Výsledky vyhledávání - "Josephine Blersch"

Induced pluripotent stem cell-derived vascular networks to screen nano–bio interactions

Autor: Helena Vazão, Vitor Francisco, Lino Ferreira, Patrícia R. Pitrez, Lara Carvalho, Akhilesh Rai, Josephine Blersch, Leonor Saúde, Mário Grãos, Inês Honório, Luís M.B.B. Estronca, Xavier Nissan, Ulrich Simon

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

© The Royal Society of Chemistry, 2021. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
The vascular bioactivity/safety of nanomaterials is typically evaluated by animal testing, which is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fe63c3b94befa39bad38587999f377
https://doi.org/10.1039/d0nh00550a

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A light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1α (HIF-1α)

Autor: Susana Simões, Lino Ferreira, Vitor Francisco, Akhilesh Rai, Catarina Rebelo, Sandra Pinto, Adrian Jiménez-Balsa, Helena Antunes, Josephine Blersch

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nanoscale

The control of vascular remodeling mediated by transcription factor HIF-1α is critical in the treatment of several diseases including cancer, retinopathies, chronic wounds, and ischemic heart disease, among others. Gene silencing using a small inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48f4388811d815aa218da451af09fe7
https://hdl.handle.net/10316/92380

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A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies

Autor: Vitor Francisco, Josephine Blersch, Hugo Fernandes, Lino Ferreira, Catarina Rebelo, Artur Filipe Rodrigues

Publikováno v: Methods
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
CIÊNCIAVITAE

RNA-based therapies are highly selective and powerful regulators of biological functions. Non-viral vectors such as nanoparticles (NPs) are very promising formulations for the delivery of RNA-based therapies but their cell targeting, cell internaliza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02913e38311bfbd02c8fda21b134186c

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A light-triggerable nanoparticle library for the controlled release of non-coding RNAs

Autor: Sandra Pinto, Adrian Jiménez-Balsa, Catarina Rebelo, Carlo Gonzato, Helena Antunes, Vitor Francisco, Susana Simões, Klaus R. Liedl, Lino Ferreira, Josephine Blersch, Karsten Haupt

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (5), pp.1985-1991. ⟨10.1002/anie.201911398⟩

RNA-based therapies offer a wide range of therapeutic interventions including for the treatment of skin diseases; however, the strategies to deliver efficiently these biomolecules are still limited due to obstacles related to the cellular uptake and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d80d67ec6635e3c6f7286645a10867f

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Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential

Autor: Rodrigo A. Cunha, Michela Comune, Kiran Kumar Chereddy, Lino Ferreira, Juan Lerma, Akhilesh Rai, Ricardo Rodrigues, Véronique Préat, Sezin Aday, Pedro N. Simões, Sandra Pinto, André F. Ferreira, Alessandra Zonari, Josephine Blersch

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Journal of Controlled Release

Chronic skin wounds affect ≈ 3% of persons aged > 60 years (Davies et al., 2007) [1]. These wounds are typically difficult to heal by conventional therapies and in many cases they get infected making even harder the regeneration process. The antimi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1006ff5dfadf469b34a6e71264e5138
https://pubmed.ncbi.nlm.nih.gov/28694030

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