Mark Wainwright, Aaron Leiblich, Laura Corrigan, Rachel Patel, Stuart Wigby, Abigail Pavey, Benjamin Kroeger, Sekar A, Cláudia C. Mendes, Carina Gandy, Shih-Jung Fan, Josephine E. E. U. Hellberg, Clive Wilson
Seminal fluid plays an essential role in promoting male reproductive success and modulating female physiology and behaviour. In the fruit fly,Drosophila melanogaster, Sex Peptide (SP) is the best-characterised protein mediator of these effects. It is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa31aca515eb1e59ed31ec998a23953
https://doi.org/10.1101/2020.04.24.059238
https://doi.org/10.1101/2020.04.24.059238
Autor:
John Mason, Mark Wainwright, Aaron Leiblich, Clive Wilson, Freddie C. Hamdy, Deborah C.I. Goberdhan, Cláudia C. Mendes, Josephine E. E. U. Hellberg, Carina Gandy, Pauline P. Marie, Sekar A, Siamak Redhai
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 10, p e3000145 (2019)
PLoS Biology, Vol 17, Iss 10, p e3000145 (2019)
Male reproductive glands like the mammalian prostate and the paired Drosophila melanogaster accessory glands secrete seminal fluid components that enhance fecundity. In humans, the prostate, stimulated by environmentally regulated endocrine and local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac23f7f01ccf7d8277484e710e61655
https://doi.org/10.1371/journal.pbio.3000145
https://doi.org/10.1371/journal.pbio.3000145
Autor:
Josephine E. E. U. Hellberg, Zhizhou Zhang, Yuan Zhao, Trin Athigapanich, Max J. Telford, Ann F. Gilliat, Johannes Girstmair, Alexandre Benedetto, Marina Ezcurra, David Gems, Hongyuan Wang
Many diseases whose frequency increases with advancing age are caused by aging (senescence), but the mechanisms of senescence remain poorly understood. According to G.C. Williams and M.V. Blagosklonny, a major etiological determinant of senescence is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758179689feccc638e9d62c9b28aa532
Autor:
Siamak Redhai, Josephine E E U Hellberg, Mark Wainwright, Sumeth W Perera, Felix Castellanos, Benjamin Kroeger, Carina Gandy, Aaron Leiblich, Laura Corrigan, Thomas Hilton, Benjamin Patel, Shih-Jung Fan, Freddie Hamdy, Deborah C I Goberdhan, Clive Wilson
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 10, p e1006366 (2016)
PLoS Genetics, Vol 12, Iss 10, p e1006366 (2016)
Regulated secretion by glands and neurons involves release of signalling molecules and enzymes selectively concentrated in dense-core granules (DCGs). Although we understand how many secretagogues stimulate DCG release, how DCG biogenesis is then acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a19cf265abc4ef13dc779553c9e39d23
https://pubmed.ncbi.nlm.nih.gov/27727275
https://pubmed.ncbi.nlm.nih.gov/27727275
Autor:
Francesc Xavier Marsellach, Bartlomiej Tomiczek, Jared T. Simpson, Tobias Mourier, Francois Balloux, Kirsten McLay, Jürg Bähler, Sophie R. Atkinson, Daniel C. Jeffares, Theodora C. Sideri, Charalampos Rallis, Laurent van Trigt, Nikolas Maniatis, Melanie Febrer, Zamin Iqbal, Josephine E. E. U. Hellberg, Adrien Rieux, Richard Durbin, Tammy M. K. Cheng, William Brown, Rodrigo Pracana, Malte Thodberg, Anatole Chessel, Doug Speed, Leanne Bischof, Martin Převorovský, David J. Balding, Michael Mülleder, Danny A. Bitton, Markus Ralser, Rafael E. Carazo Salas, Brendan D. O'Fallon, Jacqueline Hayles, Sendu Bala, Nizar Drou, Linda Jeffery, Winston Lau, Jonathan L.D. Lawson, Garrett Hellenthal, Thomas M. Keane, Juan Juan Li, Sandra Codlin
Natural variation within species reveals aspects of genome evolution and function. The fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but researchers typically use one standard laboratory strain. To extend the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6118920ce00bcdf04001258881b20472
https://europepmc.org/articles/PMC4645456/
https://europepmc.org/articles/PMC4645456/
Autor:
Josephine E. E. U. Hellberg, Marina Ezcurra, Catherine Au, Jennifer M. A. Tullet, David Gems, Matthias Ziehm, Nattaphong Rattanavirotkul, Inna Feyst, Irene Papatheodorou, Ann F. Gilliat, Michele Riesen, Janet M. Thornton
Publikováno v:
Europe PubMed Central
Aging (Albany NY)
Scopus-Elsevier
Aging (Albany NY)
Scopus-Elsevier
In C. elegans, increased lifespan in daf‐2 insulin/IGF‐1 receptor mutants is accompanied by up‐regulation of the MDL‐1 Mad basic helix‐loop‐helix leucine zipper transcription factor. Here we describe the role of mdl‐1 in C. elegans germ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1979c1c067de2ccb9207ec85b45a2f8
http://europepmc.org/abstract/med/24531613
http://europepmc.org/abstract/med/24531613