Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Josephat M. Asiago"'
Autor:
Daniel Ysselstein, Mehul Joshi, Vartika Mishra, Amy M. Griggs, Josephat M. Asiago, George P. McCabe, Lia A. Stanciu, Carol Beth Post, Jean-Christophe Rochet
Publikováno v:
Neurobiology of Disease, Vol 79, Iss , Pp 150-163 (2015)
The post-mortem brains of individuals with Parkinson's disease (PD) and other synucleinopathy disorders are characterized by the presence of aggregated forms of the presynaptic protein α-synuclein (aSyn). Understanding the molecular mechanism of aSy
Externí odkaz:
https://doaj.org/article/99bd0c3cd7124b7b823323d5ca817691
Autor:
Alexey V Krasnoslobodtsev, Jie Peng, Josephat M Asiago, Jagadish Hindupur, Jean-Christophe Rochet, Yuri L Lyubchenko
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38099 (2012)
Alpha-synuclein (α-Syn) is a 140 aa presynaptic protein which belongs to a group of natively unfolded proteins that are unstructured in aqueous solutions. The aggregation rate of α-Syn is accelerated in the presence of physiological levels of cellu
Externí odkaz:
https://doaj.org/article/63684dba33494352867812e1cb35e2dc
Autor:
Tony R. Hazbun, Jean-Christophe Rochet, Lake N. Paul, Holli M. Drendel, Kiran Aslam, Kourtney M. Goode, Chai-jui Tsai, Josephat M. Asiago
Publikováno v:
Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications
The Saccharomyces cerevisiae heat shock protein Hsp31 is a stress-inducible homodimeric protein that is involved in diauxic shift reprogramming and has glyoxalase activity. We show that substoichiometric concentrations of Hsp31 can abrogate aggregati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b378e5311ce0a0383b1d5d0dbd36e60
https://doi.org/10.1074/jbc.m115.678367
https://doi.org/10.1074/jbc.m115.678367
Autor:
George P. McCabe, Daniel Ysselstein, Mehul Joshi, Jean-Christophe Rochet, Josephat M. Asiago, Lia Stanciu, Vartika Mishra, Carol Beth Post, Amy M. Griggs
Publikováno v:
Neurobiology of Disease, Vol 79, Iss, Pp 150-163 (2015)
The post-mortem brains of individuals with Parkinson’s disease (PD) and other synucleinopathy disorders are characterized by the presence of aggregated forms of the presynaptic protein α-synuclein (aSyn). Understanding the molecular mechanism of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1115451d4c71a41d2a788e6c56d84f
http://www.sciencedirect.com/science/article/pii/S0969996115001540
http://www.sciencedirect.com/science/article/pii/S0969996115001540
Autor:
Aurélie de Rus Jacquet, Trevor B. Doyle, Vartika Mishra, Jean-Christophe Rochet, Josephat M. Asiago
Publikováno v:
Oxidative Stress and Redox Signalling in Parkinson’s Disease ISBN: 9781782621881
Parkinson’s disease (PD) is a complex neurodegenerative disorder that involves a constellation of motor and nonmotor symptoms. Although several medications are moderately effective in attenuating motor symptoms during the early stages of PD, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eab464ab6b961c36b675cb05bddc4724
https://doi.org/10.1039/9781782622888-00325
https://doi.org/10.1039/9781782622888-00325
Autor:
Jean-Christophe Rochet, Ivan L. Volkov, Yuri L. Lyubchenko, Josephat M. Asiago, Jagadish Hindupur, Alexey V. Krasnoslobodtsev
Publikováno v:
Biochemistry. 52(42)
Misfolding and subsequent aggregation of alpha-synuclein (α-Syn) protein are critically involved in the development of several neurodegenerative diseases, including Parkinson’s disease (PD). Three familial single point mutations, A30P, E46K, and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1387cd75aea7d68e5304a3d8e5a018
https://pubmed.ncbi.nlm.nih.gov/24066883
https://pubmed.ncbi.nlm.nih.gov/24066883
Autor:
Yuri L. Lyubchenko, Alexey V. Krasnoslobodtsev, Jie Peng, Jagadish Hindupur, Josephat M. Asiago, Jean-Christophe Rochet
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 5, p e38099 (2012)
PLoS ONE, Vol 7, Iss 5, p e38099 (2012)
Alpha-synuclein (α-Syn) is a 140 aa presynaptic protein which belongs to a group of natively unfolded proteins that are unstructured in aqueous solutions. The aggregation rate of α-Syn is accelerated in the presence of physiological levels of cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d33aca6c2a05c3566f6ef67c7d26b3d
http://europepmc.org/articles/PMC3360652
http://europepmc.org/articles/PMC3360652